Category: 32974-92-8

Related Products of 32974-92-8, The chemical industry reduces the impact on the environment during synthesis 32974-92-8, name is 1-(3-Ethylpyrazin-2-yl)ethanone, I believe this compound will play a more active role in future production and life.

(1) 10 mmol of 2-acetyl-3-ethylpyrazine was dissolved in 20 ml of methanol,Stirring at 60 C for 15 min to prepare a solution;(2) taking 10 mmol of thiosemicarbazide dissolved in 20 ml of methanol,Then, the solution prepared in the step (1) is dropped into a methanol solution containing thiosemicarbazide,The reaction was stirred under reflux at 60 C for 24 h to give a pale yellow precipitate.After the reaction, the mixture was cooled to room temperature, poured into a beaker and evaporated, and the resulting precipitate was filtered.Washed 3 times with absolute ethanol, after drying, the ligand L1;Yield: 79.6%,

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(3-Ethylpyrazin-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangxi Normal University; Yang Feng; Cai Meiling; Li Wenjuan; Liang Hong; (15 pag.)CN109796497; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 32974-92-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 32974-92-8, name is 1-(3-Ethylpyrazin-2-yl)ethanone belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

(1) 2-acetyl-3-ethylpyrazine (420 ul, 3 mmol) was dissolved in methanol (20 ml).After dissolution,4-Benzyl-3-thiosemicarbazide (501 mg 3 mmol) was added.well mixed,The mixed solution was refluxed at 65 C for 4 h.filter,The filtrate evaporates at room temperature.There are pale yellow crystals,Filter again,Wash 2-3 times with absolute ethanol,Obtaining a ligand L5;

The synthetic route of 1-(3-Ethylpyrazin-2-yl)ethanone has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangxi Normal University; Yang Feng; Sun Zewen; Zhao Lei; Liang Hong; (16 pag.)CN109796501; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32974-92-8, name is 1-(3-Ethylpyrazin-2-yl)ethanone, A new synthetic method of this compound is introduced below., Computed Properties of C8H10N2O

General procedure: The ligands L1-L4 were synthesized by reflux method. Shown in Scheme 1, 5mM of 2-Acetyl-3-ethylpyrazine and thiosemicarbazides (L1), 5mM of 2-Acetyl-3-ethylpyrazine and 4-methylthiosemicarbazide (L2), 5mM of 2-Acetyl-3-ethylpyrazine and 4-phenylthiosemicarbazide (L3), and 5mM of 2-Acetyl-3-ethylpyrazine and 3-pyrrolethiosemicarbazide (L4) were stirred in CH3OH for 3 h at 65C. The ligands were precipitated and filtered. L1-L4 were characterized by infrared spectroscopy, electrospray ionization mass spectrometry (ESI-MS), 1H NMR, and 13C NMR (Supplementary Figs S4- S31). L1: 2-Acetyl-3-ethylpyrazine-thiosemicarbazides; yield:79.6%. Anal. Calcd (%) for C9H13N5S: C, 48.41; H, 5.87; N, 31.36; S, 16.36. Found: C, 48.32; H, 5.80; N, 31.43; S, 16.40. IR, cm-1: 3430.8 (s, amide), 3234.7 (s, NH), 3158.7 (m, aromatic hydrogen), 1598.16, 1504.69, 1459 (s, aromatic), 1396.96 (m, C=N), 1293.39 (s, thioamide), 1155, 1102.57, 880 (m, C-H), 715 (m, C=S), 596. m/z (ESI): calcd for C9H13N5S, 222.08 [M-H]-. 1H NMR (400MHz, DMSO) delta 10.48 (s, 1H), 8.55 (d, J=2.4Hz, 1H), 8.49 (d, J=2.4Hz, 1H), 8.38 (s, 1H), 7.60 (s, 1H), 3.04 (q, J=7.4Hz, 2H), 2.35 (s, 3H), 1.20 (t, J=7.4Hz, 3H); 13C NMR (100MHz, DMSO) delta 179.42, 156.21, 150.18, 148.02, 142.99, 140.68, 28.00, 15.87, 12.75.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Khan, Muhammad Hamid; Cai, Meiling; Li, Shanhe; Zhang, Zhenlei; Zhang, Juzheng; Wen, Xiaoan; Sun, Hongbin; Liang, Hong; Yang, Feng; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32974-92-8, name is 1-(3-Ethylpyrazin-2-yl)ethanone, A new synthetic method of this compound is introduced below., SDS of cas: 32974-92-8

Example 1872-(N-hydroxyethylbenzyl)aminoethyl-2-(3-ethyl)-pyrazylketone 8657 2-acetyl-3-ethylpyrazine (150 mg), hydroxyethylisopropylamine (149 mg), and paraformaldehyde (40 mg) were reacted in dioxane (0.2 ml) at 130 C. for 2 hours.NMR (CDCl3) 1.3 (m, 3H), 2.6 (m, 4H), 3.2 (m, 4H), 8.6 (s, 1H), 8.7 (s, 1H)TG 90.3 (3 mumol) 73 (10 mumol) 30 (30 mumol)SOCE 0 (10 mumol) 0 (30 mumol) 10 (100 mumol)IICR 20 (10 mumol) 10 (30 mumol) 100 (100 mumol)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Japan Science and Technology Agency; US2012/277423; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem