Category: 5049-61-6

Adding a certain compound to certain chemical reactions, such as: 5049-61-6, name is Pyrazin-2-amine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5049-61-6, 5049-61-6

Under absence of light and at 0 C., N-bromosuccinimide (15.68 g, 88.1 mmol) was added to a solution of 2-aminopyrazine (4.19 g, 44.06 mmol) in dry dichloromethane (250 ml). The mixture was stirred for 20 h at 4 C. and then washed with four 40 ml portions of a saturated sodium carbonate solution in water. The organic layer was dried (MgSO4) and evaporated under reduced pressure, affording the title compound as 12.8 g of a light brown solid. Column chromatography, using silica and a dichloromethane/ethyl acetate (3/1) mixture as the eluent, yielded pure 2-amino-3,5-dibromopyrazine as 5.00 g (65%) of a light yellow solid. 1H-NMR (CDCl3, 400 Mhz): 8.09 (s, I H), 4.95 (211, NH) ppm. 13C-NMR (CDCl3): 153.5 (C-2), 144.3, 131.9, 126.8 ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NDSU-Research Foundation; US2011/28721; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

A common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 5049-61-6.

To a solution of 2-amino pyrazine (2Og, 210 mmol) in dimethoxy ethane (400 ml) was added ethyl bromopyruvate (32.8 ml) at 25C and the resulting reaction mixture was allowed to stir at the same temperature for 4 hrs . It was then cooled to O0C and stirred for 30 minutes. The separated solid was filtered and washed with ether. Solid residue was taken in ethanol (1000ml) and refluxed for 4hrs. Solvent was removed completely, residue taken in chloroform (1000ml), saturated sodium bicarbonate solution (700 ml) was added to it and the mixture was allowed to stir for 45 minutes . The mixture was filtered through celite bed, washed several times with chloroform and filtrate was dried over sodium sulfate. Evaporation of the organic layer under reduced pressure gave the crude mass, which was purified by crystallization using ether-methanol mixture. Yield : 20%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazin-2-amine, its application will become more common.

Reference:
Patent; GRUeNENTHAL GMBH; WO2009/90055; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

A common compound: 5049-61-6, name is Pyrazin-2-amine, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 5049-61-6

Example 2 Synthesis of 3,5-dibromopyrazine-2-ylamine 11.2 ml of bromine in 38 ml of acetic acid were slowly added at 15 C., while stirring, to a solution of 2-aminopyrazine (9.5 g, 100 mmol) and sodium acetate trihydrate (32.6 g) in 150 ml of acetic acid. The addition required about 1-2 hours and it was carried out in the dark. The reaction mixture was stirred at room temperature overnight. The solution was concentrated in vacuo and the brown viscous residue was poured into ice water (150 ml) under stirring. Aqueous 20% sodium hydroxide was added in order to obtain a pH of 8 and extracted with ethyl acetate (4*75 ml). The combined organics were washed with water (2*50 ml) and brine (1*50 ml), dried and concentrated. The crude product was purified by column chromatography (2:1 hexanes and ethyl acetate) to provide the desired compound. HPLC: 8.7 min (98% pure) MS: MH+=251.8 C4H3Br2N3=250.8 g/mol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5049-61-6, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nuss, John M.; Ramurthy, Savithri; US2001/34051; (2001); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

5049-61-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5049-61-6 as follows.

3,5-Dibromo-2-aminopyrazine N-Bromosuccinimide (5.1 g, 28.7 mmol) was added slowly and portion wise to a mixture of aminopyrazine (1.3 g, 13.6 mmol) in dimethylsulfoxide (11 ml) and water (17 ml). During the addition of N-bromosuccinimide, the temperature of the reaction mixture was maintained below 15 C. After the addition, the reaction mixture was stirred for 16 h at RT. The reaction mixture was poured into ice water and extracted with ethyl acetate. The organic layer was washed with 10 % Na2C03 solution followed by washing with water and brine. The organic layer was collected, dried over sodium sulfate and concentrated in vacuo to obtain crude product. The product was purified using column chromatography. Yield: 1.51 g 1H NMR (CDC13): 5.04 (2H, s), 8.03 (1H, s)

According to the analysis of related databases, 5049-61-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MEDEIA THERAPEUTICS LTD; GOLDSTEINS, Gundars; KOISTINAHO, Jari; KOISTINAHO, Milla; RATILAINEN, Jari; PYSTYNEN, Jarmo; WO2014/68171; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5049-61-6, name is Pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., 5049-61-6

To a stirred solution of pyrazin-2-amine (2.00 g, 21 .0 mmol) in CHCI3 (25 mL) was added NCS (3.65 g, 27.3 mmol) portionwise and the reaction mixture was stirred at room temperature for 6h. Progress of reaction was monitored by TLC. After completion, the reaction mixture was poured in to ice cold H20 (20 mL) and extracted with EtOAc (2 c 40 mL). The organic layer was separated, washed with brine (25 mL), dried over anhydrous Na2S04 and concentrated under vacuum. The crude obtained was purified by combi flash chromatography (20% EtOAc in hexane) to afford 3,5-dichloropyrazin-2-amine X-10a (1 .50 g) as an off-white solid. Yield: 37%. (0851) 1H NMR (400 MHz, DMSO-cfe) d 7.02 (brs, 2H), 8.06 (s, 1 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; UCB PHARMA GMBH; PEGURIER, Cecile; PROVINS, Laurent; CARDENAS, Alvaro; LEDECQ, Marie; MUELLER, Christa E.; HOCKEMEYER, Joerg; EL-TAYEB, Ali; BOSHTA, Nader; RASHED, Mahmoud; (165 pag.)WO2019/243303; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding some certain compound to certain chemical reactions, such as: 5049-61-6, name is Pyrazin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5049-61-6. 5049-61-6

C1: According to the standard of adding 1 g of 2-cyanopyrazine to 20 ml of solvent, 100 ml of a sodium hypochlorite solution and 100 ml of a mixed solution of sodium hydroxide and potassium hydroxide are sequentially added to 10 g of 2-cyanopyrazine.The pH of the mixed solution of sodium hydroxide and potassium hydroxide is 8,Then stirring at 40 C for 2 hours, followed by hydrolysis, rearrangement to obtain 2-aminopyrazine; C2: the 2-aminopyrazine obtained in the step C1 is added to the bromine to carry out a bromination reaction for 0.5 hour to obtain 2-amino-3,5-dibromopyrazine; C3 The 2-amino-3,5-dibromopyrazine obtained in the step C2 is subjected to a substitution reaction with morpholine at 40 C for 0.5 hour in a molar ratio of 1:1 to obtain 2-amino-5-bromo-3- Morpholinylpyrazine solution; C4: 2-amino-5-bromo-3-morpholinylpyrazine was dissolved and distilled to remove an organic solvent, followed by washing with water for 2 hours to obtain crude 2-amino-5-bromo-3-morpholinylpyrazine; C5: The crude 2-amino-5-bromo-3-morpholinylpyrazine was repeatedly subjected to rectification three times to obtain a finished product.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Pyrazin-2-amine.

Reference:
Patent; Zaozhuang Jiu Xing Biological Technology Co., Ltd.; Sun Yan; (5 pag.)CN108570011; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

5049-61-6, Adding a certain compound to certain chemical reactions, such as: 5049-61-6, name is Pyrazin-2-amine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5049-61-6.

To a stirred solution of aminopyrazine (8.21 g, 86.4 mmol) in anhydrous methylene chloride (215 mL) cooled to 00C was added N-bromosuccinimide (32.3 g, 181 mmol) in portions over a six hour period, during which time the temperature of the reaction was kept below 00C. The resulting mixture was stored at 4C overnight, after which it was stirred vigorously and quenched with H2O (100 mL). The organic layer was separated, after which it was washed with saturated aqueous NuaHCC>3, washed with brine, dried over MgSO4, filtered, and evaporated in vacuo to yield a residue that was triturated with 20% EtOAc in hexanes to yield the title compound (10.3 g, 47%) as a yellow/brown powder. 1H NMR (CDCl3, 300MHz) delta 8.02 (s, IH), 5.05 (bs, 2H); HPLC retention time: 1.99 minutes; MS ESI (m/z): 252.0/254.0/256.2 (M+ 1)+, calc. 251.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITY OF ROCHESTER; GELBARD, Harris, A.; DEWHURST, Stephen; GOODFELLOW, Val, S.; WIEMANN, Torsten; WO2010/68483; (2010); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

5049-61-6, A common compound: 5049-61-6, name is Pyrazin-2-amine, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Example 1 1-(5-{[3-(Cyclopropylmethyl)-2,3,4,5-tetrahydro-1 H-3-benzazepin- 7 -yl]oxy}-2- pyrazinyl)-2-pyrrolidinone (E1) Step 1: 5-Chloro-2-pyrazinamine; Aminopyrazine (10g, 10.5mmole) was dissolved in dry dimethylformamide (60ml) and was treated with N-chlorosuccinimide (15.36g, 11.5mmole) under argon at 0C. The mixture was stirred for 30 minutes and then allowed to warm to room temperature. The mixture was poured onto water and extracted with diethyl ether (x 5). The diethyl ether layers were combined and evaporated in vacuo. The resulting residue was purified by column chromatography (1: 9 ethyl acetate: pentane) to afford the title compound (1.40g). ?H NMR (CDCI3) 8.02 (1H, s), 7.76 (1H, s), 4.61 (2H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2005/97778; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

5049-61-6, Adding a certain compound to certain chemical reactions, such as: 5049-61-6, name is Pyrazin-2-amine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5049-61-6.

EXAMPLE 1A 5-bromo-2-pyrazinamine A 0 C. solution of 2-aminopyrazine (15.0 g, 157 mmol) in dichloromethane (900 mL) was treated with N-bromosuccinimide (28.2 g, 159 mmol), stirred for 3.5 hours, and filtered through diatomaceous earth (Celite). The filtrate was treated with silica gel (300 g) and concentrated. The concentrate was purified by flash column chromatography with 30% ethyl acetate/hexanes to provide 22.09 g (81.5%) of the desired product. MS (APCI(+)) m/z 174 (M+H)+; 1H NMR (300 MHz, CDCl3) delta 8.09 (d, J=1.4 Hz, 1H), 7.77 (d, J=1.7 Hz, 1H), 4.30-4.78 (br s, 2H).

According to the analysis of related databases, 5049-61-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Li, Goaquan; Li, Qun; Li, Tongmei; Lin, Nan-Horng; Mantei, Robert A.; Sham, Hing L.; Wang, Gary T.; US2004/34038; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The chemical industry reduces the impact on the environment during synthesis 5049-61-6, name is Pyrazin-2-amine, I believe this compound will play a more active role in future production and life. 5049-61-6

2-Aminopyrazine (Aldrich, 20 g, 0.21 mol) was dissolved in 600 mL of CH2Cl2 and then cooled to 0 C. in an ice bath. To the resulting slurry was added N-Bromosuccinimide (Aldrich, 37.6 g, 0.211 mol) portion-wise over approximately 10 min. The slurry was allowed to mix in the ice bath for 1.5 hr. The slurry was then filtered through a bed of Celite. The bed of Celtite was washed with ~150 mL CH2Cl2. The filtrate was then concentrated in vacuo to solids. The resulting solids were purified by chromatography (silica, ethyl acetate/hexanes), producing 19.4 g (53%) of product. 1H NMR confirmed the structure of the desired product.

The chemical industry reduces the impact on the environment during synthesis 5049-61-6. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; Brown, David L.; Carroll, Jeffery N.; Chen, Yiyuan; Fobian, Yvette M.; Freskos, John N.; Gasiecki, Alan F.; Grapperhaus, Margaret L.; Heintz, Robert M.; Hockerman, Susan L.; Kassab, Darren J.; Khanna, Ish K.; Kolodziej, Stephen A.; Massa, Mark A.; McDonald, Joseph J.; Mischke, Brent V.; Mischke, Deborah A.; Mullins, Patrick B.; Nagy, Mark A.; Norton, Monica B.; Rico, Joseph G.; Schmidt, Michelle A.; Stehle, Nathan W.; Talley, John J.; Vernier, William F.; Villamil, Clara I.; Wang, Lijuan J.; Wynn, Thomas A.; US2005/9838; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem