Category: 41270-66-0

Some common heterocyclic compound, 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine, molecular formula is C16H11ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 41270-66-0

Under the protection of nitrogen,Add 3-methyl-2-chloro-quinoxaline (532 mg, 2.00 mmol) to cis-5-(isopropylaminomethyl)tetrahydrofuran-2-yl)methanol (1.04 g, 6.00 mmol)N-methylpyrrolidone(50mL) solution,The reaction was heated to 190 C for 15 h, and the reaction was monitored by LC-MS.The reaction was cooled, and ice water was added to the mixture, and ethyl acetate (50mL*3)The organic mixed phase was washed with water (50 mL) and saturated brine (50 mL*2).Filtration, solvent removal under reduced pressure, purification by chromatography on silica gel column, and collected under reduced pressure.Drying in vacuo gave 641.5 mg of Compound VIII as a white solid.Yield: 79.6%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 41270-66-0, its application will become more common.

Reference:
Patent; Chengdu Yuandong Bio-pharmaceutical Co., Ltd.; Zeng Yanqun; Yan Shengyong; Zhang Tao; Wang Ying; (17 pag.)CN108623541; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

41270-66-0, Name is 5-Chloro-2,3-diphenylpyrazine, 41270-66-0, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

2-[4-(tert-butoxycarbonyl)(isopropyl)aminobutoxy]-N-(methylsulfonyl)acetamide (20.0 g, 0.055 mol)And dissolved in methanol (110 mL),Trifluoroacetic acid (6.8 g, 0.06 mol) was added and the reaction stirred at 65 C for 6 hours until the reaction was complete. The reaction mixture was added dropwise to stirred water (200 mL), cooled to 0 C for 3 hours and filtered to give the intermediate compound 2- [4- (isopropyl) aminobutoxy] -N- (methylsulfonyl) acetamide) and then dissolved in methanol (40 mL)5-Chloro-2,3-diphenylpyrazine (16.0 g, 0.06 mol)N, N-diisopropylethylamine (15.5 g, 0.12 mol),The reaction mixture was stirred for 8 hours at 100 C. The reaction mixture was allowed to cool to room temperature. Water (40 mL) was added and the mixture was cooled to -10 C for 3 hours. The resulting mixture was filtered to give a solution of celecoxib (25.0 g) , The reaction of this step is as follows

Statistics shows that 5-Chloro-2,3-diphenylpyrazine is playing an increasingly important role. we look forward to future research findings about 41270-66-0.

Reference:
Patent; Hunan Ouya Biological Co., Ltd.; Li Xingmin; (10 pag.)CN105949135; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem