Category: 486460-21-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. 486460-21-3

333 mg (1 mmol) of 3S-t-butoxycarbonylamino-4-(t-butyl-dimethyl-silanyloxy)- butanoic acid which was obtained from step (1) was added 192 mg (1 mmol) of 3-trifluoromethyl-5,6-dihydro-8H-[l,2,4]triazolo[4,3-a]pyrazine, and the resulting mixture was dissolved in dichloromethane. The reaction solution was cooled to 0C, and 162 mg (1.2 mmol) of HOBT was added, followed by stirring for 10 minutes and then addition of 288 mg (1.5 mmol) of EDC. After removal of an icebath, the reaction solution was stirred for abour 13 hours, and then the residue, which was obtained by concentration was purified by column chromatography (1:1 hexane: ethyl acetate) to give 0.27 g of the title compound in yield of 53%.[582] 1H NMR (CDCl3) delta 5.1-5.3 (IH, m), 4.9-5.1(2H, m), 3.9-4.3 (4H, m), 3.7-3.8 (2H, m), 2.6-2.9 (2H, m), 1.40(9H, s), 0.87 (9H, s), 0.03 (6H, s)[583] Mass (m/e) 508 (M+l)

The synthetic route of 486460-21-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG LIFE SCIENCES, LTD.; WO2006/104356; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 486460-21-3, 486460-21-3

Step 1: Preparation of 1-[4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-phenyl]-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl esterTo a solution of 1-(4-bromo-phenyl)-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester (Intermediate I, 400 mg, 1.18 mmol) in anhydrous toluene (5 mL) were added Pd2(dba)3 (5.4 mg, 0.006 mmol), BINAP (11.0 mg, 0.018 mmol), sodium tert-butoxide (227 mg, 2.34 mmol) and 3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (prepared by the procedure as described in reference J. Med. Chem., 2005, 48, 141-151) (340 mg, 1.77 mmol) at r.t. and reaction mixture was refluxed for 6 h. Reaction mixture was then concentrated and the crude product was purified by column chromatography (silica gel, 6:4 EtOAc:Pet. ether) to afford the title compound as white solid (330 mg, 62%).ESIMS (m/z): 472.9 (M+23), 451.9 (M+2), 450.8 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PANACEA BIOTEC LTD.; US2012/165320; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

486460-21-3, Adding a certain compound to certain chemical reactions, such as: 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 486460-21-3.

In a 50 ml round bottom flask,0.17 g (0.90 mmol)(Trifluoromethyl) -5,6,7,8-tetrahydro [1,2,4]Triazolo [4,3-alpha] piperazine,2.0 g of a formaldehyde aqueous solution having a mass fraction of 37% and 15 ml of absolute ethanol, stirred at room temperature for 15 minutes,Followed by the addition of 4 – ((R 2 -methylene) amino) -5-R1-2,4-dihydro-3H-1,2,4-triazole-After stirring at room temperature for 1 h,Filter,Washed with absolute ethanol,To obtain the desired solid product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nankai University; Wang, Baolei; Li, Zhengming; Zhang, Yan; (13 pag.)CN106749262; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem