Category: 5049-61-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5049-61-6, name is Pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Pyrazin-2-amine

The mixture of aminopyrazine (3.0 g, 0.03316 mol) and 2-bromoethylpyruvate (4.77 mL, 0.0379 mol) in anhydrous ethanol (150 mL) was heated under continuous nitrogen flow at reflux for 6 hours. The reaction mixture was treated with charcoal (10 g), filtered through a CeliteNo. pad and concentrated under reduced pressure down to 25 mL. The solution was added dropwise to the saturated solution of sodium bicarbonate in water (300 mL) and the aqueous layer was extracted with DCM (3×200 mL). The combined organic extracts were dried with magnesium sulfate and concentrated. The residue was suspended in ether (40 mL) and the precipitate was collected by filtration and dried to yield imidazo[1,2-a]pyrazine-2- carboxylic acid ethyl ester (1.4 g, 0.0073 mol) as an off-white solid. m/z: (M + H)+ 192.

According to the analysis of related databases, 5049-61-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ABBOTT LABORATORIES; WO2005/110410; (2005); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 5049-61-6, name is Pyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5049-61-6, Product Details of 5049-61-6

Step 1 : 2-Amino-5-bromopyrazine: To a 0C cooled and stirred solution of 2-aminopyrazine (10 g, 105 mmol, 1.0 eq) in DCM (1000 mL) was added N-bromosuccinimide (16.8 g, 94.6 mmol, 0.9 eq) portion wise and the resulting solution was stirred at the same temperature for 30 min. The reaction mixture was filtered while keeping the filtrate at 0C and cold water (500 mL) was added to the filtrate. The layers were separated and the organic layer was washed with brine (200 mL), dried (Na2S04) and filtered. The filtrate was concentrated under vacuum. The crude product was purified by re-crystallization using DCM and hexane to afford 12 g of the desired product as a pale yellow solid. 1HNMR (400 MHz, CDC13) delta 8.06 (s, 1H), 7.75 (s, 1H), 4.72 (brs, 2H, D20 exchangeable); ESI-MS (m/z) 174, 176 [(MH)+ Br79′”].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LUPIN LIMITED; IRLAPATI, Nageswara, Rao; DESHMUKH, Gokul, Keruji; KARCHE, Vijay, Pandurang; JACHAK, Santosh, Madhukar; SINHA, Neelima; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2012/56478; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 5049-61-6, A common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-bromopvrazin-2-amine (M); To a solution of 2-aminopyrazine (1.00 g, 10.0 mmol) in chloroform (50 mL) and pyridine (0.8 mL, 10.0 mmol), solid pyridineNo.HBr3 (3.37 g, 10.0 mmol) was added in portions over 10 min. The reaction mixture was stirred at room temperature for 2 h. Saturated NaHCOs aqueous solution (25 mL) was added to this reaction mixture carefully (pH 7 to 8) and stirred for 10 min. Organic layer was separated, washed with water (15 mL x 3) (filtered if necessary), dried with Na2S04, filtered, and evaporated to dryness. The residue was purified using column chromatography (silica gel, 1:1:8 hexane/CH2CI2/EtOAc). The fractions containing product were evaporated to dryness under vacuum to yield compound M as a pale yellow solid (601 mg, 3.45 mmol, 35%). ¹H NMR (DMSO-d6, 300 MHz) No. 6.63 (bs, 2H), 7.67 (d, 1H, J, 1.4), 8.02 (d, 1 H, J, 1.4).

The synthetic route of 5049-61-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUGEN, INC.; WO2005/113548; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 5049-61-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5049-61-6 name is Pyrazin-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-amino pyrazine (20 g, 0.21 mmol) and DMSO (300 mL), was dissolved in water (10 mL), and the at ice bath N- iodosuccinimide ( 49.7 g, 0.22mmol) was added, after stirring for 30 minutes, stirred at room temperature for 12 hours. Ethyl acetate – extracted from the water, the organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane: ethyl acetate = 1: 1) as eluant to afford the title compound (18.5 g, 40%) as a yellow solid

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; Kowa Co., Ltd.; Watanabe, Toshiaki; Morimoto, Toshiharu; Ogiya, Tadaaki; Maejima, Takashi; (34 pag.)JP2015/54838; (2015); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5049-61-6, name is Pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Safety of Pyrazin-2-amine

A solution of Z-1 (10.0 g, 105 mmol) in DME (100 mL) is treated dropwise with the Z-2 (16.3 mL, 129 mmol) over lh at rt. After 3h, the mixture is cooled to 0C and filtered. The solid is washed with ether (50 mL) and dried under vacuum. The solid is heated in refluxing EtOH (100 mL) for 3h. The mixture is concentrated, the residue is dissolved in CHC13 (100 mL), and basified to pH 9 with sat. NaHC03 (100 mL). The suspension is filtered through a pad of Diatomaceous earth, which is washed with water (100 mL) and CHCI3 (3 x 100 mL). The phases are separated, and the aqueous layer extracted with CHCI3 (100 mL). The combined organic extracts are dried over MgS04, filtered and concentrated. The residue is crystallized from EtOH (100 mL) to give Z-3

According to the analysis of related databases, 5049-61-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRUNETTE, Steven, Richard; ABEYWARDANE, Asitha; BURKE, Michael, J.; KAPADIA, Suresh, R.; KIRRANE, Thomas, Martin, Jr.; NETHERTON, Matthew, Russell; RAZAVI, Hossein; RODRIGUEZ, Sonia; SAHA, Anjan; SIBLEY, Robert; SMITH KEENAN, Lana, Louise; TAKAHASHI, Hidenori; TURNER, Michael, Robert; WU, Jiang-Ping; YOUNG, Erick, Richard, Roush; ZHANG, Qiang; ZHANG, Qing; ZINDELL, Renee, M.; WO2013/134226; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5049-61-6, name is Pyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C4H5N3

Pyrazin-2-amine (2.85 g,30 mmol, 1 eq.) was dissolved in CH2Cl2 (150 mL) and cooled in icewaterbath. N-bromosuccinimide (NBS, 5.4 g, 30 mmol, 1 eq.) wasadded portionwise and stirred for 3 h at the same temperature. Themixture was filtered through a Celite, and the filtrate was washed withsaturated aqueous NaHCO3 solution (30 mL×3) and brine, dried overanhydrous Na2SO4 and concentrated under reduced pressure to obtain alight yellow solid 11a (2.7 g, 52%).1H NMR (300 MHz, DMSO-d6): delta8.01 (s, 1H), 7.66 (s, 1H), 6.62 (s, 2H). Compound 12a was synthesizedfrom 11a following the above diazotization and hydrolysis procedure.Yellow solid, yield: 57%. 1H NMR (300 MHz, DMSO-d6): delta 12.21 (br,1H), 8.07 (s, 1H), 7.90 (s, 1H). ESI–MS m/z: 173.0 [M – 1].

The synthetic route of 5049-61-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Guo, Shuang; Xu, Mingshuo; Guo, Qi; Zhu, Fuqiang; Jiang, Xiangrui; Xie, Yuanchao; Shen, Jingshan; Bioorganic and Medicinal Chemistry; vol. 27; 5; (2019); p. 748 – 759;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5049-61-6, name is Pyrazin-2-amine, A new synthetic method of this compound is introduced below., Quality Control of Pyrazin-2-amine

Under absence of light and at 0 C., N-bromosuccinimide (7.84 g, 44.05 mmol) was added to a solution of 2-aminopyrazine (4.19 g, 44.06 mmol) in dry dichloromethane (250 ml). The mixture was stirred for 20 h at 4 C. and then washed with four 40 ml portions of a saturated sodium carbonate solution in water. The organic layer was dried (MgSO4) and evaporated under reduced pressure, affording the title compound as 5.90 g of a light brown solid. Column chromatography, using silica and a dichloromethane/ethyl acetate (3/1) mixture as the eluent, yielded pure 2-bromo-5-aminopyrazine as 5.00 g (65%) of a light yellow solid. 1H-NMR (CDCl3, 400 Mhz): 8.09 (s, 1H, H-6), 7.77 (s, 1H, H-3), 4.65 (bs, 2H, NH) ppm. 13C-NMR (CDCl3, 100 Mhz): 153.5 (C-2), 144.3 (C-6), 131.9 (C-3), 126.8 (C-5) ppm.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 5049-61-6,Some common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0094] Pyrazin-2-amine (VIII) (1.91 g, 20.08 mmol) was dissolved in dimethylsulfoxide (DMSO) (40 mL) and distilled water (1 mL). To the resulting solution was slowly added dropwise N-Bromosuccinimide (NBS) (8.20 g, 46.07 mmol) at 0 C and the solution was stirred at room temperature for 16 hrs. Ice was added to the solution and the solution was stirred to give a yellow solid which was filtered to give the title compound (3.40 mg, 67 %). 1H NMR (400 MHz, CDCl3) delta 8.04 (s, 1H), 5.05 (br, 2H).

The synthetic route of 5049-61-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5049-61-6, name is Pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 5049-61-6

To a solution of 2-amino pyrazine (20 g, 210 mmol) in dimethoxy ethane (400 ml) was added ethyl bromopyruvate (32.8 ml) at 25 C. and the resulting reaction mixture was allowed to stir at the same temperature for 4 hrs. It was then cooled to 0 C. and stirred for 30 minutes. The separated solid was filtered and washed with ether. Solid residue was taken in ethanol (1000 ml) and refluxed for 4 hrs. Solvent was removed completely, residue taken in chloroform (1000 ml), saturated sodium bicarbonate solution (700 ml) was added to it and the mixture was allowed to stir for 45 minutes. The mixture was filtered through celite bed, washed several times with chloroform and filtrate was dried over sodium sulfate. Evaporation of the organic layer under reduced pressure gave the crude mass, which was purified by crystallization using ether-methanol mixture. Yield: 20%

According to the analysis of related databases, 5049-61-6, the application of this compound in the production field has become more and more popular.

Synthetic Route of 5049-61-6, A common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 250ml round bottom flask was charged with 2-aminopyrazine (1Og, O.lmol), N-chlorosuccinimide (14g, O.lmol) and dichloromethane (100ml) under nitrogen. The reaction mixture was refluxed for 5h, then allowed to cool to room temperature. The reaction mixture was filtered though a 1 cm thick celite pad, which was then thoroughly washed with dichloromethane. The EPO organic was concentrated in vacuo and the compound was purified by flash chromatography, using as eluent pentane/EtOAc 0% to 50%, to give the title compound (3g, 22%). IHNMR (CDCl3) 4.5-4.8 (2H, brs), 7.8 (IH, s), 8.0 (IH, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.