Application of 32710-14-8, A common heterocyclic compound, 32710-14-8, name is 3-Aminopyrazine-2-carbaldehyde, molecular formula is C5H5N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 77 Pyrido[2,3-b]pyrazine-6,7-dicarboxylic acid, diethyl ester STR163 Diethyl oxalacetate, (4.7 g, 0.025 mol) and piperidine (1.66 g, 1.93 mL) are added to 3-aminopyrazine-2-carboxaldehyde (2.4 g, 0.0195 mol) dissolved in 250 mL of toluene. After the reaction mixture is refluxed for two hours, the toluene is removed under reduced pressure to give a dark red oily residue. The product is purified by column chromatography on silica gel (hexane:EtOAc, 4:1), affording 3.1 g (58% yield), of the crude desired product. Crystallization from ether-hexane (4:1) gives analytically pure compound 1.5 g (28%) having a melting point 83-85 C.
The synthetic route of 32710-14-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; American Cyanamid Company; US5252538; (1993); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem