Category: 32587-10-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32587-10-3, name is 3-Aminopyrazine-2-carboxamide, A new synthetic method of this compound is introduced below., Quality Control of 3-Aminopyrazine-2-carboxamide

To a stirred solution of 3-aminopyrazine-2-carboxamide (1 g, 7.24 mmol, prepared according to International Patent Application Publication No. W0201 1054922) and NaOAc (200mg, 2.44 mmol) in HOAc (15 mE) was added Br2 (0.45 mE) dropwise at 0C for 1 hour, and then it was stirred at 50C for 8 hours. After the mixing, it was poured into ice-water and filtrated, the crude product of 3-amino-6-bromopyrazine-2-carboxamide as brown solid (1.5 g, yield: 95%) was obtained. ?H-NMR (DMSO-d6, 400 MHz) 8.30 (s, 1H), 7.93 (s, 2H), 7.66 (s, 2H). MS (M+H):217/219.

The synthetic route of 32587-10-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/205593; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 32587-10-3, name is 3-Aminopyrazine-2-carboxamide, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32587-10-3, SDS of cas: 32587-10-3

12 g of 3-aminopyrazine-2-carboxamide was added to 150 ml of acetic acid, 19 g of bromoform was slowly added, and the mixture was heated under reflux and stirred for 3 hours. The mixture was concentrated, water and ethyl acetate were added for extraction, concentrated, and the residue was applied to a silica gel column. 10 g of 3-amino-6-bromopyrazine-2-carboxamide was isolated.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Aminopyrazine-2-carboxamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Changsha Shencheng Biological Technology Co., Ltd.; Bu Gonggaofamingren; (5 pag.)CN107513041; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 32587-10-3, name is 3-Aminopyrazine-2-carboxamide, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32587-10-3, Recommanded Product: 32587-10-3

(c) In 9 mL of trifluoroacetic acid was dissolved 0.3 g of 3-amino-2-pyrazinecarboxamide. At an ice-cooled temperature, 10% fluorine gas (a fluorine gas diluted with nitrogen gas) was introduced into the solution at a rate of 45 ml per minute for a period of 22 minutes. After stirring the mixture at an ice-cooled temperature for 17 minutes, the temperature was elevated to room temperature. The reaction mixture was added to a mixture of 30 mL of saturated aqueous solution of sodium hydrogen carbonate and 30 mL of ethyl acetate, and the organic layer was separated. The remaining aqueous layer was acidified with 6 mol/L hydrochloric acid and then extracted with 20 ml of ethyl acetate. The organic layers thus obtained were united, washed successively with 10 mL of water and 10 mL of saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue thus obtained was purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=2:1] to obtain 0.015 g of 3-amino-6-fluoro-2-pyrazinecarboxamide as a light yellow-colored solid product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Aminopyrazine-2-carboxamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 32587-10-3, These common heterocyclic compound, 32587-10-3, name is 3-Aminopyrazine-2-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 3 Synthesis of 3-Aminopyrazine-2-carbonitrile (Intermediate 2) To a solution of intermediate 1 (3.5 g, 25 mmol) in DMF (40 mL) at RT was added POCl3 (4.5 mL, 49 mmol) slowly. The resulting mixture was heated at 80 C. for 15 min and then cooled to RT. The mixture was poured into ice water and the mixture neutralized with 10% NaOH solution. The resulting solid was filtered and redissolved in 5% HCl. The solution was heated at 70 C. for 30 min and the resulting solid filtered. After thoroughly washed with water, the title compound was obtained as a brown solid (1.7 g, 56%). 1H NMR (500 MHz, DMSO-d6): delta 8.28 (d, J=2.4 Hz, 1H), 7.90 (d, J=2.4 Hz, 1H), 7.32 (br s, 2H). MS (ES+): m/z 121 (M+H)+.

Statistics shows that 3-Aminopyrazine-2-carboxamide is playing an increasingly important role. we look forward to future research findings about 32587-10-3.

Reference:
Patent; TargeGen, Inc.; US2007/259876; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32587-10-3, name is 3-Aminopyrazine-2-carboxamide, A new synthetic method of this compound is introduced below., category: Pyrazines

To a stirred solution of 3-aminopyrazine-2-carboxamide (1 g, 7.24 mmol, prepared according to International Patent Application Publication No. W0201 1054922) and NaOAc (200mg, 2.44 mmol) in HOAc (15 mE) was added Br2 (0.45 mE) dropwise at 0C for 1 hour, and then it was stirred at 50C for 8 hours. After the mixing, it was poured into ice-water and filtrated, the crude product of 3-amino-6-bromopyrazine-2-carboxamide as brown solid (1.5 g, yield: 95%) was obtained. ?H-NMR (DMSO-d6, 400 MHz) 8.30 (s, 1H), 7.93 (s, 2H), 7.66 (s, 2H). MS (M+H):217/219.

The synthetic route of 32587-10-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/205593; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 32587-10-3, name is 3-Aminopyrazine-2-carboxamide, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 32587-10-3

Step 2: Synthesis of Intermediate C’ as described in the general scheme: 2-amino-3-amido-5-bromopyrazine A mixture of B’ (210 g, 1.52 mM), acetic acid (630 mL) and sodium acetate tri-hydrate (310 gm, 2.28 mM) is warmed up to 50 C. To this solution is added bromine (93.43 mL, 1824 mM) in acetic acid (105 mL) in 1.5 hrs and the mixture is stirred for 30 min at 50-55 C. The reaction mixture is cooled to 15 C., water (2.1 L) is added over 20-30 min and the resulting suspension is stirred for another 30 min. The Solid is isolated by filtration, washed with water (210 mL*2) and dried at 45 C. under vacuum to afford C’, used in the next step without further treatment.

According to the analysis of related databases, 32587-10-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; WIGERINCK, Piet Tom Bert Paul; ANDREWS, Martin James Inglis; De WEER, Marc Maurice Germain; SABOURAULT, Nicholas Luc; KLUGE, Stefan Christian; US2011/118269; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 32587-10-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 32587-10-3 as follows.

EXAMPLE 3 Synthesis of 3-Aminopyrazine-2-carbonitrile (Intermediate 2) To a solution of intermediate 1 (3.5 g, 25 mmol) in DMF (40 mL) at RT was added POCl3 (4.5 mL, 49 mmol) slowly. The resulting mixture was heated at 80 C. for 15 min and then cooled to RT. The mixture was poured into ice water and the mixture neutralized with 10% NaOH solution. The resulting solid was filtered and redissolved in 5% HCl. The solution was heated at 70 C. for 30 min and the resulting solid filtered. After thoroughly washed with water, the title compound was obtained as a brown solid (1.7 g, 56%). 1H NMR (500 MHz, DMSO-d6): delta 8.28 (d, J=2.4 Hz, 1H), 7.90 (d, J=2.4 Hz, 1H), 7.32 (br s, 2H). MS (ES+): m/z 121 (M+H)+.

According to the analysis of related databases, 32587-10-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TargeGen, Inc.; US2007/259876; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 32587-10-3, A common heterocyclic compound, 32587-10-3, name is 3-Aminopyrazine-2-carboxamide, molecular formula is C5H6N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(d) In 5 mL of trifluoroacetic acid was dissolved 100 mg of 3-amino-2-pyrazinecarboxamide. At an ice-cooled temperature, 10% fluorine gas (a fluorine gas diluted with nitrogen gas) was introduced at a rate of 45 mL per minute for a period of 36 minutes. Then, while elevating the temperature from the ice-cooled temperature to room temperature, nitrogen gas was introduced for one hour. The reaction mixture was concentrated under reduced pressure to obtain 305 mg of an oily product. Of the oily product thus obtained, a 251 mg portion was dissolved in 9.3 mL of water and heated under reflux for 4 hours, The liquid reaction mixture was cooled to room temperature, and the deposited precipitate was filtered off. The filtrate was concentrated under reduced pressure, and the solid product thus obtained was purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=2:1] to obtain 9 mg of 3-amino-6-fluoro-2-pyrazinecarboxamide as a solid product.

The synthetic route of 32587-10-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem