In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 274-45-3, name is Pyrrolo[1,2-a]pyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Quality Control of Pyrrolo[1,2-a]pyrazine
PREPARATION EXAMPLE 13 Preparation of 6-and 8-chloropyrrolo-[1,2-a]pyrazine 3.6 g of pyrrolo[1,2-a]pyrazine prepared in Preparation Example 1 was dissolved in a mixture of 20 ml of dimethyl sulfoxide and 20 ml of ethyl acetate; and 4.8 g of N-chloro succinimide was added thereto. The reaction mixture was stirred at 60 C. for 6 hours, poured into ice-water, extracted with ethyl acetate(100 ml*3), and then concentrated under a reduced pressure. The residue was chromatographed over silica gel to obtain 0.6 g of 6-chloropyrrolo[1,2-a]pyrazine and 0.4 g of 8-chloropyrrolo[1,2-a]pyrazine, respectively.
The synthetic route of 274-45-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yuhan Corporation; US5593984; (1997); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem