Category: 41110-33-2

Adding a certain compound to certain chemical reactions, such as: 41110-33-2, name is Methyl 5-methylpyrazine-2-carboxylate, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41110-33-2, name: Methyl 5-methylpyrazine-2-carboxylate

EXAMPLE 3 The reaction is carried out, under nitrogen, in a 1 L¡Á4 neck flask equipped with a mechanical stirrer, water condenser (with gas inlet), and a thermocouple. The reactor is charged with 5-methylpyrazinecarboxylic acid, methyl ester (20.00 g), and methylene chloride (90 g). A solution of OXONE (84.67 g) in water (335 g) is added, and the mixture is vigorously stirred for 68 h at room temperature. The layers are separated, the organic layer is dried over magnesium sulfate, and gravity filtered. The aqueous layer is extracted with methylene chloride (3¡Á135 g). Each extract is poured through the filter containing the magnesium sulfate from above. The extracts are combined and the solvent is removed by distillation at 55 C. Residual solvent is removed under vacuum (25 inches of Hg at 55 C.) yielding 15.39 g (70%) of the n-oxide as an off-white solid).

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Reference:
Patent; ISP INVESTMENTS INC.; US2005/239803; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41110-33-2, name is Methyl 5-methylpyrazine-2-carboxylate belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C7H8N2O2

[0115j To a solution of methyl 5-methylpyrazine-2-carboxylate (0.5 g, 3.28 mmol) in acetic acid (5 ml) was added bromine (0.i9 ml, 3.6i mmol) at room temperature. The reaction mixture was heated at 80C for 45 mm. The reaction mixture was concentrated to remove acetic acid. The residue was basified with saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was dried and concentrated. The crude was purified by silica gel column chromatography using 20% ethyl acetate in hexane to afford the title compound methyl 5-(bromomethyl)pyrazine-2-carboxylate (0.3 g, 40%) as a brownish liquid. Calculated M+H: 230.97; Found M+H: 231.0.

The synthetic route of 41110-33-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MNEMOSYNE PHARMACEUTICALS, INC.; ANDERSON, David R.; VOLKMANN, Robert A.; WO2015/48503; (2015); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41110-33-2, name is Methyl 5-methylpyrazine-2-carboxylate belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Product Details of 41110-33-2

A solution of LAH (164.0 mL, 0.164 mol, 1.0 M in THF, 0.5 equiv.) was added to a suspension of methyl 5-methylpyrazine-2-carboxylate (50 g, 0.328 mol, 1.0 equiv.) in anhydrous THF (750 mL) at -78C. The internal temperature was kept below -72 C during the addition of LAH. On completion of addition, the reaction mixture was left, to stir at -78 C for a further 20 mm and then quenched with glacial AcOH (50.0 mL) at the same temperature. The resulting mixture was warmed to RT and the volatiles were removed by evaporation under pressure. The residue was dissolved in hydrochloric acid (1.5N, 500 mL) and extracted with DCM (2 x 2 L). The extracts were combined, washed with a saturated aqueous sodium hydrogen carbonate solution (2 x 500 mL), (Note: no product was observed in the HC1 or aqueous sodium hydrogen carbonate solution) dried over anhydrous Na2SO4, and concentrated in vacuo to yield a brown oil. The initial product was purified by column chromatography (silica gel 60-120 mesh) eluting with a gradient of 10% EtOAc in petroleum ether to provide the title compound as a pale yellow liquid (21.3 g, 53 %). TLC Info: (9.0/1.0 petroleum ether/EtOAc). 1H NMR (400 MHz, CDC13)o 10.14 (s, 1H), 9.07 (d,J= 1.5 Hz, 1H), 8.63 (d,J= 1.4 Hz, 1H), and 2.70 (s, 3H). LCMS-ESI (pos.) m/z:123 (M+H)t

The synthetic route of 41110-33-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; CHEN, Yinhong; DRANSFIELD, Paul John; HARVEY, James S.; HEATH, Julie Anne; HOUZE, Jonathan; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; NISHIMURA, Nobuko; PATTAROPONG, Vatee; SWAMINATH, Gayathri; YEH, Wen-Chen; RAMSDEN, Philip Dean; (434 pag.)WO2018/93577; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

41110-33-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 41110-33-2 as follows.

A solution of lithium aluminium hydride (164.0 mL, 0.164 mol, 1.0 M in THF, 0.5 equiv.) was added to a suspension of methyl 5-methylpyrazine-2-carboxylate (50 g, 0.328 mol, 1.0 equiv.) in anhydrous THF (750 mL) at -78 C (the internal temperature was kept below -72 C during addition of the lithium aluminium hydride). Upon completion of addition, the reaction mixture was stirred at -78 C for a further 20 mm and then quenched with glacial AcOH (50.0 mL) at the same temperature. The resulting mixture was warmed to RT and the volatiles were removed by evaporation under pressure. The residue was dissolved in 1.5 N HC1 (500 mL) and extracted with DCM (2 x 2 L). The organic layers were combined, washed with saturated aqueous NaHCO3 solution (2 x 500 mL), dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to yield the initial product as a brown oil. The residue was purified by column chromatography (silica gel 60-120 mesh) eluting with a gradient of 10% EtOAc in petroleum ether to provide the title compound as a pale yellow liquid (21.3 g, 53 %). 1H NMR (400 MHz, CDC13) oe 10.14 (s, 1H), 9.07 (d, J= 1.5 Hz, 1H), 8.63 (d, J= 1.4 Hz, 1H), 2.70 (s, 3H). LCMS (ESI positive ion) m/z:123 (M+H)t

According to the analysis of related databases, Methyl 5-methylpyrazine-2-carboxylate, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; BROWN, Matthew; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HOUZE, Jonathan; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YEH, Wen-Chen; (815 pag.)WO2018/97944; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem