Synthetic Route of 4121-22-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4121-22-6 as follows.
A solution of 5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde (75mg, 0.51mmol), Cs2CO3 (3eq, 500mg), and 3-methoxybenzyl bromide (1.2eq, 0.087mL) in DMF (6mL) was stirred at 25C for 15h. The reaction was diluted with EtOAc and washed with peta7 buffer (2x). The organic layer was dried over Na2SO4 and concentrated. The residue was purified via flash chromatography eluding with a gradient of 0 – 100% EtOAc/hexanes. 5-(3- methoxybenzyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde was isolated as a yellow solid. 1H NMR (500 MHz, CDCl3): delta 10.25 (s, IH), 8.65 (d, IH), 8.40 (d. IH), 8.12 (s, IH), 7.29 (t, IH), 6.80 (d, IH), 6.83 (m, IH), 5.48 (d, 2H), 3.78 (s, 3H).
According to the analysis of related databases, 4121-22-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK & CO., INC.; WO2009/5672; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem