Category: 4774-15-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4774-15-6, name is 2,6-Dimethoxypyrazine, A new synthetic method of this compound is introduced below., COA of Formula: C6H8N2O2

General procedure: A magnetically stirred solution of xanthate (2.0 equiv) and pyrazine (1.0 equiv) in 1, 2-dichloroethane (1.0mmol/mL according to the xanthate) was refluxed for 15min under a flow of nitrogen. Then dilauroyl peroxide (DLP) was added portionwise (20mol % according to the xanthate) every hour until total consumption of one substrate. The reaction mixture was then cooled to room temperature and the solvent was evaporated under reduced pressure. Unless otherwise specified, the crude product was purified by flash chromatography on silica gel.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Huang, Qi; Qin, Ling; Zard, Samir Z.; Tetrahedron; vol. 74; 40; (2018); p. 5804 – 5817;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 4774-15-6, These common heterocyclic compound, 4774-15-6, name is 2,6-Dimethoxypyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

20 ml of 30% hydrogen peroxide was slowly added to 20 ml of acetic acid at room temperature, and then 4 g of 2,6-dimethoxypyrazine was added to the above oxidizing agent solution.After it is dissolved, the reaction system is heated to 55 C, and reacted for 4 hours; after the reaction is completed, the reaction system is cooled to room temperature and poured into ice water;The mixture was extracted 9 times with ethyl acetate.After the solid was filtered off, the filtrate was evaporated under reduced pressure to remove solvent.The white solid product 2,6-dimethoxypyrazine-4-oxide was obtained in a yield of 68%.

The synthetic route of 4774-15-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China Engineering Physics Institute Chemical Materials Institute; Huang Qi; Li Hongzhen; Nie Fude; (11 pag.)CN107266376; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4774-15-6, name is 2,6-Dimethoxypyrazine, A new synthetic method of this compound is introduced below., Quality Control of 2,6-Dimethoxypyrazine

General procedure: Representative procedure for the preparation of 1-phenoxycarbonyl-2-phenyl-3-methoxy-1,2-dihydropyrazine (3a). To a stirred solution of 2-methoxypyrazine (0.200 g, 1.816 mmol) inanhydrous THF (5 mL) was added phenylchloroformate (0.28 mL, 2.225 mmol) at 0 C andstirring was continued under nitrogen atmosphere until salt formation was completed (15 min, asdetermined by TLC on neutral alumina, EtOAc/hexanes 1:19). The reaction mixture was cooledto -41 C, a 1 M solution of phenylmagnesium bromide in THF (2.4 mL, 2.4 mmol) was addedand the mixture stirred until reaction completion (40 min, as determined by TLC on neutral SiO2,EtOAc/hexanes 1:9), and then quenched with 2 mL of aqueous 20% NH4OH/NH4Cl 1:1 (w/w).The mixture was extracted with dichloromethane (2 × 15 mL), dried over Na2SO4, andconcentrated in vacuo. Purification of the crude mixture by flash silica gel columnchromatography (0-15% EtOAc/hexanes) afforded 3a (0.488 g, 87%) as a white solid (3:2mixture of rotamers): mp: 81-82 C; 1H NMR (CDCl3, 500 MHz) delta 7.49-7.27 (m, 7H), 7.20 (t, J= 7.5 Hz, 1H), 7.12 (d, J = 8.0 Hz, 1H), 6.99 (d, J = 7.5 Hz, 1H), 6.67 and 6.63 (2d due torotamers, J = 5.5 Hz, 1H), 6.16 and 6.14 (2d due to rotamers, J = 5.0 Hz, 1H), 5.89 and 5.87 (2sdue to rotamers, 1H), 3.84 and 3.83 (2s due to rotamers, 3H); 13C NMR (CDCl3, 125 MHz) delta160.2, 160.0, 151.6, 151.5, 150.7, 150.4, 136.8, 135.9, 129.3, 128.8, 128.7, 128.6, 127.2, 126.6,125.9, 125.8, 121.3, 118.2, 118.1, 112.5, 111.8, 56.0, 54.6, 54.0, 53.9; HRMS (ESI) m/z calcdfor C18H17N2O3 [M + H]+ 309.12337, found 309.123554

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; St Hilaire, Valentine R.; Hopkins, William E.; Miller, Yenteeo S.; Dandepally, Srinivasa R.; Williams, Alfred L.; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 72 – 78;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 4774-15-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4774-15-6, name is 2,6-Dimethoxypyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

the molar ratio of Sodiummethoxide and dibromopyrazine is 5:1 placed into three-necked flask with astirrer and a thermometer, added 500ml of Distilled water, start the mixer andwith speed of 200r / min it was stirredfor 10min; After the mixing the mixture was placed at reflux apparatus , heatedup to 60 C, refluxed for 2h, , the collected reflux liquid was put into abeaker then placed in an ice-water bath , at 4 C under ice the precipitatewas allowed to stand for 2h, filtered toobtain precipitate and spare after rotary evaporation drying; The massconcentration of concentrated sulfuric acid is 98% and after drying as mentioned above the precipitatemass ratio is 12: 1 were mixed andtogether poured into a beaker of 500mL, after stirred with a glass rod for10min placed on the shaker and Oscillating reaction for 2 h ,then againadded 50mL of nitric acid solution with a mass concentration of 95% , continues to oscillate the reaction for 20minto obtain a mixed solution; The ratio of the mixed liquid and ammonia water is1:5, the ammonia water was poured into the above mentioned mixed solution, placedthe reaction solution on a magnetic stirrer, with speed of 600r / min it was stirred for 10s , afterwards reduce speed to200r / min and continue to stir for 30min. After completion of the stirring,400ml of anhydrous ethanol added into the mixture solution, placed intoultrasonic vibration device, ultrasonic vibration reaction for 1h, thentransferred to a distillation apparatus, heated to 60 C, ethanol was removedby distillation,for drying used vacuum freeze-drying machine and after crushingof solid particles; Take 1g of the above mentioned solid particles and put into100ml of beaker , added 15ml of glacial acetic acid and 10ml of hydrogenperoxide with a mass concentration of 30%, water bath warmed to 40 C, andafter the 6hrs of reaction filtrated to obtain precipitate and dried to obtain 2,6-diamino-3,5-dinitro-1-oxidepyrazine.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dimethoxypyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Changzhou University; CHEN, Xing-quan; (5 pag.)CN105399690; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem