Category: 312736-50-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 312736-50-8, name is 3,5-Dichloropyrazine-2-carboxamide belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 3,5-Dichloropyrazine-2-carboxamide

107261 To a solution of 3,5-dichloropyrazine-2-carboxamide (Example 12, Step 2, 52 g, 0.27 mol) in acetonitrile (1 L) was added POC13 (146 g, 89 mL, 0.95 mol) at room temperature. The mixture was heated to 90-100 C for 4 h. The mixture was cooled to room tempetature and poured slowlyinto a vigorously stirring solution of saturated aq. NaHCO3. Evolution of gas was observed. The mixture was extracted with EtOAc (3 x). The combined organic layers were dried over sodium sulfate then concentrated under reduced pressure to give a residue. The residue was purified by silica gel chromatography (0-30% EtOAc in hexanes) to give the title compound as a pale yellow solid. ?H NIVIR (400 MHz, CDC13): ppm 8.64 (s, 1H): ?3C NMR (101 IVIFIz, CDC13) ppm 150.8,150.43, 143.24, 128.06, 113.06.

The synthetic route of 312736-50-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FLX BIO, INC.; BECK, Hilary, Plake; BIANNIC, Berenger; BUI, Minna Hue, Thanh; HU, Dennis, X.; KETCHAM, John, Michael; POWERS, Jay, Patrick; REILLY, Maureen, Kay; ROBLES-RESENDIZ, Omar; SHUNATONA, Hunter, Paul; WALKER, James, Ross; WUSTROW, David, Juergen; YOUNAI, Ashkaan; ZIBINSKY, Mikhail; (396 pag.)WO2018/22992; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 312736-50-8, name is 3,5-Dichloropyrazine-2-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3,5-Dichloropyrazine-2-carboxamide

A mixture of 3,5-dichloropyrazine-2-carboxamide (3b, 450 mg, 2.34 mmol), 3-(methanesulfonyl)aniline (441 mg, 2.58 mmol), DIPEA (408 muL, 2.34 mmol) and 1,4-dioxane (20 mL) was stirred 110 C for 60 h. After the mixture was cooled, water was added, and the resulting slurry was extracted with EtOAc. The organic layer was dried over anhydrous MgSO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (CHCl3/MeOH=100:0 to 50:1).The resulting product was washed with EtOAc to give 4b (425 mg,55%) as a pale yellow solid. 1H NMR (DMSO-d6): delta 3.24 (3H, s),7.55-7.77 (2H, m), 7.90-8.04 (1H, m), 8.06-8.36 (3H, m), 8.50 (1H, s),11.73 (1H, s); MS (FAB) m/z [M+H]+ 327.

The synthetic route of 3,5-Dichloropyrazine-2-carboxamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Iikubo, Kazuhiko; Kurosawa, Kazuo; Matsuya, Takahiro; Kondoh, Yutaka; Kamikawa, Akio; Moritomo, Ayako; Iwai, Yoshinori; Tomiyama, Hiroshi; Shimada, Itsuro; Bioorganic and Medicinal Chemistry; vol. 27; 8; (2019); p. 1683 – 1692;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 312736-50-8 as follows. Computed Properties of C5H3Cl2N3O

107261 To a solution of 3,5-dichloropyrazine-2-carboxamide (Example 12, Step 2, 52 g, 0.27 mol) in acetonitrile (1 L) was added POC13 (146 g, 89 mL, 0.95 mol) at room temperature. The mixture was heated to 90-100 C for 4 h. The mixture was cooled to room tempetature and poured slowlyinto a vigorously stirring solution of saturated aq. NaHCO3. Evolution of gas was observed. The mixture was extracted with EtOAc (3 x). The combined organic layers were dried over sodium sulfate then concentrated under reduced pressure to give a residue. The residue was purified by silica gel chromatography (0-30% EtOAc in hexanes) to give the title compound as a pale yellow solid. ?H NIVIR (400 MHz, CDC13): ppm 8.64 (s, 1H): ?3C NMR (101 IVIFIz, CDC13) ppm 150.8,150.43, 143.24, 128.06, 113.06.

According to the analysis of related databases, 312736-50-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FLX BIO, INC.; BECK, Hilary, Plake; BIANNIC, Berenger; BUI, Minna Hue, Thanh; HU, Dennis, X.; KETCHAM, John, Michael; POWERS, Jay, Patrick; REILLY, Maureen, Kay; ROBLES-RESENDIZ, Omar; SHUNATONA, Hunter, Paul; WALKER, James, Ross; WUSTROW, David, Juergen; YOUNAI, Ashkaan; ZIBINSKY, Mikhail; (396 pag.)WO2018/22992; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 312736-50-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 312736-50-8 as follows.

solution of the compound (5.0 g, 13.3 mmol) obtained in Preparation Example 13.1 in MeCN (100 mL) was charged with POCl3 (6.76 mL, 72.3 mmol) and stirred at 80 for 4 h. After dilution with water, the mixture was extracted with EtOAc and washed with brine. The organic layer was dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The crude product was purified by column chromatography (20% n-hexane/EtOAc) to afford 3,5-dichloropyrazin-2-carbonitrile (2.94 g, 65%) as a solid.

According to the analysis of related databases, 312736-50-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ST Pharm Co. Ltd.; Kim, Kyeong Jin; Kim, Kwang Rok; Kim, Wook Il; Bang, Hyeong Tae; Yoon, Ji Hye; Im, Hwan Jeong; Ho, Cheong Nyeong; (50 pag.)KR2016/7347; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem