Category: 486424-37-7

486424-37-7, A common compound: 486424-37-7, name is 3-Amino-6-bromopyrazine-2-carboxylic acid, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

1- (3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE hydrochloride (0.68 g, 3.5 mmol) was added in one portion to a stirred suspension of 2-MORPHOLIN-4-YLETHANAMINE (0.422 g, 3.2 mmol), 3-amino-6-bromopyrazine-2-carboxylic acid (0.64 g, 3.0 mmol; described in: Ellingson, R. C.; Henry, R. L. J. Am. Chem. Soc. 1949,2798-2800), and 1- hydroxybenzotriazole hydrate (0.48 g, 3.5 mmol) in acetonitrile (25 mL) at 0 C. The cooling bath was removed and stirring was continued at room temperature for 7 h. The solid was filtered off, washed with acetonitrile and purified by column chromatography on silica using methylene CHLORIDE/METHANOL/TRIETHYL amine, (95: 5: 0.1), to give 0.68 g (69% yield) of the title compound : 1H NMR (DMSO-d6, 400 MHz) 8 8.53 (m, 1 H), 8.34 (s, 1 H), 8.68 (br s, 2 H), 3.57 (t, J = 5 Hz, 4 H), 3.37 (q, J = 7 Hz, 2 H), 2.47 (q, J = 7 HZ, 2 I-, 2.40 (m, 4 H); MS (ES) M/Z 330 and 332 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-6-bromopyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; WO2004/55009; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The chemical industry reduces the impact on the environment during synthesis 486424-37-7, name is 3-Amino-6-bromopyrazine-2-carboxylic acid, I believe this compound will play a more active role in future production and life. 486424-37-7

(Step 2) (1084) To a solution of 3-amino-6-bromopyrazine-2-carboxylic acid (10 g, 45.87 mmol) in DMF (50 mL) were added HATU (26.16 g, 68.8 mmol) and DIEA (80.1 mL, 458.7 mmol) at room temperature. Ethylamine (2 mol/L, THF solution, 114.65 mL, 229.3 mmol) was added thereto at room temperature, and the mixture was stirred at room temperature for 20 hr. The reaction mixture was concentrated under reduced pressure, to the residue was added ethyl acetate, and the solution was washed with water. The aqueous layer was extracted with ethyl acetate (x3). The organic layer was washed with water and saturated brine, and dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent; 15% ethyl acetate/hexane) to give 3-amino-6-bromopyrazine-2-carboxylic acid ethylamide (6.60 g, 59%) as a pale yellow solid. 1H-NMR(400MHz,DMSO-d6) :delta1.10(t,3H,J=7.20Hz),3.24-3.30(m,2H),7.69(brs,2H),8.33(s,1H),8.60(t-like,1H,J=5.44Hz).

The chemical industry reduces the impact on the environment during synthesis 486424-37-7. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Takeda Pharmaceutical Company Limited; YAMAMOTO, Satoshi; SHIRAI, Junya; FUKASE, Yoshiyuki; SATO, Ayumu; KOUNO, Mitsunori; TOMATA, Yoshihide; OCHIDA, Atsuko; YONEMORI, Kazuko; ODA, Tsuneo; IMADA, Takashi; YUKAWA, Tomoya; (238 pag.)EP2975031; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem