Category: 322-46-3

Stabilizing biochemically important intermediates through metal coordination. 5,8-Bis(trimethylsilyl)-5,8-dihydropteridine and its deaza derivative was written by Bessenbacher, Christian;Kaim, Wolfgang. And the article was included in Journal of Organometallic Chemistry in 1989.Reference of 322-46-3 This article mentions the following:

Reductive trimethylsilylation of pteridine and its deaza derivatives 1,4,6- and 1,4,5-triazanaphthalene and quinoxaline yields the primary reduced forms of these heterocycles, which contain the 1,4-dihydro-1,4-diazine ring with 8 conjugated 锜?electrons as the only low mol. weight products. Although the organometallic substituents stabilize these biochem. important yet normally short-lived dihydro forms and so allow unambiguous characterization by NMR, the non-crystalline, colored compounds are still highly reactive. Unexpectedly, the deaza derivatives prove to be less electron-rich than the silylated dihydropteridine despite a clear increase in the electron d. in the aromatic ring. The characteristic conformational flexibility of these intermediates is responsible for this inverse annulation effect. Reductive trimethylsilylation of 1,5-naphthyridine yields the 1-trimethylsilyl-1,4-dihydro derivative as the major product. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Reference of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reaction of 1-ethoxyalylmethylpyrido[2,3-b]pyrazinium bromide with ammonium acetate: synthesis of imidazo[1′,2′:1,2]pyrido[5,6-b]pyrazines was written by Blache, Yves;Gueiffier, Alain;Chavignon, Olivier;Elhakmaoui, Ahmed;Viols, Henry;Teulade, Jean Claude;Milhavet, Jean Claude;Dauphin, Gerard;Chapat, Jean Pierre. And the article was included in Heterocycles in 1994.Recommanded Product: Pyrido[2,3-b]pyrazine This article mentions the following:

The synthesis of some imidazo[1,2′:1,2]pyrido[5,6-b]pyrazines I (R¹ = H, Me, R² = H; R¹ = R² = Me) by treatment of quaternary salts of pyrido[2,3-b]pyrazines II (R³ = H) with ammonium acetate in AcOH media is described. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Recommanded Product: Pyrido[2,3-b]pyrazine).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Recommanded Product: Pyrido[2,3-b]pyrazine

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Self-consistent field molecular orbital calculations of ultraviolet electronic spectra of azanaphthalenes with the variable 灏?approximation was written by Tinland, Bernard. And the article was included in Theoretica Chimica Acta in 1967.Product Details of 322-46-3 This article mentions the following:

The stable crystal field M.O. calculations of uv electronic spectra of 10 azonaphthalenes with the variable 灏?approximation (K. Nishimoto, et al., 1966) are presented. The transition energies and bond lengths of these mols. were calculated and the results are in satisfactory agreement with experiment In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Product Details of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazines are chemical compounds (technically called 閳ユ笗ethoxypyrazines閳? found in grape skin and stems that are responsible for many 閳ユ笀reen閳?flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Product Details of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Azanaphthalenes. I. Hueckel orbital calculations was written by Wait, S. C. Jr.;Wesley, John W.. And the article was included in Journal of Molecular Spectroscopy in 1966.Recommanded Product: 322-46-3 This article mentions the following:

Energy levels, wave functions, and charge ds. are reported for 74 azanaphthalenes. Calculations were performed by using the Hueckel method. Comparison of the lowest singlet-singlet transition with that calculated by the Pariser-Parr method is given for 21 compounds In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Recommanded Product: 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Recommanded Product: 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Coordination ambivalence and fluxional behavior in mono- and binuclear pentacarbonyltungsten complexes of pteridine and its deaza derivatives was written by Bessenbacher, Christian;Kaim, Wolfgang. And the article was included in Journal of Organometallic Chemistry in 1989.HPLC of Formula: 322-46-3 This article mentions the following:

WL(CO)₅ (L = pteridine (pte), 1,5-naphthyridine, (npt), 1,4,5-triazanaphthalene (tan), 1,4,6-triazanaphthalene) and W₂(CO)₁₀L¹ (L¹ = pt, npt) were prepared Unambiguous identification of coordination sites was only possible by use of high-resolution ¹H NMR because the chem. shifts and spin-spin coupling constants are characteristically affected by W(CO)₅-coordination to neighboring N centers. Fluxional behavior with respect to the peri coordination sites was observed for W(CO)₅(1,4,5-tan) and W(CO)₁₀(pte). Competition between the more basic pyridine or pyrimidine and the better π backdonating pyrazine N centers leads to various positions for the nondegenerate equilibrium between linkage isomers. Cyclic voltammetry and solvent-dependent charge transfer absorption spectra of the complexes reveal low-lying π^* levels which can become populated after chem. or electrochem. reduction, the spin distribution in the centrosym. binuclear complex of 1,5-naphthyridine anion radical was fully characterized using ESR and results from MO calculations In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3HPLC of Formula: 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.HPLC of Formula: 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis, characterization and molecular structures of some tetraosmium carbonyl clusters containing pyridine or phenanthroline type ligands was written by Choi, Ya-Yin;Wong, Wing-Tak. And the article was included in Journal of Organometallic Chemistry in 1999.COA of Formula: C7H5N3 This article mentions the following:

The reactions of activated tetraosmium carbonyl cluster [Os₄(μ-H)₄(CO)₁₁(NCMe)] (1) with monopyridyl ligands give new clusters [Os₄(μ-H)₄(CO)₁₁,(pyp)] (3) and [Os₄(μ-H)₄ (CO)₁₁(pya)] (4) (pyp = pyrido[2,3-b]pyrazine, pya = 4-pyridinecarboxaldehyde). Similarly, the reactions of [Os₄(μ-H)₄(CO)₁₀(NCMe)₂] (2) with bipyridyl or phenanthroline type ligands afford [Os₄(μ-H)₄(CO)₁₀(bpy)] (5), [Os₄(μ-H)₄ (CO)₁₀(4,4′-diphenyl-2,3-bipyridine)] (6), [Os₄(μ-H)₄(CO)₁₀(phen)] (7), [Os₄(μ-H)₄(CO)₁₀(2,9-dimethyl-4,4′-diphenyl-1,10-phenanthroline)] (8), and [Os₄(μ-H)₄(CO)₁₀(dipyrido[3,2-a:2′,3′-c]phenazine)] (9), which exhibit interesting ring conformations. Treatment of 2 with the N-P mixed donor ligand diphenyl-2-pyridylphosphine (dppy) gives a novel bridging cluster [Os₄(μ-H)₄(CO)₁₀(dppy)] (10). In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3COA of Formula: C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.COA of Formula: C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Time-resolved electron paramagnetic resonance investigation of photochemical reactions. Hydrogen abstraction in azaaromatics and carbonyls was written by Yamauchi, Seigo;Hirota, Noboru. And the article was included in Journal of Physical Chemistry in 1984.Related Products of 322-46-3 This article mentions the following:

Transient ESR spectra were observed for the intermediate radicals in the photoinduced H abstractions of azaarom. mols. and carbonyls in Me₂CHOH. Temperature dependence was examined at -10 to -90°. The intermediate radicals are assigned from the spectra with partially resolved hyperfine structures. The precursory excited states for the reactions are determined from the signal polarities, and their properties are discussed in terms of the possible CIDEP mechanisms. The reactions occur from the T₁(nπ^*) states with neg. D values or the T₁(ππ^*) states with pos. D in the cases of azaaroms. In aromatic carbonyls the reactions occur from the T₁(nπ^*) or T₂(nπ^*) states with neg. D values, while in aliphatic carbonyls, from the T₁(nπ^*) states with pos. D values. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Related Products of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Related Products of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

A unique, rigid porous coordination polymer with 1,4,5-triazanaphthalene and mixed-valence Cu as the bridging metal was written by van Albada, Gerard A.;Ghazzali, Mohamed;Al-Farhan, Khalid;Mutikainen, Ilpo;Reedijk, Jan. And the article was included in Inorganic Chemistry Communications in 2011.Product Details of 322-46-3 This article mentions the following:

A novel mixed-valence Cu(I)/Cu(II) compound with the bridging ligand 1,4,5-triazanaphthalene (tan) is reported, having the overall formula [Cu₂(tan)₄](ClO₄)₃. The synthesis, x-ray crystal structure and preliminary spectroscopic properties are presented. The coordination of Cu(I) is tetrahedral, and that of Cu(II) is square planar. The packing of the units generates a 3D network with spaces in the cavities, available for the counteranions and accessible for small solvent mols. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Product Details of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Product Details of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The electronic spectra of N-heteroaromatic systems. IX. n → π transitions of polycyclic azines was written by Mason, S. F.. And the article was included in Journal of the Chemical Society in 1962.Reference of 322-46-3 This article mentions the following:

The visible and ultraviolet spectra of some polycyclic azines were measured in hydrocarbon and hydroxylic solvents. The frequencies of the n → π bands are determined primarily by the energy of the lowest unoccupied orbital in the corresponding aromatic hydrocarbon and the 1-electron charge ds. in that orbital at the positions occupied by N atoms, together with ground-state interaction between the lone pair orbitals in the ortho diazines. The intensities of the diazine n → π bands increase with the sum of the 1-electron charge ds. at the N positions of the lowest unoccupied π orbital. Compounds investigated are quinoline, quinoxaline, 1,5- and 1,8-naphthyridine, cinnoline, quinazoline, phthalazine, 1,2,4-, 1,4,5-, and 1,4,6-triazanaphthalene, 1,3,5,8-and 1,4,5,8-tetraazanaphthalene, and phenazine. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Reference of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Structural and magnetic behavior of the kinked chain Cu(hfac)₂(tan) and its relevance to Cu(NO₃)₂(tan) (hfac = hexafluoroacetylacetonate; tan = 1,4,5-triazanaphthalene) was written by Manson, Jamie L.. And the article was included in Inorganic Chemistry in 2003.Electric Literature of C7H5N3 This article mentions the following:

When stoichiometric amounts of Cu(hfac)₂·H₂O and 1,4,5-triazanaphthalene (tan) were combined in MeOH, green crystals of Cu(hfac)₂(tan) were formed. Its structure was determined at low temperature (P2₁/c; a 8.3308(4), b 14.8945(7), c 18.3046(10) Å, β 99.298(2)°) and found to consist of a novel kinked-chain arrangement where N atoms on opposite sides of the tan ligand bridge Cu(hfac)₂ moieties together. Long axial Cu-N bonds lead to rather weak (J/k_B = -0.06(5) K) antiferromagnetic interactions according to a Bonner-Fisher fit of the magnetic susceptibility data. The magnetic behavior demonstrated by Cu(hfac)₂(tan) contrasts markedly with that of Cu(NO₃)₂(tan), as reported by Hatfield and co-workers, and is attributed to the differing orientations of the Cu d_x²-y² magnetic orbital. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Electric Literature of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Electric Literature of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem