Category: 322-46-3

Ni@zeolite-Y nano-porous: preparation and application as a high efficient catalyst for facile synthesis of quinoxaline, pyridopyrazine, and inadoloquinoxaline derivatives was written by Kalhor, Mehdi;Seyedzade, Zahra. And the article was included in Iranian Journal of Chemistry & Chemical Engineering in 2019.Name: Pyrido[2,3-b]pyrazine This article mentions the following:

In this research, by a simple and modified method, nanoporous of Ni(II) ion loaded Y-type zeolite (NNZ) was designed and applied as a novel highly efficient catalyst for the synthesis of quinoxalines, pyrido[2,3-b]pyrazines, and indolo[2,3-b]quinoxalines 3a-s. These heterocycles were obtained through a one-pot condensation reaction of aryl-1,2-diamines with 1,2-diketones or the isatin in the presence of the catalytic amount of Ni@zeolite-Y in ethanol or acetic acid at room temperature giving good to excellent yield. The structure of entitled catalyst was identified with FT-IR spectroscopy, Energy Dispersive X-ray (EDX), SEM (SEM) and Brunauer-Emmett-Teller (BET) anal. This method has some advantages such as the use of inexpensive, safety, stable and recyclable catalyst, high yields, short reaction times, and easy isolation of the product. It can be claimed that this approach in simplicity covers the goals of green chem. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Name: Pyrido[2,3-b]pyrazine).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Name: Pyrido[2,3-b]pyrazine

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The infrared spectra of some diaza- and triazanaphthalenes and of 1,4,5,8-tetraazanaphthalene was written by Armarego, W. L. F.;Barlin, G. B.;Spinner, E.. And the article was included in Spectrochimica Acta in 1966.Category: pyrazines This article mentions the following:

The ir spectra of 1,2-, 1,3-, 1,4-, 1,5-, 1,6-, 1,7-, and 1,8-diaza-, 1,3,4-, 1,3,5-, 1,3,6-, 1,3,7-, 1,3,8-, 1,4,5-, and 1,4,6-triaza-, and 1,4,5,8-tetraazanaphthalene, and the Raman spectrum of 1,5-diazanaphthalene, have been determined and correlated. Band assignments for 1,4,5,8-tetraaza- and 1,5-diazanaphthalene are discussed in relation to those for naphthalene. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Category: pyrazines).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Category: pyrazines

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Triazanaphthalenes. IV. Covalent hydration in 1,4,5-tri- azanaphthalenes was written by Albert, Adrien;Barlin, G. B.. And the article was included in Journal of the Chemical Society in 1963.Name: Pyrido[2,3-b]pyrazine This article mentions the following:

Syntheses, ionization constants, and ultraviolet spectra are presented for some 1,4,5-triazanaphthalenes. By rapid-reaction techniques, it is shown that the cation of the 2-hydroxy derivative binds H₂O covalently at the 3,4-bond. This is the first adduct found to be stabilized by a 2-aminopyridinium type of resonance. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Name: Pyrido[2,3-b]pyrazine).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Name: Pyrido[2,3-b]pyrazine

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Dihydration (covalent) of condensed pyrazine heterocycles was written by Batterham, T. J.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1966.Recommanded Product: 322-46-3 This article mentions the following:

Proton N.M.R. measurements show that the cations of 1,4,5- and 1,4,6-triazanaphthalene, 1,4,5,8-tetraazanaphthalene, and five of their derivatives add 2 mols. of water reversibly, across the 1,2 and 3,4 C:N bonds. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Recommanded Product: 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Recommanded Product: 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Far-infrared spectra and the rotational isomerism of symmetrical tetrachloro- and tetrabromoethane was written by Chantry, G. W.;Gebbie, H. A.;Griffiths, P. K.;Lake, R. F.. And the article was included in Spectrochimica Acta in 1966.Synthetic Route of C7H5N3 This article mentions the following:

Far-ir spectra have been recorded of liquid samples of sym. tetrachloro- and tetrabromoethane. These have been used in conjunction with earlier work to derive complete assignments for both rotational isomers of both mols. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Synthetic Route of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazines are chemical compounds (technically called 閳ユ笗ethoxypyrazines閳? found in grape skin and stems that are responsible for many 閳ユ笀reen閳?flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Synthetic Route of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

A facile, catalyst-free mechano-synthesis of quinoxalines and their in-vitro antibacterial activity study was written by Bhutia, Zigmee T.;Prasannakumar, Geethika;Das, Avijit;Biswas, Malabika;Chatterjee, Amrita;Banerjee, Mainak. And the article was included in ChemistrySelect in 2017.SDS of cas: 322-46-3 This article mentions the following:

A catalyst-free, greener and highly efficient method for the synthesis of quinoxaline derivatives I (R¹ = Ph, Me, H, etc.; R² = H, Me; R³ = H, Me, Cl, NO₂; R⁴ = H, Me; X = CH, N) involving simple liquid assisted hand-grinding (LAG) in a mortar and pestle was developed. The mechanochem. agitation under LAG was sufficient enough for the smooth condensation of both aromatic and heteroaromatic 1,2-diamines with a variety of 1,2-dicarbonyl compounds to afford the corresponding quinoxalines in high yields. Several of these quinoxaline derivatives inhibited the growth of Mycobacterium smegmatis in moderate to good effect. Simple substitution in the quinoxaline ring was found to be more effective in antibacterial agents than bulky substitution. In particular, pyrido[2,3-b]pyrazines I (R¹ = H, CH₃; R² = R⁴ = H; R³ = H, Br; X = N) showed better activity than others. Overall, the key advantages of this method were simplicity of operation, catalyst-free condition, solvent-less synthesis, low E-factor, cleaner reaction profile, devoid of work-up step, easy purification and shorter reaction times, and the new series of pyrido[2,3-b]pyrazines were good antibacterial agents against M. smegmatis. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3SDS of cas: 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.SDS of cas: 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Calculation of electronic spectra of azabenzenes and azanaphthalenes by the Pariser-Parr-Pople method was written by Favini, Giorgio;Vandoni, Ida;Simonetta, Massimo. And the article was included in Theoretica Chimica Acta in 1965.Recommanded Product: 322-46-3 This article mentions the following:

The semiempirical treatments of Pariser and Parr and of Pople were used to calculate transition energies and intensities of the 锜?锜?sup>* bands in the electronic spectra of 31 azines (azabenzenes and azanaphthalenes). A comparison with exptl. data and a discussion of the wave functions for the ground and excited states are presented. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Recommanded Product: 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Recommanded Product: 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis of pyrido[2,3-b]pyrazines and study of their antitumor activity was written by Postovskii, I. Ya.;Charushin, V. N.;Mokrushina, G. A.;Kotovskaya, S. K.;Barybin, A. S.;Chupakhin, O. N.;Chernyshev, A. I.. And the article was included in Khimiko-Farmatsevticheskii Zhurnal in 1982.Reference of 322-46-3 This article mentions the following:

Cyclocondensation of I (R = Me₂N, morpholino, piperidino) with glyoxal gave 50-60% II which were quaternized with MeI to give 60-64% III. II (R = Me₂N) and III (R = Me₂N) inhibited sarcoma 37 in mice 50-55% at 50-100 娓璯/kg dosage. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Reference of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

A study of solvent effects on the phosphorescence properties of flavins was written by Brunk, G. R.;Martin, K. A.;Nishimura, A. M.. And the article was included in Biophysical Journal in 1976.SDS of cas: 322-46-3 This article mentions the following:

A combination of zero-field triplet-state techniques was used to study the excited electronic states of a series of flavin and flavin related mols. both in single crystals and glass matrixes. Particular attention was given to the effects of solvent interaction on the triplet-state properties of the flavin mols. The total phosphorescence decay rate constants at 1.4 K are reported for the flavin mols. in polar and nonpolar solvents. The rate constants were correlated to the degree of solvent interaction. Results indicated possible complex formation between the isoalloxazine and adenine groups in FAD. The results and possible interpretation on the flavoenzyme, L-amino acid oxidase, are presented. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3SDS of cas: 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, 浼?hydroxyketone, 浼?methyl ketone. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.SDS of cas: 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Estimation of electron affinity based on structure activity relationships was written by Hilal, S. H.;Carreira, L. A.;Karickhoff, S. W.;Melton, C. M.. And the article was included in Quantitative Structure-Activity Relationships in 1993.Related Products of 322-46-3 This article mentions the following:

Electron affinity for a wide range of organic mols. was calculated from mol. structure using the chem. reactivity models developed in SPARC. These models are based on fundamental chem. structure theory applied to the prediction of chem. reactivities for organic mols. strictly from mol. structure. The energy differences between the LUMO state and the HOMO state for a mol. of interest are factored into mechanistic components including the field, sigma induction and resonance contributions to these energy differences. The RMS deviation between observed and calculated electron affinities was found to be less than 0.14 e.v. for a large set of organic mols. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Related Products of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Related Products of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem