Category: 426829-61-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 426829-61-0, name is N-Benzyl-6-chloropyrazin-2-amine, A new synthetic method of this compound is introduced below., Safety of N-Benzyl-6-chloropyrazin-2-amine

General procedure: The Miyaura borylation reactions were carried out as follows: Chloropyrazines (3.0 mmol), B2pin2 (838 mg, 3.3 mmol), Pd(OAc)2 (14 mg, 2 mol %), PCy3 (34 mg, 4 mol %) and AcOK (750 mg, 7.5 mmol) was added in a 50 ml three necked flask fitted with a condenser, and dioxane (15 ml) was added at last. Then the reaction mixture was stirred at a preheated oil bath 110 oC under nitrogen atmosphere for 10 min. After complete completion of starting material checked by TLC, the reaction was cooled to room temperature, EtOAc (20 ml) was added. After filtration through Celite and concentration under vacuo, the resulting residue was precipitated from n-hexane:Et2O to afford corresponding boronic esters.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Lu, Hongtao; Wang, Shengqiang; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie; Tetrahedron Letters; vol. 58; 9; (2017); p. 839 – 842;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 426829-61-0, name is N-Benzyl-6-chloropyrazin-2-amine, A new synthetic method of this compound is introduced below., Computed Properties of C11H10ClN3

Step 2: N-Benzyl-6-(1-Piperazinyl)-2-Pyrazinamine. A mixture of the product from step 1 above (1.25 g, 5.7 mmol), piperazine (1.0 g, 11.6 mmol), and K2CO3 (1.0 g, 7.3 mmol) in dioxane (3 mL) was heated at 160 C. for 11 h in a sealed pyrex flask. The reaction mixture was diluted with dichloromethane, filtered and concentrated in vacuo. The red-brownish residue was dissolved in a small volume of CHCl3/MeOH (9:1) and purified by silica gel chromatography (15 *4 cm) using CHCl3/MeOH (95:5, followed by 9:1) as eluent. The free base was obtained as a brownish solid (0.9 g, 3.33 mol) that was redissolved in methanol (10 mL). Maleic acid (0.45 g, 3.83 mmol) in methanol (5 mL) was added and the salt was precipitated out by addition of ether. The salt was recrystallized from MeOH-ether and finally converted back to the free base by alkalinization (10% aqueous Na2CO3) and extraction with ether (5*60 mL). The combined ether layers were dried (K2CO3), filtered and concentrated. This furnished 0.36 g (23%) of the title compound as a light yellow powder. HRMS m/z calcd for C15H19N5(M)+269.1640, found 269.1641. Anal. (C15H19N5) C, H, N.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nilsson, Bjorn M.; US2002/147200; (2002); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 426829-61-0, name is N-Benzyl-6-chloropyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C11H10ClN3

To a stirred solution of benzimidazole (130mg, 1. LMMOL) in anhydrous DMF (5mL) at 0C under N2 was added sodium hydride (56mg, 60% dispersion in oil, 1. 45MMOL) in portions over 2 min. The mixture was stirred at 0C for 15 min and at RT for 60 min. To this was added a solution of (6-CHLORO-PYRAZIN-2-YL)- (L-BENZYL)-AMINE (220mg) in DMF (5mL) and the resulting mixture was then heated at reflux for 18h. The DMF was removed under reduced pressure and the residue diluted with chloroform. The organic layer was washed with water, dried (Na2SO4) and the solvent removed under reduced pressure to furnish the crude product. Column chromatography using dichloromethane-methanol (20: 1 < 10: 1) as eluant separated the product (100mg). H-N. m. r. (CD3) 8 4.66 (d, 2H, J= 5.7Hz, CH2), 5.56 (m, 1H, NH), 7.29-7. 39 (m, 7H, Ar-H), 7.78-7. 89 (m, 2H, Ar-H), 7.92 (s, 1H, pyraz-H), 8.16 (s, 1H, pyraz-H), 8.48 (s, 1H, benzimid-H2). m/z (ES) 302 (M++H). Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 426829-61-0. Reference:
Patent; CYTOPIA PTY LTD; WO2003/99811; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem