These common heterocyclic compound, 4925-61-5, name is 6-Chloropyrazin-2-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 4925-61-5
Weigh 2.38g of compound 6, 3.90g of compound 5, and add 4.0g of potassium carbonate to a 100mL round bottom flask. 50 mL of anhydrous acetonitrile was added and reacted at 50C for 5 hours. The reaction solution was cooled to room temperature, filtered, and the filtrate was concentrated on silica gel column chromatography (ethyl acetate/petroleum ether=1/10). 3.44 g of white solid compound 7 was obtained with a yield of 69%.
The synthetic route of 6-Chloropyrazin-2-ol has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Leng Ying; Chen Wuhong; Ning Mengmeng; Wang Lang; Zeng Limin; (27 pag.)CN107556252; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem