In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 30818-40-7 as follows. Safety of 3,5,6-Trichloropyrazine-2-carbonitrile
101881 To a solution of 3,5,6-trichloropyrazine-2-carbonitrile (5 g, 23.99 mmol) in dioxane (20 mL) at 0 C under nitrogen was added propan-2-amine (4.09 mL, 48.0 mmol). The reaction solution was stirred at 23 oC for 4 h, then quenched with brine (300 mL) and extracted with ethyl acetate (2 x 200 mL). The organic layers were combined, dried over anhydrous MgSO4, filtered and concentrated. The residue was purified via flash column chromatography (5-30% EtOAc in heptane) to afford the title compound (5 g, 90%). 1H NMR (500 MHz, DMSO-d6) oe ppm 1.23 (d, J=6.83 Hz, 6 H) 4.22 (dt, J=8.05, 6.47 Hz, 1 H) 8.27 (d, J=7.81 Hz, 1 H); ESI-MS mlz [M+H]+ 231.0.
According to the analysis of related databases, 30818-40-7, the application of this compound in the production field has become more and more popular.