Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52197-12-3, name is 5-Methylpyrazine-2,3-dicarbonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 5-Methylpyrazine-2,3-dicarbonitrile
Magnesium shavings (0.337 g, 13.88 mmol) and a small iodinecrystal were refluxed in n-butanol (20 mL) for 5 h. After the mixturewas cooled to roomtemperature, 5-methylpyrazine-2,3-dicarbonitrile(1 g, 6.94 mmol) was added to the reaction mixture and heated underreflux for 20 h. After this time, the reaction mixture was cooled toroom temperature, filtered off through Celite and the solvent wasremoved using a rotary evaporator. Purification of the product wasaccomplished by washing the crude product with acetonitrile, nhexane,ethyl acetate, acetonitrile, toluene, tetrahydrofuran, chloroform,dichloromethane, ethanol,methanol and acetone for 12 h in theSoxhlet apparatus. The dark blue product was dried under vacuum at50 C. The MgPz is soluble in DMFand DMSO. Yield: 0.26 mg (39.06%).Mp > 300C. FT-IR (ATR) nu/cm-1: 712, 747, 766, 948 (=C-H bend),1071,1093,1137 (C-C str.),1205,1277,1321,1376 (C-N str.), 1475, 1515(C-H bend.),1573,1594 (C=C str.),1633 (C=N str.), 2869, 2962 (>CH2str.), 3096 (-C=H str.). UVeVis (DMSO, 1 x 10-5 M): lambdamax(nm), (log epsilon):344 (4.69), 581 (4.23), 636 (4.86). 1H NMR(600 MHz, DMSO-d6, ppm):delta = 8.76-8.12 (m, 4H aromatic-CH), 2.41 (bs,12H, -CH3). MS (MALDI-TOF)m/z: Calculated 600.84, found 601.98 [MH]. Calculated forC28H16N16Mg: C, 55.97%; H, 2.68%; N, 37.30%; found C, 56.15%; H,2.92%; N, 36.96%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.