Category: 476622-89-6

Application of 476622-89-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 476622-89-6, name is 5-Bromo-2-iodo-3-methoxypyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Step 1 . Synthesis of 5-bromo-3-methoxy-2-(4-methyl-1 /-/-imidazol-1 – yl)pyrazine (C11 ). A solution of 5-bromo-2-iodo-3-methoxypyrazine (which may be prepared according to Garg, N . K. et al., J. Am. Chem. Soc. 2002, 124, 13179- 13184) (92 g, 0.29 mol), 4-methyl-1 H-imidazole (38.5 g, 0.47 mol), K3P04 (157 g, 0.74 mol) and trans- ,2-diaminocyclohexane (15 mL, 0.12 mol) in dioxane (300 mL) was heated at reflux under a stream of argon for 15 minutes. Copper(l) iodide (5.5 g, 29 mmol) was added, and the reaction mixture was heated at reflux for an additional 30 minutes. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate (1 .0 L) and chromatographed on silica (Gradient: 0% to 16% methanol in ethyl acetate) to provide the title compound. Yield: 21.7 g, 0.081 mol, 28%. 1 H N MR (400 MHz, CDCI3) delta 2.28 (s, 3H), 4.15 (s, 3H), 7.53 (s, 1 H), 8.08 (s, 1 H), 8.38 (s, 1 H).

The synthetic route of 5-Bromo-2-iodo-3-methoxypyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O’DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani; WO2011/48525; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 476622-89-6, name is 5-Bromo-2-iodo-3-methoxypyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 476622-89-6

General procedure: In a Schlenk flask, a solution containing the haloheterocycle (1mmol), the boronic acid (1.3mmol), methanol (5mL) and a 2M aqueous sodium carbonate solution (3.35mmol) in benzene (25mL) was deoxygenated by bubbling a stream of argon through it. Pd(PPh3)4 (0.14mmol) was then added and the flask was evacuated and purged with argon. The reaction mixture was heated for the time indicated and the reaction was quenched with water and extracted with CH2Cl2 (3¡Á). The combined organic extracts were dried over Na2SO4, filtered and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel as indicated.

The synthetic route of 5-Bromo-2-iodo-3-methoxypyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Garcia-Rodriguez, Jose; Perez-Rodriguez, Santiago; Ortiz, Maria A.; Pereira, Raquel; De Lera, Angel R.; Piedrafita, F. Javier; Bioorganic and Medicinal Chemistry; vol. 22; 4; (2014); p. 1285 – 1302;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 476622-89-6,Some common heterocyclic compound, 476622-89-6, name is 5-Bromo-2-iodo-3-methoxypyrazine, molecular formula is C5H4BrIN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a Schlenk flask, a solution containing the haloheterocycle (1mmol), the boronic acid (1.3mmol), methanol (5mL) and a 2M aqueous sodium carbonate solution (3.35mmol) in benzene (25mL) was deoxygenated by bubbling a stream of argon through it. Pd(PPh3)4 (0.14mmol) was then added and the flask was evacuated and purged with argon. The reaction mixture was heated for the time indicated and the reaction was quenched with water and extracted with CH2Cl2 (3×). The combined organic extracts were dried over Na2SO4, filtered and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel as indicated.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-2-iodo-3-methoxypyrazine, its application will become more common.