Category: 25513-92-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25513-92-2, name is Ethyl 3-methylpyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Formula: C8H10N2O2

A mixture of 3-methyl-pyrazine-2-carboxylic acid ethyl ester (2.5 g, 15.04 mmol), N-bromosuccinimide also referred to herein as NBS (5.5 g, 30.8 mmol), and azobisisobutyronitrile also referred to herein as AIBN (0.12 g, 0.75 mmol) in carbon tetrachloride (50 ml) was stirred and refluxed for 48 h, cooled to room temperature, filtered and washed with CCI4. The filtrate was evaporated and the crude residue purified by FC chromatography eluting with 15% ethylacetate/ cyclohexane to give the desired product as a pale yellow solid (1 .64 g)1H-NMR (CDCI3): 8.71 (d, 1 H), 8.68 (d, 1 H), 5.1 (s, 2H), 4.58 (q, 2H), 1 .44 (t, 3H)

The synthetic route of 25513-92-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; REINGRUBER, Ruediger; KRAUS, Helmut; HUTZLER, Johannes; NEWTON, Trevor, William; WITSCHEL, Matthias; MOBERG, William, Karl; PARRA RAPADO, Liliana; BESONG, Gilbert; RACK, Michael; KLOET, Andree van der; SEITZ, Thomas; LERCHL, Jens; KREUZ, Klaus; GROSSMANN, Klaus; EVANS, Richard, Roger; WO2012/85265; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25513-92-2 as follows. Application In Synthesis of Ethyl 3-methylpyrazine-2-carboxylate

Example 1.3: Preparation of 3-bromomethyl-pyrazine-2-carboxylic acid ethyl esterA mixture of 3-methyl-pyrazine-2-carboxylic acid ethyl ester (Example 1.1) (0.5 g), N-bromosuccinimide (“NuBS”) (0.536 g) and 2,2′-azobis(2-methylpropionitrile) (“AIBNu”) (0.487 g) in carbon tetrachloride (2.5 ml) was heated to reflux. After 1 hour thin layer chromatography showed a mixture of starting material and the desired product. Further NuBS (0.536 g) and AIBNu (0.243 g) were added and the reaction mixture heated for a further 1 hour. The percentage of product increased and impurities began to form. The reaction mixture was cooled to ambient temperature and then to 0C. The cold mixture was filtered and the filtrate concentrated. The residue was purified by chromatography on silica gel(eluent: 0-10% v/v ethyl acetate in zso-hexane) to give 3-bromomethyl-pyrazine-2-carboxylic acid ethyl ester (640 mg) contaminated with 3-methyl-pyrazine-2-carboxylic acid ethyl ester (due to co-elution, -3:2). MH+ – 245, RT = 1.26 min (Method A).

According to the analysis of related databases, 25513-92-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNGENTA LIMITED; WILLETTS, Nigel, James; MULHOLLAND, Nicholas, Phillip; WORTHINGTON, Paul, Anthony; AVERY, Alaric, James; WO2010/130970; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem