Category: 40155-43-9

Related Products of 40155-43-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40155-43-9, name is 5-Aminopyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

In a 100mL one-neck flask, the2-amino-pyrazine carboxylic acid (1.00g, 7.19mmol) was dissolved in DMF (45mL),was added 1- (3-dimethylaminopropylAminopropyl) -3-ethylcarbodiimidehydrochloride (3.51g, 8.95mmol) and diisopropylethylamine amine (2.5mL,14.0mmol), stirred for 15After min, adding1-tert-butoxycarbonyl-piperazine (1.30g, 6.98mmol), the reaction at roomtemperature 15h. After completion of the reaction the organic solvent wasdistilled off under reduced pressure, the residueIt was purified by column chromatography(methylene chloride / methanol (V / V) = 10/1), to give a pale yellow oil(1.85g, 83.70%).

The synthetic route of 5-Aminopyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; East Sunshine Pharmaceutical Co., Ltd.; Liu, Bing; Zhang, Yingjun; Nie, Linlin; Bai, Shun; Zheng, Changchun; Nie, biao; Li, Zhiyong; Tan, Yumei; (61 pag.)CN105294737; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 40155-43-9, name is 5-Aminopyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Aminopyrazine-2-carboxylic acid

The starting 5-chloropyrazine-2-carboxylic acid (317 mg, 2 mmol) was converted to5-aminopyrazine-2-carboxylic acid (1) by substitution reaction with 25% (m/m) aqueous solutionof ammonia (3 mL). The reaction was carried out 10 mL microwave pressurized vials with stirring(reaction temperature: 100 C, reaction time: 30 min, power output: 80 W). The reaction was repeated20 times to yield reasonable quantity of the starting acid. Once the reaction was completed, the vials content was put onto Petri dish and heated above a water bath with intermittent stirring until a drysolid was obtained (ammonium salt of the product). To get the free acid form, the ammonium salt wasdissolved in water and drop-wise acidified with 10% hydrochloric acid to reach pH of 4. The mixturewas then left to cool down in room temperature for 5 min then kept in the fridge for 15 min. The formedfree acid crystals were filtered off by filtration paper with suction and left to dry overnight. After itwas dried, the resulting 5-aminopyrazine-2-carboxylic acid (1) was esterified in several microwavepressurized vials; 3 mL of anhydrous propanol and 2 drops of concentrated sulfuric acid were added to278 mg (2 mmol) of compound 1 in each vial. The esterification was carried out in microwave reactor(reaction temperature: 100 C, reaction time: 1 h, power output: 80 W). The completion of reaction wasmonitored by TLC in system hexane/ethyl acetate (EtOAc) (1:3). The ester was then purified by flashchromatography using gradient elution 40 to 100% EtOAc in hexane.

The synthetic route of 5-Aminopyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bouz, Ghada; Juhas, Martin; Niklova, Pavlina; Jand?ourek, Ond?ej; Paterova, Pavla; Ek, Ji?i Janou; T?mova, Lenka; Kovalikova, Zuzana; Kastner, Petr; Dole al, Martin; Zitko, Jan; Molecules; vol. 22; 10; (2017);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40155-43-9, name is 5-Aminopyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., category: Pyrazines

5-aminopyrazine-2-carboxylic acid (493 mg, 3.54 mmol; Ark Pharm, Inc., Libertyville, IL) was stirred in dry Lambda/,Lambda/-dimethylformamide (3.0 mL) at room temperature under nitrogen. Solid potassium carbonate (742 mg, 5.37 mmol) was added, followed by benzyl bromide (0.43 mL, 3.6 mmol). The mixture was stirred for 22 hours and then diluted with ethyl acetate and water. The layers were separated, and the aqueous layer was extracted with ethyl acetate. The combined organics were washed with brine, dried over sodium sulfate, filtered, and evaporated. The residue was purified by silica chromatography using a 4Og pre-packed column, eluting with ethyl acetate. The product fractions were combined, evaporated, and dried under high vacuum to afford (I- 22a) (161 .2 mg, 0.70 mmol, 20%): m/z 229.9 (M+H)+.

The synthetic route of 40155-43-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; BENBOW, John William; LOU, Jihong; PFEFFERKORN, Jeffrey Allen; TU, Meihua Mike; WO2010/29461; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem