Category: 4858-85-9

Adding a certain compound to certain chemical reactions, such as: 4858-85-9, name is 2,3-Dichloropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4858-85-9, Recommanded Product: 4858-85-9

A mixture 2,3-dichloro-pyrazine (5.0 g, 34 mmol), 1-isopropylpiperazine (6.5 g, 51 mmol) and potassium carbonate (7.0 g, 51 mmol) in acetonitrile (100 mL) was stirred at ambient temperature for 2 h. Addition of hexane, followed by filtration and concentration of the filtrate gave 9.5 g of crude material as an orange liquid. Purification by filtration through silica using heptane/EtOAc (3: 1), followed by EtOAc/acetone (1: 1), provided 6.5 g (79%) of the title compound as a yellow oil which solidified upon cooling. HPLC purity: 98%. MS m/z 241 (M+H) +. HRMS m/z calcd for C11H17ClN4 (M) + 240.1142, found 240.1138.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Dichloropyrazine, and friends who are interested can also refer to it.

Reference:
Patent; BIOVITRUM AB; WO2004/9586; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 4858-85-9, A common heterocyclic compound, 4858-85-9, name is 2,3-Dichloropyrazine, molecular formula is C4H2Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 100 mL three-necked flask, under N2 protection,Add magnesium chips (0.729g, 30mmol),Add 1 iodine (initiator),Add 10 mL of dry THF to immerse the magnesium chips,Start stirring,Add 2,3-dichloropyrazine (0.148 g, 1 mmol),Heating causes the reaction,THF reflux,The color of the iodine particles fades,Magnesium turnings indicate brightening,Lead to success.Stop heating,A solution of 2,3-dichloropyrazine in THF (4.291 g, 29 mmol, dissolved in 20 mL of dry THF) was slowly added dropwise.After the drop is over,Heated back to 65 degrees CelsiusFlow 1h.Get a new format reagent,The concentration is about 1 mol/L.At 100mLIn an eggplant-shaped bottle,JoinTetrabutylammonium chloride (0.278 g, 1 mmol),Under N2 protection,Slowly add the previously prepared format reagent (15mL, 15mmol).Stir at room temperature for 10 min,Then add diethylene glycol dimethyl ether (2.012g,15mmol),After stirring for 30 min at room temperature,Cool down to 0 to 5 degrees Celsius,A solution of 4-methylimino-N-2-pyridine-benzamide in THF (2.251 g, 10 mmol, 1.0 M in THF) was slowly added.After the addition was completed, the reaction solution was gradually warmed to room temperature for 2 h.After completion of the reaction, the reaction was quenched with 5 mL of aqueous hydrogen chloride (10%).Add 150 mL of a saturated aqueous solution of sodium bicarbonate,Extract twice with 100 mL of ethyl acetate.The organic layers were combined and washed with a saturated aqueous solution of sodium chloride.Dry over anhydrous sodium sulfate for 1 h,Dry under reduced pressure to obtain a crude product.Column chromatography with ethyl acetate/petroleum ether (1:2) gave 4-[amino-(3-chloro-2-pyridin2.82 g of pyrazinylmethyl]-N-(2-pyridyl)benzamide,The yield was 85% and the purity was 98%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Anqing Qichuang Pharmaceutical Co., Ltd.; Wu Xueping; Chu Yijie; Chen Yao; Wang Min; (10 pag.)CN109020977; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 4858-85-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4858-85-9, name is 2,3-Dichloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

2,3-Dichloropyrazine 5 (5.0 g, 33.6 mmol) in 28% aqueousammonia solution (20 mL) in a reactor Parrwas stirred at 100 C for17 h. After cooling, the resulting mixture was filtered, the solid waswashed with water and dried in vacuo to afford compound 6 (3.0 g,70%) as a white powder. Rf 0.37 (cyHex/EtOAc 1:1); Mp: 170 C (lit.[43]: 169.4e170.1 C); 1H NMR (400 MHz, DMSO-d6): d 6.83 (bs, 2H,NH2), 7.60 (d,1H, J 2.4 Hz, H5), 7.98 (d, 1H, J 2.4 Hz, H6); 13C NMR(100 MHz, DMSO-d6): d 130.6 (CH), 132.6 (C), 141.4 (CH), 152.7 (C);MS (ESI) m/z (%): 129.8 (100) [MH], 131.8 (40). [MH2].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dichloropyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Marchand, Pascal; Bazin, Marc-Antoine; Pagniez, Fabrice; Riviere, Guillaume; Bodero, Lizeth; Marhadour, Sophie; Nourrisson, Marie-Renee; Picot, Carine; Ruchaud, Sandrine; Bach, Stephane; Baratte, Blandine; Sauvain, Michel; Pareja, Denis Castillo; Vaisberg, Abraham J.; Le Pape, Patrice; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 381 – 395;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 4858-85-9, A common heterocyclic compound, 4858-85-9, name is 2,3-Dichloropyrazine, molecular formula is C4H2Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 2,3-dichloro compound (1, 1.256 mmol), 10% Pd/C (0.0125 mmol), CuI (0.0125 mmol), PPh3 (0.0502 mmol) and Et3N (1.8844 mmol) in EtOH (4 mL) was stirred for 15 min. To this was added an appropriate terminal alkyne (2, 1.256 mmol), under a nitrogen atmosphere and the mixture was stirred at 60 C for 2-4 h. After completion of the reaction, the mixture was diluted with EtOAc (3 x 10 mL). The organic layers were collected, combined, washed with cold water (2 x 15 mL), dried over anhydrous Na2SO4, filtered and concentrated under vacuum. The crude product was then purified by column chromatography on silica gel using EtOAc / n-hexane as a solvent system.

The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kolli, Sunder Kumar; Nakhi, Ali; Medishetti, Raghavender; Yellanki, Swapna; Kulkarni, Pushkar; Ramesh Raju; Pal, Manojit; Bioorganic and Medicinal Chemistry Letters; vol. 24; 18; (2014); p. 4460 – 4465;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 4858-85-9, These common heterocyclic compound, 4858-85-9, name is 2,3-Dichloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 2,3-dichloropyrazine (500 mg, 3.35 mmol), 4-chlorophenyl boronic acid (472 mg, 3.02 mmol) and sodium carbonate monohydrate (1.2 g, 10.05 mmol) in a mixture of DMSO and water (10 mL, 3 : 1) was added [1,1 ‘- bis(diphenylphosphino)ferrocene]dichloropalladium (II) (122 mg, 0.16 mmol) at RT. The reaction mixture was degassed and bubbled with nitrogen thrice before heating at 80 C for 16 h. The mixture was cooled to RT and diluted with ethyl acetate (30 mL). The organic solution was washed with water (30 mL) and brine (30 mL). The solvent was removed under reduced pressure and the residue obtained was purified by silica gel column chromatography to obtain 320 mg of the desired product; 1H NMR (300 MHz, CDC13) delta 7.47 (d, J = 12 Hz, 2H), 7.76 (d, = 7.2 Hz, 2H), 8.35 (d, = 1.8 Hz, 1H), 8.58 (d, = 1.8 Hz, 1H).

The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; DAS, Sanjib; GHARAT, Laxmikant Atmaram; HARDE, Rajendra Laxman; SHELKE, Sandeep Yadunath; PARDESHI, Shailesh Ramesh; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; BAJPAI, Malini; (181 pag.)WO2017/21879; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

4858-85-9, name is 2,3-Dichloropyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2,3-Dichloropyrazine

Step 1: 2-chloro-3-hydrazinylpyrazi [0196] To a stirred solution of 2,3-dichloropyrazine (10.0 g, 67.6 mmol) in ethanol (95%, 120 ml) was added 85% hydrazine hydrate (25.6 mL, 338 mmol) dropwise at room temperature. The mixture was stirred for 4 hours and cooled to ice-water bath temperature. The resulting precipitate was isolated by filtration and washed with cold ethanol (95%) to give the title compound as a light yellow powder (6.5 g, 67%) which was used in the next step without further purification.

The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4858-85-9 as follows. Product Details of 4858-85-9

STEP1 Preparation of 2-chloro-3-hydrazinylpyrazine To a solution of 2,3-dichloropyrazine (10.0 g, 67.1 mmol) in EtOH (224 mL) was added hydrazine hydrate (6.72 g, 134 mmol) at room temperature. The reaction mixture was refluxed for 3 hours. A precipitated solid was collected by filtration, washed with EtOH and dried under vacuum to afford 2-chloro-3-hydrazinylpyrazine (7.80 g, 80%) as an orange solid. 1H-NMR (DMSO-d6, 400 MHz): delta 8.30 (1H, brs), 8.07 (1H, d, J=2.4 Hz), 7.57 (1H, d, J=2.8 Hz), 4.34 (2H, brs).

According to the analysis of related databases, 4858-85-9, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 4858-85-9, name is 2,3-Dichloropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4858-85-9, Recommanded Product: 2,3-Dichloropyrazine

Hydrazine hydrate (20 mL, 43.6 mmol) was slowly added dropwise to a solution of 2,3-dichloropyrazine (3.2 g, 21.8 mmol) in ethanol (600 mL).The temperature was raised to reflux for 1.5 hours, and the mixture was dried under reduced pressure.The solid is added to the water and filtered.The solid was recrystallized twice in ethanol to give a yellow solid(2.68 g, yield 85%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Dichloropyrazine, and friends who are interested can also refer to it.

Some common heterocyclic compound, 4858-85-9, name is 2,3-Dichloropyrazine, molecular formula is C4H2Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C4H2Cl2N2

Step 1: 2-Chloro-3-(2-phenoxyethylamino)pyrazine. A mixture of 2-phenoxyethylamine (2.65 g, 19.3 mmol), 2,3-dichloropyrazine (2.88 g, 19.3 mmol) and K2CO3 (2.67 g, 19.3 mmol) in acetonitrile (8 mL) was stirred in a sealed tube for 12 h at room temperature, and for a further 9.5 h at 80 C. The reaction mixture was diluted with ether, filtered, and concentrated. The residue was purified by chromatography on silica gel using n-hexane/EtOAc (7:3) as eluent to give 2.36 g (49%) of the title compound as a yellowish oil that solidified on standing: mp 51-53 C.; HRMS m/z calcd for C12H12ClN30 (M)+249.0669, found 249.0659. Anal. (Cl2H12ClN30) C, H, N.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4858-85-9, its application will become more common.

Reference:
Patent; Biovitrum AB; US6465467; (2002); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 4858-85-9, A common heterocyclic compound, 4858-85-9, name is 2,3-Dichloropyrazine, molecular formula is C4H2Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,3-dichloro-pyrazine (25 g) was dissolved in ethanol (500 mL),Hydrazine monohydrate (16.7 mL) was added, And the mixture was stirred under reflux for 1 hour and a half. Water was added to the reaction solution, and the precipitated solid was dried under reduced pressure after filtering off the resulting solid to give the title compound as white crystals by recrystallization from ethanol (18.12g, 74%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; TAIHO PHARMACEUTICAL COMPANY LIMITED; MINAMIGUCHI, KAZUHISA; OKAJIMA, SHIGEO; AOKI, SHINICHI; ASAI, MASANORI; ASAI, TAKAHIRO; YAMANAKA, HIROYOSHI; DOHI, SUGURU; (149 pag.)JP5851663; (2016); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem