Related Products of 28217-95-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28217-95-0 name is 2-Benzylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step B – Synthesis of 1 -phenyl-] -(2-pyrazinyl)-bromomethaneTo a solution of 2-benzylpyrazine (100 mg, 0.59 mmol) in 5 mL acetonitrile was added l,3-dibromo-5,5-dimethylhydantoin (183 mg, 0.64 mmol) and the reaction was heated at 65 C for 3 days. The solvent was evaporated and the crude product was purified using preparative TLC (20% acetone in hexane) to provide 2-(l-bromophenylmethyl)-pyrazine (50 mg, 35% yield) which was used immediately for the next step.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Benzylpyrazine, and friends who are interested can also refer to it.
Reference:
Patent; SCHERING CORPORATION; WO2008/130581; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem