Category: 2873-36-1

Paravisini, Laurianne; Soldavini, Ashley; Peterson, Julie; Simons, Christopher T.; Peterson, Devin G. published the artcile< Impact of bitter tastant sub-qualities on retronasal coffee aroma perception>, Product Details of C11H18N2O2, the main research area is coffee bitter tastant quality retronasal aroma profile.

The impact of different bitter taste compounds on the retronasal perception of coffee aroma was investigated. A sorted napping experiment was carried out on thirteen compounds at iso-intense bitter concentrations Differences in perceptual bitter sub-qualities among the compounds were reported by Multidimensional Scaling (MDS) and Multiple Factor Anal. (MFA) analyses. Seven exemplar compounds were further selected to investigate the impact of taste sub-qualities on cross-modal flavor interactions. In general, the different bitter compounds, when paired with a coffee aroma isolate, significantly modified the perception of the retronasal coffee aroma profile. Interestingly, the three bitter compounds endogenous to coffee had the most similar impact on the coffee aroma profile. Further sensory anal. of these sample sets indicated no significant effect of the bitter compounds on the orthonasal perception. Gas Chromatog./Mass Spectrometry (GC/MS) anal. of the volatile composition of the samples headspace also indicated negligible impact of the bitter compounds on aroma release. Altogether evidence of cross-modal interactions occurring at a higher cognitive level were demonstrated in a complex food sample, supporting the importance of multi-modal sensory integration on flavor perception.

PLoS One published new progress about Bitterness. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Product Details of C11H18N2O2.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Lozano-Gonzalez, M.; Ovalle-Magallanes, B.; Rangel-Grimaldo, M.; De la Torre-Zavala, S.; Noriega, L. G.; Tovar-Palacio, C.; Tovar, A. R.; Mata, R. published the artcile< Antidiabetic in vitro and in vivo evaluation of cyclodipeptides isolated from Pseudomonas fluorescens IB-MR-66e>, Safety of (3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione, the main research area is cyclodipeptides Pseudomonas antidiabetic postprandial state glucosidase.

Three cyclodipeptides [cyclo(L-Pro-L-Leu), 1; cyclo(L-Pro-L-Val), 2; and cyclo(L-Pro-L-Phe), 3] were isolated from Pseudomonas fluorescens IB-MR-66e. The structures were established by spectral means and corroborated by synthesis. The antidiabetic potential of compounds 1-3 was explored in vivo, in vitro and in silico. The three peptides showed important inhibitory activity against the α-glucosidase enzyme. Further anal. in vivo using a sucrose tolerance test corroborated that compounds 1 and 3 (1-30 mg kg-1) significantly reduced the postprandial state. Peptide 1 (1-30 mg kg-1) also reduced the postprandial peak after a glucose challenge and exhibited significant hypoglycemia during an insulin tolerance test; thus, its antidiabetic action involved also an improvement of insulin utilization not related to Akt phosphorylation nor to an increment in mitochondrial bioenergetics nor insulin secretion.

New Journal of Chemistry published new progress about Antidiabetic agents. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Safety of (3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Lu, Shengsheng; Hu, Jianan; Xie, Xi; Zhou, Runhong; Li, Fangfang; Huang, Ruifeng; He, Jian published the artcile< Secondary Metabolites with Cytotoxic Activities from Streptomyces sp. BM-8 Isolated from the Feces of Equusquagga>, Synthetic Route of 2873-36-1, the main research area is Equus Streptomyces secondary metabolites feces; Streptomyces sp. BM-8; aliphatic acid; animal intestinal bacteria; cytotoxic activities; secondary metabolites.

A new aliphatic acid, compound 1, together with six known metabolites, including nonactic acid (2), homononactic acid (3), Et homononactate (4), homononactylhomononactate (5), valinomycin (6), and cyclo-(Pro-Leu) (7), was isolated from the culture broth of Streptomyces sp. BM-8, an actinobacterial strain isolated from the feces of Equus quagga. The structures of these compounds were established by analyses of spectroscopic data, including 1D and 2D NMR spectra (NMR), as well as by HR-ESI-MS spectrometry and chem. derivative analyses. Addnl., a serial analog of nonactic acid and homononacticacid (8-21) was synthesized. The cytotoxicity of 1-21 wastested against a panel of cancer cell lines, such as HT-29, MCF-7, A375 and K562, with MTT assay. In addition, the cytotoxicity tests revealed that 1 was less cytotoxic toward a panel of cancerous cells, as compared with valinomycin (6).

Molecules published new progress about Colon neoplasm. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Synthetic Route of 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Yu, Shui; Zhu, Yuan-Xing; Peng, Cheng; Li, Jiyang published the artcile< Two new sterol derivatives isolated from the endophytic fungus Aspergillus tubingensis YP-2>, Formula: C11H18N2O2, the main research area is ergosterimide sterol derivative endophyte fungus Aspergillus; Aspergillus tubingensis; cytotoxicities; demethylincisterol A5; endophytic fungus; ergosterimide B; secondary metabolites.

Two new sterol derivatives, namely ergosterimide B (1) and demethylincisterol A5 (2), along with eleven known metabolites (3-13), were isolated from the rice fermentation culture of Aspergillus tubingensis YP-2. The chem. structures were elucidated by detailed NMR and MS spectroscopic data and by comparison with reported data. Newly isolated compound and known compound were evaluated for their cytotoxicities against the A549 and HepG2 cell lines. Compound showed weak activities with IC50 values of 11.05 and 19.15μM, resp., while exhibited cytotoxicities with IC50 values of 5.34 and 12.03μM, resp., against the tested cell lines.

Natural Product Research published new progress about Cytotoxicity. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Formula: C11H18N2O2.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Yang, Jian; Zhao, Binbin; Qian, Li; Gao, Fengjie; Fan, Yanjuan; He, Xiaoyan; Ma, Qingyan; Yang, Lihong; Yan, Bin; Wang, Wei; Ma, Xiancang published the artcile< Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study>, Formula: C11H18N2O2, the main research area is genetically determined metabolite human intelligence metabolic pathway; 5-Oxoproline; Genetically determined metabolite; Human intelligence; Mendelian randomization; Metabolic pathway.

Intelligence predicts important life and health outcomes, but the biol. mechanisms underlying differences in intelligence are not yet understood. The use of genetically determined metabotypes (GDMs) to understand the role of genetic and environmental factors, and their interactions, in human complex traits has been recently proposed. However, this strategy has not been applied to human intelligence. Here we implemented a two-sample Mendelian randomization (MR) anal. using GDMs to assess the causal relationships between genetically determined metabolites and human intelligence. The standard inverse-variance weighted (IVW) method was used for the primary MR anal. and three addnl. MR methods (MR-Egger, weighted median, and MR-PRESSO) were used for sensitivity analyses. Using 25 genetic variants as instrumental variables (IVs), our study found that 5-oxoproline was associated with better performance in human intelligence tests (PIVW = 9.25 x 10-5). The causal relationship was robust when sensitivity analyses were applied (PMR-Egger = 0.0001, PWeighted median = 6.29 x 10-6, PMR-PRESSO = 0.0007), and repeated anal. yielded consistent result (PIVW = 0.0087). Similarly, also dihomo-linoleate (20:2n6) and p-acetamidophenylglucuronide showed robust association with intelligence. Our study provides novel insight by integrating genomics and metabolomics to estimate causal effects of genetically determined metabolites on human intelligence, which help to understanding of the biol. mechanisms related to human intelligence.

Molecular Brain published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (AACSP1). 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Formula: C11H18N2O2.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Huang, Pan; Yu, Leilei; Tian, Fengwei; Zhao, Jianxin; Zhang, Hao; Chen, Wei; Zhai, Qixiao published the artcile< Untargeted metabolomics revealed the key metabolites in milk fermented with starter cultures containing Lactobacillus plantarum CCFM8610>, Electric Literature of 2873-36-1, the main research area is milk fermentation lactobacillus plantarum culture metabolite metabolomics.

This study employed untargeted metabolomics to reveal the metabolic changes in fermented milk during storage. According to the sparse partial least squares-discriminant anal. (sPLS-DA), Lactobacillus plantarum CCFM8610 was confirmed to be critical for the metabolic profile of fermented milk. Five of the forty-three metabolites, namely benzoic acid, 6-hydroxycaproic acid, D-phenyllactic acid, hippuric acid, and N-oleoylethanolamine, were identified as the key metabolites related to L. plantarum CCFM8610. This study illustrated that L. plantarum CCFM8610, as a probiotic and co-cultivated starter culture, was critical for the functional properties and preservative qualities of fermented milk during storage. Overall, these metabolites had potential impact on the storage properties and physiol. functions of fermented milk, which provides a valuable reference for improving the quality of fermented milk products.

LWT–Food Science and Technology published new progress about Fermentation. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Electric Literature of 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Cardenas, Paco; Gamage, Jayani; Hettiarachchi, Chamari M.; Gunasekera, Sunithi published the artcile< Good Practices in Sponge Natural Product Studies: Revising Vouchers with Isomalabaricane Triterpenes>, HPLC of Formula: 2873-36-1, the main research area is isomalabaricane triterpene sponge natural product; Porifera; Rhabdastrella globostellata; chemotaxonomy; isomalabaricane triterpenes; misidentification; vouchers.

Species misidentification in the field of natural products is an acknowledged problem. These errors are especially widespread in sponge studies, albeit rarely assessed and documented. As a case study, we aim to revisit reports of isomalabaricane triterpenes, isolated from four demosponge genera: Jaspis, Geodia, Stelletta and Rhabdastrella. From a total of 44 articles (1981-2022), 27 unique vouchers were listed, 21 of which were accessed and re-examined here: 11 (52.4%) of these were misidentified. Overall, 65.9% of the studies published an incorrect species name: previously identified Jaspis and Stelletta species were all in fact Rhabdastrella globostellata. We conclude that isomalabaricane triterpenes were isolated from only two Rhabdastrella species and possibly one Geodia species. In addition to shedding a new light on the distribution of isomalabaricane triterpenes, this study is an opportunity to highlight the crucial importance of vouchers in natural product studies. Doing so, we discuss the impact of species misidentification and poor accessibility of vouchers in the field of sponge natural products. We advocate for stricter voucher guidelines in natural product journals and propose a common protocol of good practice, in the hope of reducing misidentifications in sponge studies, ensure reproducibility of studies, and facilitate follow-up work on the original material.

Marine Drugs published new progress about Fatty acids, Me esters Role: PAC (Pharmacological Activity), BIOL (Biological Study) (Globostellatic acid). 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, HPLC of Formula: 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Leyte-Lugo, Martha; Richomme, Pascal; Poupard, Pascal; Pena-Rodriguez, Luis M. published the artcile< Identification and quantification of a phytotoxic metabolite from Alternaria dauci>, Reference of 2873-36-1, the main research area is Daucus carota Alternaria dauci phytotoxic metabolite quantification; Alternaria leaf blight; Daucus carota; p-hydroxybenzoic acid; phytotoxins; α-acetylorcinol.

Alternaria dauci is the causal agent of Alternaria leaf blight (ALB) in carrot (Daucus carota) crops around the world. However, to date, A. dauci has received limited attention in its production of phytotoxic metabolites. In this investigation, the bioassay-guided isolation of the extract from liquid cultures of A. dauci resulted in the isolation of two metabolites identified as α-acetylorcinol (1) and p-hydroxybenzoic acid (2), based on their spectroscopic data and results from chem. correlation reactions. Testing of both metabolites in different assays showed an important phytotoxic activity for p-hydroxybenzoic acid (2) when tested in the leaf-spot assay on parsley (Petroselinum crispum), in the leaf infiltration assay on tobacco (Nicotiana alata) and marigold (Tagetes erecta), and in the immersion assay on parsley and parsnip (Pastinaca sativa) leaves. Quantification of the two metabolites in the crude extract of A. dauci kept at different times showed that p-hydroxybenzoic acid (2) is one of the first metabolites to be synthesized by the pathogen, suggesting that this salicylic acid derivative could play an important role in the pathogenicity of the fungus.

Molecules published new progress about Alternaria dauci. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Reference of 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Meng, Lili; Sun, Changli; Zhang, Chunyan; Song, Shihao; Sun, Xiuyun; Ju, Jianhua; Deng, Yinyue published the artcile< Efficacy of compounds isolated from Streptomyces olivaceus against the morphogenesis and virulence of Candida albicans>, Computed Properties of 2873-36-1, the main research area is Streptomyces Candida morphogenesis virulence; Candida albicans; Streptomyces olivaceus; hypha formation; virulence.

Candida albicans is a type of commensal fungi which causes serious infections in immunocompromised patients and contributes to high mortality. In the present study, we identified that the extract from Streptomyces olivaceus SCSIO T05 inhibited hypha and biofilm formation of C. albicans. Seven compounds were isolated and evaluated for their effects on the biol. functions and virulence of C. albicans. Two leading compounds, compound 1 (sorbicillin) and compound 2 (3-methyl-N-(2′-phenethyl)-butyrylamide) were identified as exhibiting strong activity against C. albicans morphol. transition, adhesion activity, cytotoxicity, and adhesion to human cells, in a dose-dependent manner. Notably, compound 2 inhibited C. albicans infection in mouse oral mucosal models. Transcriptomic anal. and real-time PCR results revealed that compound 2 most likely inhibited the biol. functions of C. albicans cells by regulating the expression levels of HWP1, TEC1, ALS1, IFD6, and CSH1, which are associated with filament formation and cell adhesion. Our results suggest that the candidate compounds present excellent efficacy against C. albicans pathogenicity and that they can be developed as potential options for the clin. treatment of candidiasis.

Marine Drugs published new progress about Agglutinin-like protein 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Computed Properties of 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Jiang, Qingjian; Wei, Nan; Huo, Yishen; Kang, Xi; Chen, Gang; Wen, Lu published the artcile< Secondary Metabolites of the Endophytic Fungus Cladosporium sp. CYC38>, Reference of 2873-36-1, the main research area is cerevisterol beta sitosterol Cyclosorus Cladosporium Salmonella.

This study of Cyclosorus parasiticus plant affected by Cladoporium fungi organism. Fungi secondary metabolites of cerevisterol, cyclo-gly-phe. these compounds are act as a antibacterial activity. Cyclo-pro–N-MePhe-Val-Ala-Leu is against microorganism like Salmonella sp, Escherichia coli, staphylococcus.

Chemistry of Natural Compounds published new progress about Cladosporium. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Reference of 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem