Category: 39204-49-4

Schafer, Gabriel published the artcileScalable Synthesis of Trifluoromethylated Imidazo-Fused N-Heterocycles Using TFAA and Trifluoroacetamide as CF3-Reagents, Computed Properties of 39204-49-4, the main research area is heterocyclic benzylamine trifluoroacetic anhydride dehydrative cyclization; trifluoromethylated imidazo fused nitrogen heterocycle preparation.

A scalable synthesis of trifluoromethylated imidazo-fused N-heterocycles, e.g. I, from heterocyclic benzylamines using TFAA as trifluoromethylating reagent is presented. The reaction proceeds via intermediate benzylic N-trifluoroacetamides followed by dehydrative cyclization to the products. To further broaden the scope and practicality, a new method for the preparation of benzylic N-trifluoroacetamides via alkylation of trifluoroacetamide with benzyl (pseudo)halides was developed. Both methods proceed under mild conditions, and their symbiosis provides access to a wide range of novel CF3-heterocycles.

Organic Letters published new progress about Cyclization. 39204-49-4 belongs to class pyrazines, name is Pyrazin-2-ylmethanamine hydrochloride, and the molecular formula is C5H8ClN3, Computed Properties of 39204-49-4.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Ding, Yun published the artcileDevelopment and Synthesis of DNA-Encoded Benzimidazole Library, Formula: C5H8ClN3, the main research area is preparation DNA conjugated benzimidazole library NK3 receptor antagonist; DNA tagged fluoronitrobenzamide amine aldehyde; DNA-encoded library technology; benzimidazole.

Encoded library technol. (ELT) is an effective approach to the discovery of novel small-mol. ligands for biol. targets. A key factor for the success of the technol. is the chem. diversity of the libraries. Here we report the development of DNA-conjugated benzimidazoles. Using 4-fluoro-3-nitrobenzoic acid as a key synthon, we synthesized a 320 million-member DNA-encoded benzimidazole library using Fmoc-protected amino acids, amines and aldehydes as diversity elements. Affinity selection of the library led to the discovery of a novel, potent and specific antagonist of the NK3 receptor.

ACS Combinatorial Science published new progress about Chemical library. 39204-49-4 belongs to class pyrazines, name is Pyrazin-2-ylmethanamine hydrochloride, and the molecular formula is C5H8ClN3, Formula: C5H8ClN3.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Ma, Zhuang published the artcileStable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines, Product Details of C5H8ClN3, the main research area is aryl nitrile nickel nanocatalyst selective hydrogenation; aromatic primary amine preparation; recyclable silica support nickel catalyst preparation.

Silica supported ultrasmall Ni-nanoparticles allow for general and selective hydrogenation of all kinds of nitriles to primary amines under mild conditions. By calcination of a template material generated from Ni(II)nitrate and colloidal silica under air and subsequent reduction in the presence of mol. hydrogen the optimal catalyst was prepared The prepared supported nanoparticles are stable, was conveniently used and easily recycled. The applicability of the optimal catalyst material was shown by hydrogenation of >110 diverse aliphatic and aromatic nitriles including functionalized and industrially relevant substrates. Challenging heterocyclic nitriles, specifically cyanopyridines, provided the corresponding primary amines in good to excellent yields. The resulting amines serve as important precursors and intermediates for the preparation of numerous life science products and polymers.

Chemical Science published new progress about Aliphatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 39204-49-4 belongs to class pyrazines, name is Pyrazin-2-ylmethanamine hydrochloride, and the molecular formula is C5H8ClN3, Product Details of C5H8ClN3.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem