Schiesser, Stefan; Hajek, Peter; Pople, Huw E.; Kaeck, Helena; Oester, Linda; Cox, Rhona J. published an article on January 5 ,2022. The article was titled 《Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.SDS of cas: 40972-42-7 The information in the text is summarized as follows:
Inhibition of mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) is a promising strategy to modulate NF-κB signaling, with the potential to treat B-cell lymphoma and autoimmune diseases. The discovery and optimization of (1s,4s)-N,N′-diaryl cyclohexane-1,4-diamines, I [R1 = pyrimidin-4-yl, [2-(trifluoromethyl)pyrimidin-4-yl], (3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl), etc.], II [R2 = [[4-(methylamino)cyclohexyl]amino], (4-aminocyclohexoxy), piperazin-1-yl, etc] and III [R3 = pyrimidin-4-yl, [2-(trifluoromethyl)pyrimidin-4-yl], [3-(trifluoromethyl)phenyl], etc] a novel series of allosteric MALT1 inhibitors, resulting in compound I [R1 = (3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)] with single digit micromolar cell potency was described. X-ray anal. confirms that this compound binds to an induced allosteric site in MALT1. Compound I [R1 = (3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)] was highly selective and has an excellent in vivo rat PK profile with low clearance and high oral bioavailability, making it a promising lead for further optimization. In the experiment, the researchers used 3,6-Dichloroimidazo[1,2-b]pyridazine(cas: 40972-42-7SDS of cas: 40972-42-7)
3,6-Dichloroimidazo[1,2-b]pyridazine(cas: 40972-42-7) belongs to pyrazines. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. SDS of cas: 40972-42-7