Category: 32111-28-7

32111-28-7, name is N-Methylpyrazin-2-amine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C5H7N3

In a 100 mL two-neck flask, 2-methylaminopyrazine (114 muL, 1.2 mmol), N-(3-bromo-5-methoxyphenyl)-benzamide (244 mg, 0.8 mmol) were added,Potassium phosphate (339 mg, 1.6 mmol), copper iodide (15 mg) and anhydrous DMSO (15 mL) were reacted overnight at 110C under argon atmosphere.After the reaction solution was cooled, 15 mL of water was added and the mixture was extracted with ethyl acetate (15 mL×2), and the solvent was removed under reduced pressure.The residue was purified by silica gel chromatography (petroleum ether/ethyl acetate gradient) to give N-(3-methoxy-5-(methyl-2-pyrazinylamino)phenyl)-benzamide 122 mg The yield is 50%.

The synthetic route of 32111-28-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sun Yat-sen University; Chinese Academy Of Sciences Guangzhou Bio-pharmaceutical And Health Institute; Yan Ming; Zhang Tianyu; Zhang Niuniu; Liu Zhiyong; Qian Lu; Tang Yunxiang; Cheng Yajuan; Zhang Xuejing; (25 pag.)CN107973727; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 32111-28-7, A common heterocyclic compound, 32111-28-7, name is N-Methylpyrazin-2-amine, molecular formula is C5H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A magnetically stirred solution of xanthate (2.0 equiv) and pyrazine (1.0 equiv) in 1, 2-dichloroethane (1.0mmol/mL according to the xanthate) was refluxed for 15min under a flow of nitrogen. Then dilauroyl peroxide (DLP) was added portionwise (20mol % according to the xanthate) every hour until total consumption of one substrate. The reaction mixture was then cooled to room temperature and the solvent was evaporated under reduced pressure. Unless otherwise specified, the crude product was purified by flash chromatography on silica gel.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Huang, Qi; Qin, Ling; Zard, Samir Z.; Tetrahedron; vol. 74; 40; (2018); p. 5804 – 5817;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 32111-28-7, name is N-Methylpyrazin-2-amine, molecular formula is C5H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 32111-28-7

To a stirred solution of N-methylpyrazin-2-amine (1 g, 9.2 mmol) in dimethyl sulfoxide (20 ml) / water (0.4 ml) at 10 C was added portionwise N-lodosuccinimide (4.1 g, 18.4 mmol). The reaction mixture was then allowed to warm slowly to room temperature and stirred at that temperature overnight. An additonal aliquot of N-lodosuccinimide (4.1 g,18.4 mmol) was then added at room temperature. After stirring for 7hr, the reaction mixture was poured onto ice (20 g). The precipitate was collected, washed with cold water (20 ml), and dried to provide the title compound (2.15 g, 65 %). 1H NMR (300MHz, DMSO-d6) 5(ppm): 8.14(s, 1 H), 6.69 (br, 1 H), 2.77(d, 3 H, J=4.5 Hz); ESI-MS(-):360.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 32111-28-7, its application will become more common.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; EDMUNDS, Andrew; MUEHLEBACH, Michel; STOLLER, Andre; LOISELEUR, Olivier; BUCHHOLZ, Anke; HUETER, Ottmar Franz; BIGOT, Aurelien; HALL, Roger Graham; EMERY, Daniel; JUNG, Pierre Joseph Marcel; LU, Long; WU, Yaming; CHEN, Ruifang; WO2015/715; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

32111-28-7, The chemical industry reduces the impact on the environment during synthesis 32111-28-7, name is N-Methylpyrazin-2-amine, I believe this compound will play a more active role in future production and life.

To a stirred solution of aminopyrazine 4 (5.0 mmol) in dimethyl sulfoxide (10 mL)/water (0.20 mL) at 10 C. was added N-bromosuccinimide (10 mmol) in portions. The reaction mixture was then allowed to warm to room temperature slowly and stirred at that temperature overnight. An additional aliquot of N-bromosuccinimide (10 mmol) was then added at room temperature. After stirring for 6.5 h, the reaction mixture was poured onto ice (30 g). The precipitate was collected, washed with cold water (2¡Á10 mL), and dried to provide the product 2, which could be purified by column chromatography, but was usually used in the next step without purification. ; Step B: 3,5-Dibromo-N-methylpyrazin-2-amine Prepared from the product of Step A according to general procedure 3 providing the dibromopyrazine (700 mg, 44%) as a yellow solid; 1H NMR (300 MHz, CDCl3) delta 8.07 (s, 1H), 5.26 (br s, 1H), 3.03-3.01 (d, J=5.0 Hz, 3H).

The chemical industry reduces the impact on the environment during synthesis N-Methylpyrazin-2-amine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Alcon, Inc.; US2006/142307; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem