Category: 486460-20-2

Electric Literature of 486460-20-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 486460-20-2 name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 3-(trifluoromethyl)-[l ,2,4]triazolo[4,3-a]pyrazine ( 1 .60 g) in metanol(20 mL) was added a catalytic amount of Pd/C. The suspension was stirred under H2 for 5 h, and then filtered. The filtrate was concentrated in vacuo to give a residue, which was used for next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, and friends who are interested can also refer to it.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu; WO2013/71697; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 486460-20-2 as follows. Safety of 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine

The compound 4a (1g) (5.33 mmol) was hydrogenated at atmospheric pressure in ethanol (10 mL) using 10% Pd/C as catalyst (500 mg) at ambient temperature for 10 hour. The reaction mixture was filtered over celite and the celite bed was washed with 5 mL of ethanol and the filtrate was concentrated under reduced pressure. The obtained crude mass was passed through a small plug of silica using (5 to 8% of methanol in dichloromethane to give 0.9 g (87%) of the product as oil.

According to the analysis of related databases, 486460-20-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Nitlikar, Lakshmikant H.; Darandale, Sunil N.; Shinde, Devanand B.; Letters in Organic Chemistry; vol. 10; 5; (2013); p. 348 – 352;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine

Using Procedure G-3 (Table 5) with compound 478 the title compound 479 (crude) was obtained (130 mg, 89%) as a brown oil. MS (m/z): 193.1 (M+H)

The synthetic route of 486460-20-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Forum Pharmaceuticals, Inc.; Rogers, Kathryn; Patzke, Holger; (315 pag.)US2017/749; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 486460-20-2

A solution of 5.0 g (26.6 mmol) of 3- (trifluoromethyl) -1,2,4-triazolo [4,3-a] pyrazine 3.0 g and a mass fraction of5% by weight of palladium on charcoal was charged into a 100 ml three-necked flask containing 50 ml of absolute ethanol and hydrogen gas was bubbled at 30 C under magnetic stirring,Atmospheric hydrogenation 20H, after the reaction is filtered, the filtrate by activated carbon decolorization, the column chromatography, yellow-brown liquid 3.5G, the yield 68.5%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nankai University; Wang, Baolei; Li, Zhengming; Zhang, Yan; (13 pag.)CN106749262; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 486460-20-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Using Procedure G-3 (Table 5) with compound 478 the title compound 479 (crude) was obtained (130 mg, 89%) as a brown oil. MS (m/z): 193.1 (M+H)

The synthetic route of 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Forum Pharmaceuticals, Inc.; Rogers, Kathryn; Patzke, Holger; (315 pag.)US2017/749; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 486460-20-2, Recommanded Product: 486460-20-2

A mixture of compound 10 (12.0 g, 0.064 mol) and the catalyst,Pd/C (10% w/w, 120.0 mg) in methanol (MeOH)(120 mL) was charged into an autoclave (500 mL) at ambienttemperature. The reaction mass was agitated for 24 h bymaintaining 3.5-4.5 Kg/cm2 hydrogen pressure at 40-45 C.The completion of reaction was judged by TLC. The reactionmass was concentrated under reduced pressure afterremove the Pd/C catalyst by passing through celite undernitrogen atmosphere. The residue was dissolved in IPA(24.0 mL) and then IPA.HCl (24.0 mL) was added slowly at 0-5 C. The precipitated solid was separated by filtration,after one hour agitation of the reaction mass, to obtain 3-trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo-[4,3-a]pyrazinehydrochloride (11) as a white crystalline solid (12.1 g, 82.9%).m.p.: 237-249 C (Lit. 236-246 C reported in chemical book).1H NMR (400MHz; DMSO-d6), d, ppm (J, Hz): 3.65 (2H, t,J5.6, Piperazine); 4.46 (2H, t, J5.6, Piperazine); 4.61(2H, s, Piperazine); 10.58 (2H, br, NH2). 13C NMR(100MHz; DMSO-d6) d, ppm (J, Hz): 39.09 (-CH2-CH2-),40.14 (-CH2-CH2-), 40.90 (-CH2-), 117.17 (d, J268.4, CF3),142.29 (C triazole), 148.73 (C triazole). LC-MS m/z (rel, %):193.08 (M+H)+ (100).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mannam, Madhava Rao; Devineni, Subba Rao; Pavuluri, Chandra Mouli; Chamarthi, Naga Raju; Kottapalli, Raja Sekhara P.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 194; 9; (2019); p. 922 – 932;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 486460-20-2, A common heterocyclic compound, 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, molecular formula is C6H3F3N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 5.0 g (26.6 mmol) of 3- (trifluoromethyl) -1,2,4-triazolo [4,3-a] pyrazine 3.0 g and a mass fraction of5% by weight of palladium on charcoal was charged into a 100 ml three-necked flask containing 50 ml of absolute ethanol and hydrogen gas was bubbled at 30 C under magnetic stirring,Atmospheric hydrogenation 20H, after the reaction is filtered, the filtrate by activated carbon decolorization, the column chromatography, yellow-brown liquid 3.5G, the yield 68.5%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nankai University; Wang, Baolei; Li, Zhengming; Zhang, Yan; (13 pag.)CN106749262; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 486460-20-2, A common heterocyclic compound, 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, molecular formula is C6H3F3N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-(trifluoromethyl)-[l ,2,4]triazolo[4,3-a]pyrazine ( 1 .60 g) in metanol(20 mL) was added a catalytic amount of Pd/C. The suspension was stirred under H2 for 5 h, and then filtered. The filtrate was concentrated in vacuo to give a residue, which was used for next step without further purification.

The synthetic route of 486460-20-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu; WO2013/71697; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 486460-20-2, category: Pyrazines

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine (540 mg, 2.87 mmol, from Step A) was hydrogenated under atmospheric hydrogen with 10% Pd/C (200 mg) as a catalyst in ethanol (10 mL) at ambient temperature for 18 h. Filtration through Celite followed by concentration gave a dark colored oil. Dichloromethane was added to the above oil and the insoluble black precipitate was filtered off. Concentration of the filtrate gave the title compound as an oil (495 mg). 1H NMR (500 MHz, CDCl3) delta 2.21 (br, 1H), 3.29 (t, 2H, J=5.5 Hz), 4.09 (t, 2H, J=5.5 Hz), 4.24 (s, 2H). LC/MS (M+1) 193

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, and friends who are interested can also refer to it.

Reference:
Patent; Merck Sharp & Dohme Corp.; Edmondson, Scott D.; Fisher, Michael H.; Kim, Dooseop; Maccoss, Malcolm; Parmee, Emma R.; Weber, Ann E.; Xu, Jinyou; US2015/359793; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H3F3N4

A mixture of 250 mg (1.33 mmol) of 3-(trifluoromethyl)[l,2,4]triazolo[4,3-a]pyrazine(Intermediate 6, Step A), 0.479 mL (4.66 mmol) of 30% hydrogen peroxide aqueous solution, and 2 mLof glacial acetic acid was stirred at 95 C. After 8 h, the solution was cooled and concentrated. Theresidue was partitioned between dichloromethane and saturated sodium bicarbonate aqueous solution.Thin-layer chromatography on silica gel (90:10:1 dichloromethane:methanol:concentrated ammoniumhydroxide solution) revealed that the product was in the aqueous phase. Therefore, the aqueous solutionwas concentrated to dryness, and the residue was purified by preparative HPLC (C18 reverse phasecolumn, 0-50% acetonitrile in water containing 0.05% trifluoroacetic acid) to provide the title compoundas a white solid. LC-MS 205 (M+l).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 486460-20-2.

Reference:
Patent; MERCK & CO., INC.; WO2006/23750; (2006); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem