Category: 27825-21-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 27825-21-4

[577] Step A: 3-mercapto-pyrazine-2-carboxylic acid methyl ester [578] After 3-chloro-pyrazine-2-carboxylic acid methyl ester (0.4 g, 2.3 mmol)was dissolved in MeOH (46 mL), sodium hydrosulfide monohydrate (0.65 g, 6.9mmol) was added thereto, and the mixture was stirred at room temperature for 9hours. After the termination of the reaction, the reactant was concentratedunder reduced pressure, and 1N HCl aqueous solution was used to adjust the pHof the reactant to 3. The reactant was extracted with EtOAc, and the organiclayer was separated to obtain the title compound (0.35 g, 89%).[579] 1H-NMR (CDCl3) delta 8.43(1H, m), 8.42(1H, m),5.18(1H, brs), 4.04(3H, s)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 27825-21-4.

Reference:
Patent; LG LIFE SCIENCES LTD.; KIM, Young Kwan; KIM, Myoung Yeol; PARK, Sang Yun; PARK, Ok Ku; ARTEMOV, Vasily; LEE, Sang Dae; JOO, Hyun Woo; CHOI, Eun Sil; WO2014/69963; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 3-chloropyrazine-2-carboxylate

Step 2: Methyl 3-(pyridin-2-yl)pyrazine-2-carboxylate (Y2) To a solution of the product from step 1 (100 mg, 0.58 mmol) in toluene (2 mL) was added Pd(PPh3)4 (134 mg, 0.12 mmol) and 2-(tributylstannyl)pyridine (213 mg, 0.58 mmol) at room temperature and the resulting mixture was heated to 100 C overnight. After cooled to RT, the mixture was filtered and 5 mL of aq. KF solution was added to the filtrate. The resulting mixture was stirred for 30 mins and extracted with EtOAc (5 mL x 3). The combined organic layers were washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by chromatography (30% EtOAc in petroleum ether) to provide the title compound. LRMS m/z (M+H) 216.1 found, 216.1 required.

The synthetic route of 27825-21-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KIM, Ronald; KUDUK, Scott, D.; LIVERTON, Nigel; ZHUO, Gang; (116 pag.)WO2016/100161; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H5ClN2O2

EXAMPLE II-23 In 15 mL of acetonitrile was dissolved 0.3 g of methyl 3-chloro-2-pyrazinecarboxylate. At an ice-cooled temperature, 10% fluorine gas (a fluorine gas diluted with nitrogen gas) was introduced at a rate of 45 ml per minute for a period of 18 minutes. Then, while elevating the temperature from the ice-cooled temperature to room temperature, nitrogen gas was introduced for one hour, and the reaction product was concentrated under reduced pressure. The oily product thus obtained was purified by silica gel column chromatography (eluent: n-hexane:ethyl acetate=10:1] to obtain 0.03 g of methyl 3-chloro-6-fluoro-2-pyrazinecarboxylate as a colorless oily product. IR (neat) cm-1: 1736 1H-NMR (CDCl3) delta: 4.04(3H,s), 8.43(1H,d,J=8.3 Hz)

According to the analysis of related databases, 27825-21-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 27825-21-4, The chemical industry reduces the impact on the environment during synthesis 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.

The mixture of 1.35 g (7.8 mmol, 1 eq.) of 3-chloro-2-pyrazine methyl carboxylate prepared in example 20a), 0.7 ml (7.8 mmol, 1 eq.) of methyl thioglycolate and 1.62 g (11.7 mmol, 1.5 eq.) of K2CO3 in 60 ml of acetonitrile is heated under stirring for 16 hrs. The solvent is concentrated and immersed in 200 ml of water. After acidifying with 1N HCl, extraction is performed 3 times with CH2Cl2, the organic phase is dried on Na2CO3, filtered and evaporated. 1.21 g (73.5%) of aromatized product is obtained. FP=188 C. NMR (1H, DMSO): 2.50 (s; 3H; SCH3), 3.87 (s; OCH3), 8.81 (d, J=2.3 Hz; 1H, arom. H), 8.86 (d, J=2.3 Hz; 1H; arom. H), 11.67 (m; 1H; OH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-chloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Imbert, Thierry; Monse, Barbara; Koek, Wouter; US2005/80085; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 27825-21-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

A solution of methyl 3-chloropyrazine-2-carboxylate (200.0 mg, 1.15 mmol, CAS 27825-21-4), (i?)-/V-[(3ri)-l,3-dihydrospiro[indene-2,4′-piperidin]-3-yl]-2-methylpropane-2- sulfmamide (772.0 mg, 1.26 mmol, 50% purity) and CsF (522.0 mg, 3.44 mmol) in DMSO (15.0 mL) was stirred at 60 C for 1 hour. The reaction mixture was poured into H20 (60.0 mL) and extracted with EtOAc (60.0 mL x 2). The combined organic layers were washed with brine (40.0 mL), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to give an orange residue. The residue was purified by flash silica gel chromatography (12 g column, ethyl acetate in petroleum ether from 0% to 65%) to give methyl 3-[(3ri)-3-{[(i?)-2-methylpropane-2-sulfmyl]amino}-l,3-dihydrospiro[indene-2,4′- piperidin]-l’-yl]pyrazine-2-carboxylate (450.0 mg, 89% yield) as a yellow oil. LCMS m/z [M+H]+= 443.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-chloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; TAYLOR, Alexander, M.; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; WALTERS, W., Patrick; MURCKO, Mark, Andrew; MCLEAN, Thomas, H.; GUNAYDIN, Hakan; GIORDANETTO, Fabrizio; THERRIEN, Eric; (607 pag.)WO2019/183367; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H5ClN2O2

To a solution of the product from step 1 (100 mg, 0.58 mmoi) in toluene (2 mL) was added Pd(PPh3)4 (134 mg, 0.12 mmol) and 2ttributylstannyl)pyridine (213 mg, 0,58 mrnol) at room temperature and the resulting mixture heated to 100 C overnight. After cooling to RI, the mixture was filtered and 5 rnL of aq. KF solution was added to the filtrate. The resulting mixture was stirred for 30 mins and extracted with EtOAc (5 mL x3). The combined organic layerswere washed with brine, dried over Na2504, filtered and concentrated in vacuo, The residue was purified by chromatography (30% EtOAc in petroleum ether) to provide the title compound as a oil. LRMS nih (M-f-H) 216.1 found, 216,1 required.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 27825-21-4.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; SKUDLAREK, Jason; (79 pag.)WO2016/95204; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 27825-21-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Methyl 3-chloropyrazine-2-carboxylate (504 mg, 2.9 mmol, 1 eq.), O-benzylhydroxylamine (1073 mg, 8.72 mmol, 3 eq.), Dimethyl sulfoxide (3 mL) and N,N-diisopropylethylamine (1.44 mL, 8.72 mmol, 3 eq.) were added to a microwave reaction tube, and microwave reaction was performed at 100 C for one hour. After the reaction, the reaction solution was transferred to a separating funnel, 30 mL of ethyl acetate and 30 mL of a saturated sodium chloride solution were added, the organic phase was separated, and the aqueous layer was extracted twice with ethyl acetate. The organic phases were combined, dried over anhydrous magnesium sulfate, filtered, and the filtrate was concentrated and sampled with 100-200 mesh silica gel. After purification by 200-300 mesh silica gel column chromatography (eluent EA: PE = 1: 4), crude intermediate 2 was obtained. The crude product was recrystallized from petroleum ether / n-hexane to obtain intermediate 3-((benzyloxy)amino)pyrazine-2-carboxylic acid methyl ester (2, yield: 16%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-chloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shandong University; Liu Xinyong; Sun Lin; Zhan Peng; Gao Ping; Cheng Xiqiang; Li Yanqi; Wang Xueshun; (24 pag.)CN108299428; (2019); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: Methyl 3-chloropyrazine-2-carboxylate

Example 15. Production of methyl 3-trifluoromethyl-pyrazine-2-carboxylate (compound No. 3-4) Methyl 3-chloropyrazine-2-carboxylate (2 g, 11.6 mmol), cuprous iodide (3.3 g, 17.3 mmol), potassium fluoride (1.34 g, 23 mmol) and methyl chlorodifluoroacetate (3.36 g, 18.2 mmol) were dissolved in DMF (20 ml) and stirred at 115C for 5 hours under argon atmosphere. The reaction solution was filtered with celite, followed by dilution of the filtrate with ethyl acetate, and washing four times with water. The filtrate was dried over magnesium sulfate, and concentrated under reduced pressure, and then the residue was purified by using silica gel chromatography (hexane:ethyl acetate=3:1) to obtain 700 mg of the desired compound as paste state. Yield: 29% Property: 1H-NMR [CDCl3/TMS, delta (ppm)] 8.85 (d, 1H), 8.83(d, 1H), 4.05(s,3H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 27825-21-4, its application will become more common.

Reference:
Patent; NIHON NOHYAKU CO., LTD.; EP1757595; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 27825-21-4, A common heterocyclic compound, 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 16 3-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]pyrazine-2-carboxylic acid methyl ester dihydrochloride Grams 20.5 of 1-(2,3-dihydroxypropyl)piperazine and 11 g of 3-chloropyrazine-2-carboxylic acid methyl ester in 100 ml dioxane were refluxed for one hour. The reaction mixture was cooled and settled, the solvent evaporated and the obtained residue dissolved in concentrated hydrochloric acid and the solution diluted with isopropanol until incipient precipitation. After resting, 12.7 g of 3-[4-(2,3-dihydroxypropyl)piperazin-1-yl]pyrazine-2-carboxylic acid methyl ester dihydrochloride melting at 195-197C (with decomposition), were obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DOMPE’ FARMACEUTICI S.p.A.; EP230402; (1993); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 27825-21-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

A solution of 17.4 ml (0.184 mmol, 2.8 eq.) of ethyl glycolate in 20 ml of DME is added drop by drop to a suspension of 6.85 g (0.171 mol, 2.6 eq.) of NaH (60% in oil) at 0 C. in 200 ml of DME. After leaving under stirring for 15 min, 11.36 g of the chlorinated derivative from step a) above in solution in 20ml of DME is then introduced. After returning to a normal temperature, the medium is heated to 80 C. for 9 hrs. After evaporation and resuspension in water, the medium is acidified with acetic acid to pH 4 and then extracted with 5 times 50 ml of ethyl acetate. After drying on Na2So4, filtration and evaporation, the residue is triturated in petroleum ether and then crystallized, filtered and vacuum dried. 9.91 g (72%) of aromatization product is obtained. FP=160 C. (dec). NMR (1H, CDCl3): 1.48 (t; J=7.2 Hz; 3H; CH3 ester), 4.53 (q; J=7.2 Hz; 2H; CH2 ester), 8.41 (m; 1H; OH), 8.50 (d, J=2.4 Hz; 1H; arom. H), 8.69 (d, J=2.4 Hz; 1H; arom. H).

The synthetic route of Methyl 3-chloropyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Imbert, Thierry; Monse, Barbara; Koek, Wouter; US2005/80085; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem