Category: 41110-34-3

Synthetic Route of 41110-34-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41110-34-3, name is Ethyl 5-methylpyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 5-methyl-2-pyrazinecarboxylic acid ethyl ester (2) (0.01 mol) and hydrazine hydrate (0.02mol) in ethyl alcohol (20 mL) was refluxed for 3 h with consistent stirring. After realization of the reaction (examined by the TLC), the reaction mixture is cooled to room temperature and filtered. The crude product was recrystallized from ethanol to offer pure 5-methyl-2-pyrazine carboxylic acid hydrazide (3).

The synthetic route of Ethyl 5-methylpyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Maddireddi, Chandra Sekhara Reddi; Parimi, Uma Devi; Reddy, Sreenivasa Reddy Bhimi; Mandapati, Satyanarayana Reddy; Asian Journal of Chemistry; vol. 28; 11; (2016); p. 2453 – 2456;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 41110-34-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41110-34-3, name is Ethyl 5-methylpyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Preparative Example 1 5.40 g of ethyl 5-methylpyrazine-2-carboxylate was dissolved in 54.0 mL of carbon tetrachloride, and 5.78 g of 1-bromosuccinimide and 267 mg of 2,2′-azobis(isobutyronitrile) were added thereto, followed by heating with reflux for 3 hours. The reaction liquid was left to be cooled to room temperature and then concentrated under reduced pressure, and the obtained residue was suspended in 100 mL of ethyl acetate and the insoluble materials were separated by filtration. The filtrate was washed with a saturated aqueous sodium hydrogen carbonate solution, water, and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated and the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1 to 1:1) to obtain 2.62 g of ethyl 5-(bromomethyl)pyrazine-2-carboxylate.

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-methylpyrazine-2-carboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Astellas Pharma Inc.; EP2305641; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41110-34-3, name is Ethyl 5-methylpyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Ethyl 5-methylpyrazine-2-carboxylate

Ethyl 5-methyl-2-pyrazinecarboxylate (10.0 g, 60.18 mmol), benzoyl peroxide (1. 46 g, 6. 02 mmol) and N-bromo succinimide (11. 78 g, 66. 19 mmol) in 80 mL CCl4 was heated to reflux while a 75W tungsten lamp was shining on the reaction mixture. After 4h the reaction mixture was cooled and the precipitate filtered off. The red filtrate was concentrated and the residue redissolved in EtOAc and washed with sat’d NaHC03, 5% Na2S203, brine and the organics dried (Na2SO4), filtered and concentrated. Chromatography on silica gel using 1: 1 Hexanes: EtOAc eluted the product. After concentration the title compound (6.64 g, 27.08 mmol, 45% yield) was isolated as a yellow oil :’H NMR (CDC13, 400 MHz) 8 9.22 (s, 1H), 8.80 (s, 1H), 4. 58 (s, 2H), 4.49 (dd, J= 14.3, 7.1 Hz, 2H), 1.43 (t, J= 7.2 Hz, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2003/76440; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 41110-34-3, These common heterocyclic compound, 41110-34-3, name is Ethyl 5-methylpyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The reaction was carried out, under nitrogen, in a 500 mL¡Á4 neck flask equipped with a mechanical stirrer, water condenser (with gas inlet), and a thermocouple. The reactor was charged with sodium tungstate dihydrate (1.35 g) and water (30 g). The mixture was stirred to dissolve the solid (10 minutes). Aqueous sulfuric acid (50%) was added bringing the pH down to about 3.5. Aqueous 35% hydrogen peroxide (22.36 g) was added and the solution was stirred for 15 minutes. 5-Methylpyrazinecarboxylic acid ethyl ester (27.27 g) was then added. The reaction mixture was warmed to 70 C. and then stirred for a total of 12 hours after which the reaction was checked by GC or GC/MS and was found to be complete. The resulting solution was concentrated under reduced pressure to yield a light yellow solid. The reaction mixture was cooled in an ice-bath for 3 hours. The product was collected by filtration and washed with ice water (25 g). Drying the solid at 60 C. under house vacuum yielded 20.57 g (69%) of the ester N-oxide.

The synthetic route of 41110-34-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ISP INVESTMENTS INC.; US2005/261312; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem