Category: 41270-66-0

Related Products of 41270-66-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41270-66-0 name is 5-Chloro-2,3-diphenylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3: 2-Azido-5,6-diphenylpyrazine. To a stirred solution of 2-Chloro-5,6-diphenylpyrazine (45 mg, 0.17 mmol) in 500 muL DMF at room temperature under nitrogen was added sodium azide (11 mg, 0.17 mmol) and the reaction was warmed to 100 C. After stirring overnight, the reaction was cooled to room temperature, diluted with EtOAc (30 mL) and washed 4*30 mL with H2O and 1*30 mL with saturated NaCl. The organics were islolated, dried (MgSO4), filtered and concentrated to the 2-azidopyrazine, which exists as a yellow solid (45 mg, quantitative). 1H-NMR (400 MHz, CDCl3) delta9.73 (s, 1H), 7.58-7.42 (m, 6H), 7.36-7.23 (m, 4H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-2,3-diphenylpyrazine, and friends who are interested can also refer to it.

Reference:
Patent; Keegan, Kathleen S.; Kesicki, Edward A.; Gaudino, John Joseph; Cook, Adam Wade; Cowen, Scott Douglas; Burgess, Laurence Edward; US2003/69284; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 41270-66-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To the stirred mixture of 5-chloro 2-3 diphenyl pyrazine (100 g, 0.375 mol) & 4-lsopropylamino-butyric acid ethyl ester (257.97 g, 1.49 mol) was added at room temperature. Reaction mixture was stirred at 185-190C temperature for 24 hr. Reaction was monitored by HPLC analysis. After completion of reaction, charged purified Water and product extracted in Ethyl acetate, which was washed using 5% sodium bicarbonate to remove the hydroxyl impuritiy produced during the reaction. Then the ethyl acetate layer was concentrated to obtain the 4-[(5,6-diphenyl-pyrazin-2-yl)-isopropyl-amino]- butyric acid ethyl ester. [Yield = 90 g; Purity (HPLC) = 88.71 %]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-2,3-diphenylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MEGAFINE PHARMA (P) LTD.; MATHAD VIJAYAVITTHAL THIPPANNACHAR; DODDAPPA PRALHAD ANEKAL; KARDILE PRITESH BHIMRAJ; PADAKI SANTHOSH AMBADAS; GAIKWAD BAPUSAHEB SHRIHARI; SHINDE GORAKSHANATH BALASAHEB; (63 pag.)WO2017/42828; (2017); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41270-66-0, Recommanded Product: 5-Chloro-2,3-diphenylpyrazine

5 gm of 2-chloro-5,6-diphenylpyrazine (IV) in 25 ml N-Methyl-2-pyrrolidone (NMP) and 5.18 gm of K2CO3 were mixed with 9.92 gm of 4-(isopropylamino)-l-butanol (III), the reaction mixture was then heated with stirring at 150-155 C for 20-21 hrs. The reaction solution was air-cooled, poured into 25 ml water, extracted with 20 ml ethyl acetate. Aqueous layer washed with 10 ml ethyl acetate. Ethyl acetate layers are combined and washed with 15 ml of water, dried over anhydrous magnesium sulfate and then concentrated to obtain 6.3 gm of residue. 6 gm of the residue was purified by silica gel column chromatography by eluting with 2000 ml hexane and 550 ml ethyl acetate to obtain solid 3.2 gm of the desired compound. Yield: 49.41 %

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; LUPIN LIMITED; RAY, Purna, Chandra; KUMAR, Gaurav; SHABADE, Samir, Shanteshwar; RASHINKAR, Dattatray, Bajirao; ARORA, Surinder, Kumar; SINGH, Girij, Pal; (23 pag.)WO2017/60827; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 41270-66-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Add 2-butanone (1440 ml) to the reaction flask,Sodium iodide (134.87g, 2.5 eq),2-chloro-5,6,-diphenylpyrazine (96 g, 1.0 eq),Nitrogen protection. Concentrated sulfuric acid (14.41 g, 0.4 eq) was added dropwise at room temperature. After the addition is completed, the temperature is raised toThe reaction was refluxed for 6 hours. After the reaction is completed,The reaction solution was concentrated to dryness. Add water (960ml),Dichloromethane (960 ml), liquid. The organic phase was concentrated to dryness filter,The solid is dried under reduced pressure,2-iodo-5,6,-diphenylpyrazine (88 g), yield 68.2%

The synthetic route of 5-Chloro-2,3-diphenylpyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Kesheng Pharmaceutical Research And Development Co., Ltd.; Zhejiang Huahai Pharmaceutical Co., Ltd.; Liu Huixin; Shen Junhui; Zhang Jicheng; Huang Luning; Tao Anping; An Jianguo; Chen Qian; Gu Hong; (10 pag.)CN109384734; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 41270-66-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 41270-66-0 as follows.

30 g of 2-chloro-5,6-diphenylpyrazine and 131.22 g of 4-(isopropylamino)-1-butanol were mixed and then heated with stirring at 190C for 10 hours.. The reaction solution was air-cooled, poured into water, extracted with diethyl ether, dried over anhydrous magnesium sulfate and then concentrated.. The residue was purified by silica gel column chromatography to obtain 22.96 g of the desired compound as a colorless crystal having a melting point of 102 to 103C.

According to the analysis of related databases, 41270-66-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nippon Shinyaku Co., Ltd.; EP1400518; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 41270-66-0, A common heterocyclic compound, 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine, molecular formula is C16H11ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 5-Chloro-2,3-diphenyl-pyrazine (10.00 g, 37.5 mmol) and a 70% solution of isopropylamine in water (44.32 g, 74.9 mmol) in isopropanol (100 ml) was heated at 150 C for 24 h in a autoclave with 200-400 psi pressure. The reaction progress was monitored by HPLC and after completion of reaction; resulting mass was cooled to 25-30 C and concentrated. The residue was diluted with water and extracted with dichloromethane, after which the extract was distilled completely to obtain solid (5,6-diphenyl- pyrazin-2-yl)-isopropyl-amine (7.0g, 76%) as pale yellowish solid. [Yleld= 7g]

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MEGAFINE PHARMA (P) LTD.; MATHAD VIJAYAVITTHAL THIPPANNACHAR; DODDAPPA PRALHAD ANEKAL; KARDILE PRITESH BHIMRAJ; PADAKI SANTHOSH AMBADAS; GAIKWAD BAPUSAHEB SHRIHARI; SHINDE GORAKSHANATH BALASAHEB; (63 pag.)WO2017/42828; (2017); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

41270-66-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine, This compound has unique chemical properties. The synthetic route is as follows.

Trimethylamine (33% ethanol solution, 358 g, 2.0 mol) was added to ethyl acetate (1.3 L) of 5-chloro-2,3-diphenylpiperazine (266 g, 1.0 mol)And stirred at room temperature for 48 hours.A large number of solids are present.filter,The solid was washed with ethyl acetate (2 x 50 mL)Dried in high vacuum to give 283.5 g of a white solid,The yield was 87%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Suzhou Guohang Pharmaceutical Technology Co., Ltd.; Mei, Desheng; (11 pag.)CN106467496; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

41270-66-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To the stirred mixture of 5-chloro 2-3 diphenyl pyrazine (100 g, 0.375 mol) & 4-isopropyl amino butane-1-ol (172.17 g, 1.31 mol) was added at room temperature. The resultant reaction mixture was heated at 180-185C and maintain at same temperature for 24 hrs. After completion of reaction by HPLC analysis, cool the reaction mass and diluted it with ethyl acetate (1000 ml), purified water (1500 ml) and product was extracted : in ethyl acetate further aqueous layer was rewashed with ethyl acetate (500 ml). After combining the both ethyl acetate layers, wash it with 5% sodium bicarbonate (1000 ml) to remove the hydroxyl impurity formed during the reaction followed by washing of 10% sodium chloride solution (1000 ml). Ethyl acetate layer was concentrated under reduced pressure to obtain thick syrup of compound (4). Obtained thick syrup was diluted with ethyl acetate (20 ml) and n-heptane (500 ml) was added to the diluted mass and stirred for 60-90 min. the resultant isolated solid was filtered and washed with n-heptane (100 ml), suck dried and dried the solid under vacuum at 35-40 C for 3-4 hrs. [Yield = 95.0 g; Purity (HPLC) = 91.5%]

The synthetic route of 5-Chloro-2,3-diphenylpyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MEGAFINE PHARMA (P) LTD.; MATHAD VIJAYAVITTHAL THIPPANNACHAR; DODDAPPA PRALHAD ANEKAL; KARDILE PRITESH BHIMRAJ; PADAKI SANTHOSH AMBADAS; GAIKWAD BAPUSAHEB SHRIHARI; SHINDE GORAKSHANATH BALASAHEB; (63 pag.)WO2017/42828; (2017); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

41270-66-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41270-66-0 name is 5-Chloro-2,3-diphenylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

6 g of the compound of the formula (1), 7 g of isopropylamine and 5 mL of dimethyl sulfoxide were placed in a sealed pressure-resistant reaction vessel, and the mixture was heated to 90 C for 48 hours, and the reaction was completed. The reaction solution was cooled to 25 C, then 18 mL of ethanol was added, and the solution was dissolved at 80 C, then 24 mL of water was added dropwise over 1 h, a large amount of solid was precipitated, and the temperature was lowered to 25 C, stirred for 0.5 hour, and suction-filtered to obtain a solid.Drying at 80 C for 24 h under vacuum gave 6 g of the compound of formula (2) as a pale yellow solid.The yield was 92.3%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-2,3-diphenylpyrazine, and friends who are interested can also refer to it.

Reference:
Patent; Dongguan Dongyangguang Pharmaceutical Research And Development Co., Ltd.; Liu Yongjun; Wang Zhongqing; Liao Shouzhu; Luo Zhonghua; (5 pag.)CN109422698; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

41270-66-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine, A new synthetic method of this compound is introduced below.

2-chloro-5,6-diphenylpyrazine (10 gm), 4-(isopropylamino)-1 -butanol (44 gm) and N-methylpyrrolidine (50 mL) were charged into a 250 mL round bottom flask at 30C. The reaction mass was heated to 190C and stirred for 10 hours. The reaction mass was cooled to 30C and poured into cold water, extracted with ethylacetate, dried over anhydrous magnesium sulphate and then concentrated to get 9 gm of the title compound.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DR. REDDY’S LABORATORIES LIMITED; ORUGANTI, Srinivas; KANDAGATLA, Bhaskar; DAHANUKAR, Vilas Hareshwar; CHINTADA, Krishnarao; SHAIKH, Latif Jafar; YARRAGUNTLA, Sesha Reddy; PEDDIREDDY, Subba Reddy; KOTTUR, Mohan Kumar; (33 pag.)WO2017/29594; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem