Category: 33332-30-8

Related Products of 33332-30-8,Some common heterocyclic compound, 33332-30-8, name is 2-Chloro-6-methoxypyrazine, molecular formula is C5H5ClN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 137 A mixture of 2-chloro-6-methoxypyrazine (500 mg, 3.46 mmol, 1.0 eq), bis(pinacolato)diboron (1.05 g, 4.13 mmol, 1.2 eq), Pd2(dba)3 (95 mg, 0.1 mmol, 0.029 eq), P(Cy)3 (120 mg, 0.43 mmol, 0.13 eq), and potassium acetate (600 mg, 6.11 mmol, 1.77 eq) in 1,2-dimethoxyethane (10 mL) was irradiated under argon at 150 C. in a microwave oven for 3 h. The mixture was allowed to cool to RT, quenched with water and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4 and filtered. The filtrate was concentrated in vacuo to afford the pinacol ester (600 mg).

The synthetic route of 33332-30-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INTELLKINE, LLC; INFINITY PHARMACEUTICALS, INC.; CASTRO, Alfredo C.; EVANS, Catherine A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel A.; TREMBLAY, Martin R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; US2013/53362; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 33332-30-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33332-30-8, name is 2-Chloro-6-methoxypyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 2-chloro-6-methoxypyrazine (0.50 g, 3.46 mmol), bis(pinacolato)diboron (0.966 g, 3.80 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.095 g, 0.10 mmol), tricyclohexyl phosphine (0.116 g, 0.42 mmol) and potassium acetate (0.509 g, 5.19 mmol) in 1,2-dimethoxyethane (10 mL) was run for 3 h at 150 C. in a microwave oven under argon atmosphere. The reaction mixture was partitioned between water and diethyl ether and the organic phases were pooled, dried over magnesium sulfate, filtered and concentrated to give 1.15 g (quantative yield) of the crude title compound which was used in the next reaction step without further purification. MS (CI) m/z 237.

The synthetic route of 2-Chloro-6-methoxypyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AstraZeneca AB; Astex Therapeutics Ltd.; US2007/299087; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 33332-30-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33332-30-8 as follows.

Example 90 2-Methoxy-6-(‘4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl’)pyrazine-; A mixture of 2-chloro-6-methoxypyrazine (0.50 g, 3.46 mmol), bis(pinacolato)diboron (0.966 g, 3.80 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.095 g, 0.10 mmol), tricyclohexyl phosphine (0.116 g, 0.42 mmol) and potassium acetate (0.509 g, 5.19 mmol) in 1,2-dimethoxy ethane (10 mL) was run for 3h at 15O0C in a microwave oven under argon atmosphere. The reaction mixture was partitioned between water and diethyl ether and the organic phases were pooled, dried over magnesium sulfate, filtered and concentrated to give 1.15 g (quantative yield) of the crude title compound which was used in the next reaction step without further purification; MS (CI) m/z 237.

According to the analysis of related databases, 33332-30-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTEX THERAPEUTICS LTD; WO2007/145571; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 33332-30-8, name is 2-Chloro-6-methoxypyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33332-30-8, Recommanded Product: 2-Chloro-6-methoxypyrazine

To a solution of 0.49 g (0.0034 mol) of 2-chloro-6-methoxy-pyrazine (Example P7) in 9 mi of dichloromethane there are added, under an argon gas atmosphere, first, within a period of 45 minutes and at 20C, 0.19 g (0.002 mol) of hydrogen peroxide-urea adduct and then, dropwise, 0.3 ml (0.0021 mol) of trifluoroacetic anhydride in dichloromethane. Then there are again added, within a period of 45 minutes and at 20C, 0. 19 g (0.002 mol) of hydrogen peroxide-urea adduct and 0.3 ml (0.0021 mol) of trifluoroacetic anhydride in dichloro- methane, and the reaction mixture is stirred further at 20C for 30 minutes. The reaction is stopped by adding water, and the aqueous phase obtained is extracted with chloroform. The combined organic phases are washed with 5 % sodium hydrogen carbonate solution and saturated sodium chloride solution and dried over sodium sulfate. The desired title compound, having a melting point of 121-123C, is obtained in a yield of 0.53 g (98 % of theory). The compound can be used directly for the next reaction step. ‘H NMR (300 MHz, CDC13) : 7.802 ppm (d (J=1.2 Hz), 1 H) ; 7.691 ppm (d (J=1.2 Hz), 1 H) ; 4.012 ppm (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-6-methoxypyrazine, other downstream synthetic routes, hurry up and to see.