Category: 2727-13-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2727-13-1, name is 3-Amino-6-chloropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Computed Properties of C5H4ClN3O2

To a mixture of 3-amino-6-chloropyrazine-2-carboxylic acid (1 .00 g; 5.76 mmol) and triethylamine (2.40 ml; 17.3 mmol) in abs. DMF is added 2-tert-butyl-5-methyl-1 ,2-oxazol-2- ium hexafluoro-phosphate (4.93 g; 17.3 mmol). The mixture is stirred at r.t. over night. Ice- water is added. The supernatant is decanted from the resin-like product which is sufficiently pure to be further reactedESI Mass spectrum: m/z = 313 [M+H]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KLEY, Joerg; HAERLE, Daniel; LINZ, Guenter; STEHLE, Sandra; WO2013/64451; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 2727-13-1, A common heterocyclic compound, 2727-13-1, name is 3-Amino-6-chloropyrazine-2-carboxylic acid, molecular formula is C5H4ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 3-amino-6-chloro-pyrazine-2-carbox-ylic acid (26.0 mg; 0.150 mmol), the amine intermediateIX.3 (100 mg; 0.151 mmol), TETU (53.0 mg; 0.165 mmol),triethylamine (63.2 jtl; 0.450 mmol) and DMF (5.0 ml) isstirred at tt. overnight. Volatiles are evaporated and theresidue is purified by RP-HPLC (Cl 8; water-ACN-TFA).10130] C25H33C1N7O5SxC2O2F3 ESI Mass spectrum_mlz=590 [M+H]+10131] HPLC analytics: RT=0.42 mm (HPLC method D)

The synthetic route of 2727-13-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Boehringer Ingelheim International GmbH; HECKEL, Armin; HAMPRECHT, Dieter; KLEY, Joerg; WIEDENMAYER, Dieter; (29 pag.)US2017/50992; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 2727-13-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2727-13-1, name is 3-Amino-6-chloropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

DIPEA (200 muIota, 1.15 mmol) was added to a solution of 3-amino-6-chloropyrazine-2- carboxylic acid (50 mg, 0.29 mmol), 2-(aminomethyl)-1-ethyl-6-methoxy-3-methyl-1H-1 ,3- benzodiazol-3-ium iodide, Intermediate 13 (100 mg, 0.29 mmol) and HBTU (142 mg, 0.37 mmol) in anhydrous DMF (1 ml). The resulting mixture was stirred at ambient temperature for 18 h. The reaction mixture was concentrated under a flow of nitrogen to afford the crude product as an oil. The crude material was purified by flash column chromatography on C18 (12 g). The column was eluted with MeCN:H20 + 0.1 % formic acid using the following gradient (%MeCN, column volumes): 10%, 2 CV; 10-100%, 20 CV; 100%, 2 CV. The desired fractions were combined and lyophilised to yield the product as an off-white solid (84 mg, 58%).1H NMR (250 MHz, DMSO-de) delta 9.57 (t, J = 5.3 Hz, 1 H), 8.38 (s, 1 H), 7.93 (d, J = 9.1 Hz, 1 H), 7.66 (s, 2H), 7.57 (d, J = 2.2 Hz, 1 H), 7.29 (dd, J = 9.1 , 2.3 Hz, 1 H), 4.99 (d, J = 5.3 Hz, 2H), 4.62 (q, J = 7.0 Hz, 2H), 4.09 (s, 3H), 3.91 (s, 3H), 1.38 (t, J = 7.1 Hz, 3H). LC/MS (System C): m/z (ESI+) = 375 [M(35CI)+], 377 [M(37CI)+]), R = 1.83 min, UV purity = 100%.

The chemical industry reduces the impact on the environment during synthesis 3-Amino-6-chloropyrazine-2-carboxylic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ENTERPRISE THERAPEUTICS LIMITED; MCCARTHY, Clive; HARGRAVE, Jonathan David; HAY, Duncan Alexander; SCHOFIELD, Thomas Beauregard; WENT, Naomi; (111 pag.)WO2017/221008; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 2727-13-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2727-13-1, name is 3-Amino-6-chloropyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To a mixture of 3-amino-6-chloropyrazine-2-carboxylic acid (1.00 g; 5.76 mmol) and triethylamine (2.40 ml; 17.3 mmol) in abs. DMF is added 2-tert-butyl-5-methyl-1,2-oxazol-2-ium hexafluoro-phosphate (4.93 g; 17.3 mmol). The mixture is stirred at r.t. over night. Ice-water is added. The supernatant is decanted from the resin-like product which is sufficiently pure to be further reacted (C13H17ClN4O3) ESI Mass spectrum: m/z=313 [M+H]+

The synthetic route of 3-Amino-6-chloropyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

The chemical industry reduces the impact on the environment during synthesis 2727-13-1, name is 3-Amino-6-chloropyrazine-2-carboxylic acid, I believe this compound will play a more active role in future production and life. 2727-13-1

A mixture of 3-amino-6-chloro-pyrazine-2-carboxylic acid (26.0 mg; 0.150 mmol), the amineintermediate IX.3 (100 mg; 0.15 1 mmol), TBTU (53.0 mg; 0.165 mmol), triethylamine (63.2 tl;0.450 mmol) and DMF (5.0 ml) is stirred at r.t. over night. Volatiles are evaporated and the residue is purified by RP-HPLC (C 18; water-ACN-TFA).C26H33C1N705S x C202F3 ESI Mass spectrum: mlz = 590 [M+H]+HPLC analytics: RT = 0.42 mm (HPLC method D)

The chemical industry reduces the impact on the environment during synthesis 2727-13-1. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HECKEL, Armin; FRATTINI, Sara; HAMPRECHT, Dieter; KLEY, Joerg; WIEDENMAYER, Dieter; (49 pag.)WO2017/28927; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem