Category: 356783-16-9

These common heterocyclic compound, 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3,6-Dichloropyrazine-2-carbonitrile

REFERENTIAL EXAMPLE II-15 In 50 mL of N,N-dimethylformamide was dissolved 10.0 g of 3,6-dichloro-2-pyrazinecarbonitrile. After adding 6.49 mL of thiophenol and 11.91 g of potassium carbonate successively, the mixture thus obtained was stirred at 40 C. for 3 hours. The reaction mixture was poured into a mixture of 100 mL of ethyl acetate and 100 mL of water, and pH was adjusted to 2 with 6 mol/L hydrochloric acid. The organic layer was separated, washed successively with water and saturated aqueous solution of sodium chloride, and dried on anhydrous magnesium sulfate, and then the solvent was removed under reduced pressure. The residue thus obtained was purified by silica gel column chromatography [eluent: toluene:n-hexane=1:3] to obtain 3.80 g of 6-chloro-3-(phenylsulfanyl)-2-pyrazinecarbonitrile as a light yellow-colored oily product. R (neat) cm-1: 2238 H-NMR (CDCl3) delta: 7.00-7.70(5H,m), 8.39(1H,s)

The synthetic route of 3,6-Dichloropyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 356783-16-9, Formula: C5HCl2N3

KF (1 g, 6 eq) and TBAB (372.3 mg, 0.4 eq) were dissolved in a mixed solvent of toluene (10 ml) and dimethylsulfoxide (5 ml)After azeotropic removal of water,Compound 6 (500 mg, 1 eq) was added,55 ‘C conditions,Stir for 3 h.TLC shows the raw material reaction is complete,After falling to room temperature,30% H2O2 (0.35 ml) was added under ice bath,Reaction at 27 C for 2 h, add water (1 ml) andNaHCO3 (0.132 g, 1.57 mmol),50 reaction 8.5h,Ice bath with 6N HCl,Adjust pH = 1.0,Ethyl acetate (4 x 5 ml)The organic layer was washed twice with saturated brine,Dried over anhydrous sodium sulfate,The organic solvent was distilled off,Recrystallization from 20 times ethanol (crude weight ratio of ethanol to 1: 5 to 30)Obtained as white solid 7 (favipiravir),The yield was 65% (from the reactants6 is calculated).mp: 175-177 C.

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Reference of 356783-16-9, The chemical industry reduces the impact on the environment during synthesis 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, I believe this compound will play a more active role in future production and life.

3.48 g of 3,6-dichloro-2-cyanopyrazine (3) was mixed with 10 mL of dry dimethylsulfoxide,Dry potassium fluoride 5.23g and tetrabutylammonium bromide 2.15g mixed evenly, sealed heating,Control reaction temperature 55 , stirring reaction 3h, the reaction is completed and rushed into 10mL cold water,Extracted three times with ethyl acetate (20 mL * 3)The organic phases were combined, washed twice with saturated brine,The organic phase was dried over anhydrous sodium sulfate and filtered,To a solution of 1.49 g of pale yellow solid 3, 6-difluoro-2-cyanopyrazine (4)Yield 52.80%, m.p. 56-57 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,6-Dichloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhengzhou University; Li Mengyang; (6 pag.)CN107226794; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

356783-16-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

REFERENTIAL EXAMPLE II-11 In 15 ml of dimethylformamide was dissolved 1.5 g of 3,6-dichloro-2-pyrazinecarbonitrile. After adding 1.2 g of 4-methoxyphenol and 1.8 g of potassium carbonate, the mixture thus obtained was stirred at room temperature for 30 minutes. A mixture of 20 mL of ethyl acetate and 60 mL of water was added to the reaction mixture, and the organic layer was separated. The organic layer was washed successively with water and saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue thus obtained was purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=5:1] to obtain 2.1 g of 6-chloro-3-(4-methoxyphenoxy)-2-pyrazinecarbonitrile as a yellow-colored solid product. R (KBr) cm-1: 2236 H-NMR (CDCl3) delta: 3.83(3H,s), 6.95(2H,d,J=9.2 Hz), 7.11(2H,d,J=9.2 Hz), 8.26(1H,s)

The synthetic route of 356783-16-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 356783-16-9

A mixture of 8 (2.6 g, 15.0 mmol), KF (5.23 g, 90.0 mmol), tetrabutylammonium bromide (1.93 g, 6.0 mmol) was predried under vacuum over phosphorus pentoxide. The mixture was charged in a polytetrafluoroethylene bottle followedby the addition of dried DMSO (20 mL), and heated at 60 C for 2.5-3 h. The reaction mixture was cooled to room temperature, treated with water (80 mL) and extracted with diethyl ether (100 mL). The organic layer was washed with water (3 ¡Á 25 mL), dried over Na2SO4, and purified by chromatography on silica gel with PE/EA (50:1-10:1) as eluent to give 9 as a white solid (1.27 g, yield 60%). 3,6-Difluoropyrazine-2-carbonitrile (9) Yield: 60%. white solid, M.p.: 58-60 C (Lit. 56-57 C, Li 2017). 1H NMR (400 MHz, CDCl3)delta 8.35 (dd, J = 8.1,1.4 Hz, 1H). 13C NMR (125 MHz, CDCl3):delta 159.73-157.69(d, J = 255 Hz), 157.64-155.62 (d, J = 252.5 Hz), 135.09 (dd, J = 41.6, 11.0 Hz), 114.04 (d, J = 35.8 Hz), 110.62 (d,J = 9.1 Hz). EI-MS m/z: 141 (M+, 100), 122 (M+, -F, 50),96 (M+, -F, -CN, 50).

Statistics shows that 356783-16-9 is playing an increasingly important role. we look forward to future research findings about 3,6-Dichloropyrazine-2-carbonitrile.

Reference:
Article; Guo, Qi; Xu, Mingshuo; Guo, Shuang; Zhu, Fuqiang; Xie, Yuanchao; Shen, Jingshan; Chemical Papers; vol. 73; 5; (2019); p. 1043 – 1051;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem