Category: 356783-16-9

Adding a certain compound to certain chemical reactions, such as: 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 356783-16-9, Safety of 3,6-Dichloropyrazine-2-carbonitrile

KF (1 g, 6 eq) and TBAB (372.3 mg, 0.4 eq) were dissolved in a mixed solvent of toluene (10 ml) and dimethylsulfoxide (5 ml)After azeotropic removal of water,Compound 6 (500 mg, 1 eq) was added,55 ‘C conditions,Stir for 3 h.TLC shows the raw material reaction is complete,After falling to room temperature,30% H2O2 (0.35 ml) was added under ice bath,Reaction at 27 C for 2 h, add water (1 ml) andNaHCO3 (0.132 g, 1.57 mmol),50 reaction 8.5h,Ice bath with 6N HCl,Adjust pH = 1.0,Ethyl acetate (4 x 5 ml)The organic layer was washed twice with saturated brine,Dried over anhydrous sodium sulfate,The organic solvent was distilled off,Recrystallization from 20 times ethanol (crude weight ratio of ethanol to 1: 5 to 30)Obtained as white solid 7 (favipiravir),The yield was 65% (from the reactants6 is calculated).mp: 175-177 C.

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Reference:
Patent; Central South University; Liu Fengliang; Li Cuiqin; (19 pag.)CN106866553; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 356783-16-9, The chemical industry reduces the impact on the environment during synthesis 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, I believe this compound will play a more active role in future production and life.

To a solution of 3,6-dichloropyrazine-2-carbonitrile (1.088 g, 6.25 mmol) in toluene (12 mL) at 0 C. was added dropwise methyl hydrazine (362 muL, 6.88 mmol). Reaction mixture was stirred for 3 hours at 0 C. LCMS shows no starting material. Reaction mixture was concentrated and purified by CombiFlash (120 g Gold, 10-45% EtOAc/Hex) to give impure product. Crystallized from hot acetone/hexane to give two crops of 5-chloro-1-methyl-1H-pyrazolo[3,4-b]pyrazin-3-amine. LCMS-ESI+: calc’d for C6H7ClN5: 184.0 (M+H)+; found: 184.2 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,6-Dichloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Gilead Sciences, Inc.; Cai, Zhenhong R.; Guo, Hongyan; Ji, Mingzhe; Jin, Haolun; Lee, Amy; McFadden, Ryan; Mitchell, Michael L.; Munoz, Manuel; Pyun, Hyung-Jung; Xu, Lianhong; Yang, Hong; (272 pag.)US2018/118734; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

356783-16-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

REFERENTIAL EXAMPLE II-11 In 15 ml of dimethylformamide was dissolved 1.5 g of 3,6-dichloro-2-pyrazinecarbonitrile. After adding 1.2 g of 4-methoxyphenol and 1.8 g of potassium carbonate, the mixture thus obtained was stirred at room temperature for 30 minutes. A mixture of 20 mL of ethyl acetate and 60 mL of water was added to the reaction mixture, and the organic layer was separated. The organic layer was washed successively with water and saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue thus obtained was purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=5:1] to obtain 2.1 g of 6-chloro-3-(4-methoxyphenoxy)-2-pyrazinecarbonitrile as a yellow-colored solid product. R (KBr) cm-1: 2236 H-NMR (CDCl3) delta: 3.83(3H,s), 6.95(2H,d,J=9.2 Hz), 7.11(2H,d,J=9.2 Hz), 8.26(1H,s)

The synthetic route of 356783-16-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 356783-16-9, These common heterocyclic compound, 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

REFERENTIAL EXAMPLE II-12 In 25 mL of dimethylformamide was dissolved 2.5 g of 3,6-dichloro-2-pyrazinecarbonitrile. After adding 3.2 g of 4-(benzyloxy)phenol and 3.0 g of potassium carbonate, the mixture was stirred at room temperature for one hour. A mixture of 25 ml of ethyl acetate and 100 mL of water was added to the reaction mixture, and the organic layer was separated. The organic layer thus obtained was washed successively with water and saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. Diisopropyl ether was added to the residue, the insoluble matter was filtered off, and the filtrate was concentrated. The residue thus obtained was washed with n-hexane to obtain 3.84 g of 3-[(4-(benzyloxy)phenoxy)]-6-chloro-2-pyrazinecarbonitrile as a light brown-colored solid product. R (KBr) cm-1: 2238 H-NMR (CDCl3) delta: 5.12(2H,s), 7.03-7.48(9H,m), 8.65(1H,s)

Statistics shows that 3,6-Dichloropyrazine-2-carbonitrile is playing an increasingly important role. we look forward to future research findings about 356783-16-9.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 356783-16-9, A common heterocyclic compound, 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, molecular formula is C5HCl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE II-29 In 60 mL of dimethyl sulfoxide was dissolved 3.0 g of 3,6-dichloro-2-pyrazinecarbonitrile. After adding 3.0 g of potassium fluoride, the mixture thus obtained was stirred at 90-100 C. for 2 hours. The reaction mixture was returned to room temperature, to which were successively added 2.1 g of 2-methyl-1,3-cyclopentandione and 7.2 ml of triethylamine. The mixture thus obtained was stirred at room temperature for one hour. The reaction mixture was added to a mixture of 50 mL of ethyl acetate and 200 mL of water, and the organic layer was separated. The organic layer thus obtained was washed successively with water and saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue thus obtained was purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=2:1] to obtain 1.7 g of 6-fluoro-3-[(2-methyl-3-oxo-1-cyclopenten-1-yl)oxy]-2pyrazinecarbonitrile as a yellow-colored solid product. IR (KBr) cm-1: 2238, 1707, 1676 1H-NMR (CDCl3) delta: 1.72(3H,t,J=1.8 Hz), 2.58-2.68(2H,m), 2.76-2.91(2H,m), 8.29(1H,d,J=8.1 Hz)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3,6-Dichloropyrazine-2-carbonitrile

KF2H2O (1.3 g, 6 eq) and TBAB (tetrabutylammoniumbromide) (0.3 g, 0.4 eq) were added into the mixed solventcontaining 4 mL of DMSO and 8 mL of toluene. Thetoluene was subsequently removed by distillation underreduced pressure. A further 8 mL of toluene was thenadded and once again removed by distillation underreduced pressure with the purpose of removing the moisture of the reagent relating to the reaction. Then, 3,6-dichloropyrazine-2-carbonitrile (0.4 g, 1 eq) was addedand the mixture was stirred at 50 C for 3 h. Subsequently,anhydrous K2CO3 (0.04 g) and 30% H2O2(0.28 mL) were added into the solution at 0 C stirring for1.5 h at 25 C. Water (1 mL) and NaHCO3 (0.132 g)were added into the 3,6-difluoropyrazine-2-carboxamidewith magnetic stirring for 8 h at 50 C and TLC (MeOH:EA = 1:1, v/v, Rf = 0.72) was used to monitor thereaction. Then, 6 M HCl was added into the solution andthe pH of the solution was adjusted to 1.0. Then, thesolution was extracted with ethyl acetate (5 9 10 mL).The organic phase was washed with brine (3 9 10 mL),dried with anhydrous Na2SO4, and was filtered to removethe drying agent. The ethyl acetate was removed by distillationunder reduced pressure to obtain the crudecompound of 7. Then, the crude 7 was dissolved intoEtOH (6 mL, 95%). The suspension was heated to refluxfor 30 min and was filtered to crystallize. The filtrate wascooled to 25-30 C which was kept for 4 h. The crystal ofpure 6-fluoro-3-hyroxypyrazine-2-carboxamide (7)(0.25 g, 60%) was obtained in open system.

The synthetic route of 356783-16-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Feng-Liang; Li, Cui-Qin; Xiang, Hao-Yue; Feng, Si; Chemical Papers; vol. 71; 11; (2017); p. 2153 – 2158;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5HCl2N3

3.49 g of potassium fluoride and 1.33 g of tetrabutylammonium bromide were suspended in a mixed solvent containing 40 ml of toluene and 20 ml of dimethyl sulfoxide. The toluene was subsequently removed by distillation at normal pressure. A further 40 ml of toluene was then added and once again removed by distillation, thereby removing moisture from the system. 14.08 g of a toluene solution of 3,6-dichloropyrazine-2-carbonitrile with a concentration of 24.7% was then added to the reaction system, and the resulting mixture was stirred at 60 C. for 2.5 hours. Subsequently, 20 ml of toluene and 30 ml of water were added, and a separation was performed. The organic layer was washed with 20 ml of water, 20 ml of water and concentrated hydrochloric acid were then added to the organic layer to adjust the pH to 1.6, and another separation was performed. The organic layer was then washed with 20 ml of a 5% saline solution. Quantitative analysis by HPLC of the obtained organic layer revealed an equivalent yield of pure 3,6-difluoropyrazine-2-carbonitrile of 2.60 g (yield: 92.3%).

The synthetic route of 356783-16-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nippon Soda Co., Ltd.; US2011/275817; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 356783-16-9, The chemical industry reduces the impact on the environment during synthesis 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, I believe this compound will play a more active role in future production and life.

To a solution of 3,6-dichloropyrazine-2-carbonitrile (1.088 g, 6.25 mmol) in toluene (12 mL) at 0 C. was added dropwise methyl hydrazine (362 muL, 6.88 mmol). Reaction mixture was stirred for 3 hours at 0 C. LCMS shows no starting material. Reaction mixture was concentrated and purified by CombiFlash (120 g Gold, 10-45% EtOAc/Hex) to give impure product. Crystallized from hot acetone/hexane to give two crops of 5-chloro-1-methyl-1H-pyrazolo[3,4-b]pyrazin-3-amine. LCMS-ESI+: calc’d for C6H7ClN5: 184.0 (M+H)+; found: 184.2 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,6-Dichloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Gilead Sciences, Inc.; Cai, Zhenhong R.; Guo, Hongyan; Ji, Mingzhe; Jin, Haolun; Lee, Amy; McFadden, Ryan; Mitchell, Michael L.; Munoz, Manuel; Pyun, Hyung-Jung; Xu, Lianhong; Yang, Hong; (272 pag.)US2018/118734; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 356783-16-9, These common heterocyclic compound, 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

REFERENTIAL EXAMPLE II-12 In 25 mL of dimethylformamide was dissolved 2.5 g of 3,6-dichloro-2-pyrazinecarbonitrile. After adding 3.2 g of 4-(benzyloxy)phenol and 3.0 g of potassium carbonate, the mixture was stirred at room temperature for one hour. A mixture of 25 ml of ethyl acetate and 100 mL of water was added to the reaction mixture, and the organic layer was separated. The organic layer thus obtained was washed successively with water and saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. Diisopropyl ether was added to the residue, the insoluble matter was filtered off, and the filtrate was concentrated. The residue thus obtained was washed with n-hexane to obtain 3.84 g of 3-[(4-(benzyloxy)phenoxy)]-6-chloro-2-pyrazinecarbonitrile as a light brown-colored solid product. R (KBr) cm-1: 2238 H-NMR (CDCl3) delta: 5.12(2H,s), 7.03-7.48(9H,m), 8.65(1H,s)

Statistics shows that 3,6-Dichloropyrazine-2-carbonitrile is playing an increasingly important role. we look forward to future research findings about 356783-16-9.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 356783-16-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

(a) In 1.1 L of dimethyl sulfoxide was suspended 90.1 g of 3,6-dichloro-2-pyrazinecarbonitrile. After adding 180.5 g of potassium fluoride and 66.8 g of tetra-n-butylammonium bromide, the mixture was stirred at 50-55 C. for 6 hours. The reaction mixture was returned to room temperature and added to a mixture of 1.1 L of ethyl acetate and 2.2 L of water, and the organic layer was separated. Water (1 L) was added to the organic layer, pH was adjusted to 2.5 with 1 mol/L hydrochloric acid, and the organic layer was separated. The organic layer was washed with saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue was purified by silica gel chromatography [eluent: n-hexane:ethyl acetate=10:1] to obtain 58.3 g of 3,6-difluoro-2-pyrazinecarbonitrile as a colorless solid product. R (KBr) cm-1: 2250 H-NMR (CDCl3) delta: 8.34(1H,dd,J=1.3, 7.9 Hz)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,6-Dichloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem