Category: 36070-80-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 36070-80-1

To a suspension of 5-chloropyrazine-2-carboxylic acid (1.00 g, 631 mmol) in dichloromethane (12 mL) and DMF (0.015 mL) at rt was added oxalyl chloride (0.804 mL, 7.25 mmol) drop wise over 10 min. The mixture was stirred at rt for 2 h before it was concentrated under vacuum to dryness. Tire residue was dissolved in dichloromethan (15 mL). Dimethylamine in THF (3.94 mL, 7.88 mmol) was added at rt over 10 min, followed by triethylamine (1.934 mL, 13.88 mmol). The mixture was stirred at rt for 2 h. The mixture was diluted with ethyl acetate (50 mL) and filtered through Cehte. The filtrate was concentrated under vacuum to dryness, and the residue was applied to flash chromatograph (80 g silica gel, solid loading, 65-100% ethyl acetate) to provide the desired product, 5-chloro-N,N-dimethylpyrazine-2-carboxamide (1.07 g, 5.76 mmol, 91 % yield), as a white solid. LCMS m z 186.1 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; XIAO, Zili; YANG, Michael G.; LIU, Chunjian C.; SHERWOOD, Trevor C.; GILMORE, John L.; WEINSTEIN, David S.; (152 pag.)WO2019/183186; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 36070-80-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

5-chloropyrazine-2-carboxylic acid (15.0g) and ethyl acetate (200 ml) solution which is prepared by mixing, is reacted with a thionyl chloride (30 ml) and N,N-dimethylformamide (0.28 ml), was stirred at 55 C to 60 C for 1 hour. Concentrated within a pressure reduced to reaction mixture, by the addition of toluene concentrating operation was performed 2 times. 4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine (19.96g) and cyclopentylmethyl ether (200 ml) were mixed, to this mixture the residue obtained above in cyclopentylmethyl ether (40 ml) was added dropwise at 10 C or lower, and the reaction mixture was warmed to room temperature and stirred for 5 hours. And round the leucorrhea reaction mixture, water (600 ml) for 15 C hereinafter in the dropped at room temperature the laststraw stirring section. Taking out a solid filtering, drying the adhesive after cleaning the front and back methyl ethyl ketone 5-chloro-N-{4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}pyrazine-2-carboxamide (29g) obtained as solid.

The synthetic route of 5-Chloropyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Co. Ltd.; Takahashi, Daisuke; Maeda, Jun; Inakaki, Yusuke; Nekoro, Genji; Tanaka, Hiroaki; Yokoyama, Katsuhiro; Takamitsu, Hajime; Koike, Takanori; Tsukamoto, Itsei; (153 pag.)KR2015/120516; (2015); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 36070-80-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

In a 2L stainless steel autoclave,Add 317 g (2.0 mol) of 5-chloropyrazine-2-carboxylic acid, cooling to 0 ~ 10 C, adding anhydrous hydrogen fluoride 480g (24mol),The temperature was further lowered to -40 C, and sulfur tetrafluoride 476 (4.4 mol) was introduced.Then, the temperature was slowly raised to 75 to 80 C, and the reaction was kept for 6 hours.At the end of the reaction, the reaction hydraulic pressure is poured into the ice water.Neutralize to pH=7 with 10% aqueous sodium carbonate solution.The organic layer is separated and steamed,The obtained product was subjected to rectification to obtain 329 g of 2-chloro-5-trifluoromethylpyrazine in an amount of 99%.The yield was 90%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jinkai (Liaoning) Chemical Co., Ltd.; Li Degang; Wang Yongcan; Fu Limin; Tang Xiaofeng; Qi Yue; Sun Jie; Yang Yang; Zhang Wei; (6 pag.)CN107840828; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C5H3ClN2O2

5-Chloropyrazine-2-carboxylic acid [CAS RN: 36070-80-1] (420 mg, 2.65 mmol,1.0 eq) was dissolved in 10 mL THF, and CDI (430 mg, 2.65 mmol, 1.0 eq) was added. Then, the reaction mixture was heated to 75C for 45 mm. On cooling the resulting solution was added dropwise to a solution of tert-butyl methyl[2- (methylamino)ethyl]carbamate [CAS-RN: 112257-19-9] (513 mg, 2.73 mmol,1.03 eq) in 3 mL THF. The reaction mixture was stirred at 70C for 60 mm. Thevolatile components were removed in vacuo and the crude material was purified via preparative MPLC (Biotage Isolera; 25 g SNAP cartridge: hexane -> hexane/ethyl acetate 2/1 -> hexane/ethyl acetate 2/3) to give 322 mg (37% yield of theory) of the title compound.UPLC-MS (Method 1): R = 1 .07 mm; MS (EI0): m/z = 329 [M+H].

According to the analysis of related databases, 36070-80-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SIEMEISTER, Gerhard; HEINRICH, Tobias; PRECHTL, Stefan; STOeCKIGT, Detlef; ROTTMANN, Antje; WO2015/113927; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., SDS of cas: 36070-80-1

To a solution of 5-chloropyrazine-2-carboxylic acid (300 mg, 1.89 mmol) in CH2C12 (3.8 mL) was added EDCI (401 mg, 2.09 mmol), DMAP (12.5 mg, 0.102 mmol) and MeOH (0.15 mL, 3.7 mmol) at room temperature. After stirring for 2 h, the reaction was quenched by adding saturated NH4C1 solution. The crude products were extracted with CH2C12 (x3), and the combined organic extracts were washed with brine, dried (MgS04), and concentrated in vacuo. The residue was purified by flash column chromatography (hexane/EtOAc = 9/1 to 7/1) to afford methyl 5-chloropyrazine-2-carboxylate (213 g, 65%) as a white solid. NMR (300 MHz, CDCh) delta 9.12 (d, J = 1.8 Hz, 1H), 8.73 (d, J = 1.8 Hz, 1H), 4.07 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; UNIVERSITY OF HAWAII; TURKSON, James; YUE, Peibin; TIUS, Marcus; BROTHERTON-PLEISS, Christine; LOPEZ TAPIA, Francisco, Javier; (420 pag.)WO2018/136935; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 36070-80-1

5-chloropyrazine-2-carboxylic acid (1.00 g, 6.31 mmol),2,2,2-Trifluoroethylamine (687.52 mg, 6.94 mmol),N, N-diisopropylethylamine (3.56 mL, 20.81 mmol),Dissolve O- (7-azabenzotriazol-1-yl) -N, N, N ‘, N’-tetramethyluronium hexafluorophosphate in methylene chloride (30 mL) and stir at room temperature overnight under a nitrogen atmosphere did.Thereafter, saturated aqueous sodium bicarbonate solution was added, extraction was performed with ethyl acetate, and magnesium sulfate was added for dehydration.The magnesium sulfide was removed by suction filtration, the solution was concentrated under reduced pressure, and the composition was purified by silica gel chromatography to give the title compound.(1.10 g, 72.8% yield, white solid)

The synthetic route of 36070-80-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nippon Kayaku Co.,Ltd.; Hasegawa, Shinji; Ueno, Shotaro; Shinko, Daiki; Kobayashi, Takehiko; Miyake, Takaaki; Asano, Shu; Sumi, Takuto; (101 pag.)JP2019/19124; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 36070-80-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 36070-80-1 name is 5-Chloropyrazine-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The 5-cyclopropylmethoxy-pyrazine-2-carboxylic acid was obtained following the general procedure below:A solution of 5-chloro-pyrazine-2-carboxylic acid (1.50 g, 9.46 mmol) in dry dimethylsulfoxide (5 ml) was treated at 25 C. with cyclopropyl-methanol (1.02 g, 14.1 mmol) and powdered potassium hydroxide (2.12 g, 37.4 mmol). The mixture was heated in a microwave oven at 80 C. for 90 minutes. For the workup, the reaction mixture was quenched with an aqueous solution of citric acid (10%), then extracted with ethyl acetate (5×30 ml), followed by the extraction with a 4:1-mixture of dichloromethane and methanol. The combined organic layers were washed with brine (200 ml), dried and evaporated ate reduced pressure. After lyophilization the 5-cyclopropylmethoxy-pyrazine-2-carboxylic acid (34% yield) was obtained as a white solid. MS (ISP): m/z=195.0 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloropyrazine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Hilpert, Hans; Wostl, Wolfgang; US2012/258962; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 36070-80-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

5-(2,2-difluoroethoxy)pyrazine-2-carboxylic acid Potassium tert-butoxide (4.25 g, 37.84 mmol) is added to a solution of 5-chloropyrazine-2-carboxylic acid (1.00 g, 6.31 mmol) and difluoroethanol (2.59 g, 31.54 mmol) in DMF (20 mL) and the mixture is heated at 100 C. for 2 hours. The reaction is cooled to room temperature and stirred overnight under nitrogen. The reaction is quenched with 1M HCl (30 mL) and extracted with ethyl acetate (3 times). The combined organic layers are dried over sodium sulfate, filtered, and concentrated to give the crude product. The crude product is purified by silica gel flash chromatography, eluting with a gradient of 0.5% to 10% methanol in dichloromethane and azeotroped with xylenes to remove residual DMF to give the title product (1.18 g, 91%). ES/MS (m/e): 205.0 (M+1). The following compounds in Table 1 are prepared in a manner essentially analogous to the method set forth in Preparation 21 using the appropriate alcohol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GREEN, Steven James; HEMBRE, Erik James; MERGOTT, Dustin James; SHI, Yuan; WATSON, Brian Morgan; WINNEROSKI, JR., Leonard Larry; US2014/371212; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 5-Chloropyrazine-2-carboxylic acid

A mixture of 5-chloropyrazine-2-carboxylic acid (1.53 g, 9.66 mmol) in acetonitrile (15 mL, 283 mmol) is treated with DMF (115 muL, 1.49 mmol) and oxalyl chloride (970 muL, 11.1 mmol). The mixture is stirred at ambient temperature under nitrogen for 20 minutes

The synthetic route of 36070-80-1 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, molecular formula is C5H3ClN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Chloropyrazine-2-carboxylic acid

N,N-Diisopropylethylamine (1.3 mL, 7.5 mmol) was added to a mixture of 5-chloropyrazine-2-carboxylic acid (0.40 g, 2.5 mmol), N,N,N?,N?-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (1.0 g, 2.8 mmol) and (2S)-1,1,1-trifluoropropan-2-amine (0.28 g, 2.5 mmol) in methylene chloride (10 mL). The reaction mixture was stirred at room temperature overnight. The reaction mixture was worked up with sat. aqueous NaHCO3, and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-15%) to afford the desired product (0.47 g, 73%). LCMS cacld. for C8H8ClF3N3O (M+1)+: m/z=254.0. Found: 253.9.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 36070-80-1, its application will become more common.