Category: 4858-85-9

Application of 4858-85-9, These common heterocyclic compound, 4858-85-9, name is 2,3-Dichloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 2,3-dichloropyrazine (5) (2000mg, 13.42mmol) LHMDS (6.0ml, 30.87mmol) (1M in THF) under nitrogen condition was added dropwise a soution of ethyl acetate (1.44ml, 14.76mmol) in toluene (20ml) .The reaction mixture was stirred at room temperature for 24 h. Then, the reaction mixture was diluted with Et2O and was quenched with saturated aq. NH4Cl. The two layers were separated and the aq. one was further extracted with Et2O. The combined organic layers were washed with brine, dried over MgSO4 and concentrated in vacuo. The crude was then purified by flash column chromatography (EtOAc/Heptane, 15:85). The desired fractions were concentrated to dryness in vacuo to afford 3 (1850mg, 8.76mmol, 65%) as a pale yellow oil.

Statistics shows that 2,3-Dichloropyrazine is playing an increasingly important role. we look forward to future research findings about 4858-85-9.

Reference:
Article; Luise, Nicola; Wyatt, Paul G.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 248 – 251;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 4858-85-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4858-85-9, name is 2,3-Dichloropyrazine, This compound has unique chemical properties. The synthetic route is as follows.

A 100 mL round bottom flask was charged with 2,3-dichloropyrazine (10 g, 67.6 mmol), hydrazine hydrate (6.76 g, 135 mmol) and ethanol (40 mL). The resulting mixture was stirred at reflux for 3 h. Reaction progress was monitored by TLC (EtO Ac/petroleum ether = 2:1). Work-up: the reaction mixture was cooled to room temperature. The solid was collected by filtration, washed with water (30 mL x 2) and dried, to afford 8.4 g (87%) of the product as a yellow solid.

The chemical industry reduces the impact on the environment during synthesis 2,3-Dichloropyrazine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; NOBLE, Stewart, A.; WO2011/112766; (2011); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4858-85-9, name is 2,3-Dichloropyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C4H2Cl2N2

2,3-Dichloropyrazine (5.0 g, 33.6 mmol) and 28% ammonia water (20 mL) were placed in a tube, sealed and stirred at 100 C. for 18 hours. The reaction solution was diluted with water, the resultant solid substance was obtained by filtration to obtain 3-chloropyrazine-2-amine (3.46 g, 100%) as a white solid substance.MS (ESI) m/z=130 (M+H)+.

The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Oncotherapy Science, Inc.; US2012/59162; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 4858-85-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4858-85-9, name is 2,3-Dichloropyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Dissolve 2,3-dichloropyrazine (20 g, 0.134 mol) in ethanol, and add hydrazine hydrate (21 g, 0.42 mol) in small portions for multiple times and reflux at 85 C.The reaction was detected by TLC until the reaction was complete. After the reaction solution was cooled, it was added to ice water and stirred.The precipitated solid was suction-filtered and the filter cake was dried to obtain 16.8 g of a yellow-yellow powder with a yield of 84.1%.

The synthetic route of 2,3-Dichloropyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangxi Science and Technology Normal University; Zhu Wufu; Zheng Pengwu; Xu Shan; Liu Xiaobo; Zhang Qian; Zhou Lingjia; Han Haoyun; Yu Li; Zhou Hualan; Qiu Yufeng; (25 pag.)CN110467616; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4858-85-9, name is 2,3-Dichloropyrazine, This compound has unique chemical properties. The synthetic route is as follows., Formula: C4H2Cl2N2

2,3-Dichloropyrazine (III-9) (500 mg, 3.36 mmol) and 4-chlorophenol (II-17) (431 mg, 3.36 mmol) were dissolvedin DMF (10 mL), potassium carbonate (557 mg, 4.03 mmol) was added and the mixture was stirred at 90C for 15 hr.The reaction mixture was cooled, water was added, and the mixture was extracted with ethyl acetate. The organic layerwas washed successively with water and saturated brine, and the solvent was evaporated under reduced pressure. Theresidue was purified by silica gel column chromatography (n-hexane:ethyl acetate = 100:0 ? 85:15) to give compound(IV-102) (yield 809 mg, quantitative) as a white solid

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4858-85-9.

Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; WATANABE, Atsushi; SATO, Yuuki; OGURA, Keiji; TATSUMI, Yoshiyuki; (331 pag.)EP3351533; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4858-85-9, name is 2,3-Dichloropyrazine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2,3-Dichloropyrazine

A thick-walled reaction vessel (250 mL) charged with 2, 3-dichloropyrazine (14.9 g, 95 mmol) and 28-30% ammonium hydroxide (75 mL) was sealed in vacuo, submitted to a freeze-pump- thaw cycle and then heated with stirring to 135 C for 15 h. Upon cooling of the reaction mixture, needles were observed to form from the reaction mixture. The supernatant was decanted off and the residual solid was solubilized in hot methanol. The methanol solution was concentrated in vacuo and the resultant crude material (10. 8 g) was recrystallized from methanol (150 mL) to yield 8.26 g of the title compound (67% yield). mp 167-168 C ; Rf 0.5 (EtOAc-hexanes, 1 : 1, v/v, +0.5% v/v iPrNH2) ;’H NMR (DMSO-d6) 8 8.9 (s, 1H), 8. 7 (s, 1H), 5.0 (br s, 2H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4858-85-9.

Reference:
Patent; CARDIOME PHARMA CORPORATION; WO2005/34837; (2005); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 4858-85-9, name is 2,3-Dichloropyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4858-85-9, name: 2,3-Dichloropyrazine

To 2,3-Dichloro-pyrazine (18 g, 120.82 mmol), ammonium hydroxide (50 ml, 1280 mmol) is added and the reaction mixture is microwaved at 140 C. for 25 minutes. The reaction mixture is filtered and washed with water to yield 3-Chloro-pyrazin-2-ylamine.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BRUCE, Ian; BUDD, Emma; EDWARDS, Lee; HOWSHAM, Catherine; US2009/239847; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

4858-85-9, name is 2,3-Dichloropyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2,3-Dichloropyrazine

2,3-Dichloropyrazine (2 mL, 13 mmol) was dissolved in 95% ethanol (4 mL) and to this was added, dropwise and with stirring, hydrazine anhydrous (2 mL, 67 mmol). During the addition of the hydrazine the solution became warm and yellowish. Following cooling of this mixture in an ice bath, the resulting material was isolated by filtration, washed with cold aqueous 95% ethanol to riled 1-(3-chloropyrazin-2-yl)hydrazine (1.42 g, 73% yield) as white crystals. No further purification was done. MS m/z: 145.0 (M+1).

The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Amgen Inc.; US2010/120774; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 4858-85-9, name is 2,3-Dichloropyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4858-85-9, HPLC of Formula: C4H2Cl2N2

Similar to as described in General Procedure A, 2,3-dichloropyrazine was reacted with2-methoxyethan-1-amine to give the title compound (4 g, 79%) as a white solid. LC-MS (ES, mlz):189 [M+H]+. To a solution of nitrogen-containing nucleophile (1 eq.) and cesium carbonate (3.0 eq.) in N,N-dimethylformamide (2 mL/mmol) was added 2-haloheterocycle (1.1 eq.). The reaction washeated to 100 C and stirred at this temperature for 2 hours. The reaction was then cooled to room temperature and acidified to pH = 1 with 10 % aqueous HCl solution if product contains a carboxylic acid, or diluted with water if neutral. The solution was extracted with twice with dichloromethane. The organic layers were combined, dried with sodium sulfate and concentrated under vacuum. The crude material was either used directly in subsequent reactions or purified byflash chromatography.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; LIN, Xingyu; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25026; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

4858-85-9, name is 2,3-Dichloropyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2,3-Dichloropyrazine

Under a nitrogen atmosphere, in 25 ml substrate is added into the test tube reactor 3dam (0.2mmol, 29.6 mg), 1-chlorobutane (3.0mmol, 276.0 mg), PdCl2(dppf) (0.02mmol, 14.6 mg), DPPF (0.01mmol, 5.6 mg), Cs2CO3(0.3mmol, 195.0 mg), Na2S2O35H2O (0.5mmol, 248.0 mg), DMSO (4.0 ml) and glycol (0.1 ml). Heating the reaction system to 120 C for reaction. TLC detection after the reaction is ended, the system is cooled to room temperature. Hydrosolvent quenching reaction with saturated ammonium chloride, extracted with ethyl acetate (3*10 ml), column chromatography purification to obtain the product 3da (88%).

The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; East China Normal University; JIANG, XUE FENG; QIAO, ZONG JUN; (33 pag.)CN103848767; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem