Related Products of 29094-61-9, A common heterocyclic compound, 29094-61-9, name is Glipizide, molecular formula is C21H27N5O4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Glipizide (445.5 mg, 1.0 mmol) was dissolved in DMSO (anhydrous, 10ML). Sodium amide (76.03mg, 2. 0 mmol) was then added. The reaction mixture was stirred at room temperature for 10 min. DTPA-dianhydride (357.32 mg, 1.0 mmol) was dissolved in DMSO (anhydrous, 10ML). Sodium amide (76.03 mg, 2.0 mmol) was then added. The reaction mixture was stirred at room temperature for 10 min. DTPA-dianhydride (357.32 mg, 1.0 mmol) dissolved in 5 ml DMSO (anhydrous) was added and the mixture was stirred for 4 hours. The mixture was added with water (10 mL), followed by 1N-sodium hydroxide solution (3 mL) and stirred for 2 hours. The solid was filtered and washed with water. This recovered starting material was 142.6 mg (32%) after drying under vacuum. The aqueous phase was dialyzed with membrane (MW CO < 500) for 2 days. DTPA-GLP (506.6 MG, ; 61.7% yield) as a white solid was gathered after lyophilization. The synthetic scheme is shown in Figure 8. Figures 9-17 SHOWED LH-, L3C-NMR spectrum and assignment and mass spectrometry of DTPA-glipizide. The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.