Category: 446286-94-8

Electric Literature of 446286-94-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 446286-94-8, name is 5-Bromo-N,N-dimethylpyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To asolution of dimethyl amino 3d (1370 mg, 6.82mmol) in drytetrahydrofuran (50 mL) under Ar at 80 C was slowly added1.57M n-butyllithium hydride (n-BuLi) in hexane (10.8 mL).After stirring for 60min at 80 C, to the mixture was addedN,N-dimethylformamide (DMF) (2.0 mL, 26mmol) and theresulting solution was allowed to warm to r.t. After stirring for1 h, to the reaction mixture was added water to decompose theexcess reducing agent. Further, to the mixed solution was addedwater followed by extraction with ethyl acetate (3 200 mL).The combined organic layers were dried over Na2SO4, filtered,and the solvents were removed under reduced pressure. Theresidue obtained was purified by silica gel column chromatography(hexane/ethyl acetate = 1/1) to yield arylaldehyde 4d (975 mg, 6.46mmol, 95%) as a light yellow solid: mp 112 C;IR (neat, , cm1): 2783, 1681, 1373, 1008; 1HNMR (500MHz, CDCl3) 9.91 (s, 1H), 8.69 (s, 1H), 8.08 (d, J = 1.1 Hz,1H), 3.26 (s, 6H); 13CNMR (126 MHz, CDCl3) 190.7, 155.5,144.3, 136.8, 129.4, 37.9; HR-ESI-MS: m/z: [M+ H]+ calculatedfor C7H10N3O, 152.0824; found, 152.0814.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-N,N-dimethylpyrazin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Saito, Ryohei; Kuchimaru, Takahiro; Higashi, Shoko; Lu, Shijia W.; Kiyama, Masahiro; Iwano, Satoshi; Obata, Rika; Hirano, Takashi; Kizaka-Kondoh, Shinae; Maki, Shojiro A.; Bulletin of the Chemical Society of Japan; vol. 92; 3; (2019); p. 608 – 618;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 446286-94-8, name is 5-Bromo-N,N-dimethylpyrazin-2-amine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C6H8BrN3

EXAMPLE 2 P N-(4-(5-(dimethylamino) pyrazin-2-ylsulfonyl) benzyl) imidazo [1, 2-al pyridine-6-carboxamidea. N-f4-f5-fdimethylamino)pyrazin-2-ylsulfonyl)benzyl) acetamide:The mixture of XANTPHOS (0.573 g, 0.990 mmol), Cs2C03 (6.45 g, 19.80 mmol), Pd2(dba)3 (0.453 g, 0.495 mmol),4-(acetamidomethyl)benzenesulfinic acid, sodium salt (3.51 g, 14.85 mmol), 5-bromo-N,N-dimethylpyrazin-2-amine (2 g, 9.90 mmol) in Toluene (50 ml) was degassed and heated to 120 C for overnight. Cooled to RT, added EtOAc, washed with water, dried and concentrated, The Biotage purification afforded 1.6g of the target compound (48%).1HNMPv (CDC13): delta 8.75(s, 1H). 8.03 (s, 1H), 7.87 (d, 2H), 7.38 (d, 2H), 6.11 (b, 1H), 4.45 (d, 2H), 3.21 (s, 6H), 2.16 (s, 3H).

The synthetic route of 446286-94-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FORMA THERAPEUTICS, INC.; GENENTECH, INC.; BAIR, Kenneth, W.; BAUMEISTER, Timm; BUCKMELTER, Alexandre, J.; CLODFELTER, Karl, H.; DRAGOVICH, Peter; GOSSELIN, Francis; HAN, Bingsong; LIN, Jian; REYNOLDS, Dominic J.; ROTH, Bruce; SMITH, Chase, C.; WANG, Zhongguo; YUEN, Po-Wai; ZHENG, Xiaozhang; WO2012/31197; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 446286-94-8, name is 5-Bromo-N,N-dimethylpyrazin-2-amine, A new synthetic method of this compound is introduced below., category: Pyrazines

2-dimethylamino-5-bromo-pyrazine (21) (1.37g, 6.8mmol) was dissolved in dehydrated tetrahydrofuran (THF) (50ml), it was under an argon atmosphere. The solution was cooled to -80 C. with acetone bath, 1.57 M n-butyl lithium (n-BuLi) slowly added hexane solution (10.8 ml), and stirred for 1 hour. Then it was slowly added N, N-dimethylformamide (DMF) (2.0ml, 26mmol) to this mixed solution was stirred for 1 h allowed to warm to room temperature. Then stirred for 15 minutes Water was added to the reaction mixture and extracted with ethyl acetate (2 ¡Á 200ml). The organic layers were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography [silica gel 46.9g; hexane – ethyl acetate (1: 1)] and purified by, 5-aldehyde-2-dimethyl-amino-pyrazine (22) (975mg, 6.5mmol, 95 %) as a light yellow powder solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; UNIVERSITY OF ELECTRO-COMMUNICATIONS; MAKI, SHOJIRO; NIWA, HARUKI; (25 pag.)JP2015/193584; (2015); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 446286-94-8, name is 5-Bromo-N,N-dimethylpyrazin-2-amine, A new synthetic method of this compound is introduced below., COA of Formula: C6H8BrN3

2-dimethylamino-5-bromo-pyrazine (21) (1.37g, 6.8mmol) was dissolved in dehydrated tetrahydrofuran (THF) (50ml), it was under an argon atmosphere. The solution was cooled to -80 C. with acetone bath, 1.57 M n-butyl lithium (n-BuLi) slowly added hexane solution (10.8 ml), and stirred for 1 hour. Then it was slowly added N, N-dimethylformamide (DMF) (2.0ml, 26mmol) to this mixed solution was stirred for 1 h allowed to warm to room temperature. Then stirred for 15 minutes Water was added to the reaction mixture and extracted with ethyl acetate (2 ¡Á 200ml). The organic layers were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography [silica gel 46.9g; hexane – ethyl acetate (1: 1)] and purified by, 5-aldehyde-2-dimethyl-amino-pyrazine (22) (975mg, 6.5mmol, 95 %) as a light yellow powder solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; UNIVERSITY OF ELECTRO-COMMUNICATIONS; MAKI, SHOJIRO; NIWA, HARUKI; (25 pag.)JP2015/193584; (2015); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem