2423-65-6 Archives

8-Sep-21 News Discovery of 2423-65-6

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2423-65-6, name is Pyrazine 1-oxide, A new synthetic method of this compound is introduced below., Computed Properties of C4H4N2O

General Procedure 2:; Palladium-Catalyzed Direct Arylation with Aryl Chlorides and Bromides.; To a dried flask was added the diazine N-oxide (1.0 to 3.0 equiv.), K2CO3 (2.0 equiv.), Pd(OAc)2 (5 mol %) and HP(t-Bu)3BF4 (15 mol %). If the arylhalide is a solid, it is added at this point (1.0 equiv.). The flask and its contents were then purged under nitrogen for 10 minutes. If the aryl halide is a liquid, it is added via syringe after purging, followed by the addition of degassed dioxane (to produce a reaction concentration of 0.3 M relative to the halide). The reaction mixture was then heated at 110 C. until the reaction was complete, after which the volatiles were removed under reduced pressure and the residue was purified via silica gel column chromatography.; 2-p-Tolylpyrazine N-oxide (81) Synthesised according to general procedure 2 employing the corresponding aryl bromide and chloride or 60 with the corresponding aryl iodide. Purification via silica gel column chromatography using 100% DCM then a mixture of 20% Acetone/DCM gave a white solid, 72% (from the bromide), 75% (from the chloride) and 77% (from the iodide). 1H NMR (300 MHz, CDCl3, 293K, TMS): delta 8.63 (1H, s), 8.37 (1H, s), 8.20 (1H, s), 7.72 (2H, d, J=8.1 Hz), 7.33 (2H, d, J=7.8 Hz), 2.43 (3H, s). 13C NMR (75 MHz, CDCl3, 293K, TMS): 148.2, 145.2, 144.6, 140.8, 134.2, 129.8, 129.0, 125.9, 21.5.

Reference:
Patent; University of Ottawa; US2008/132698; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Simple exploration of 2423-65-6

Application of 2423-65-6, A common heterocyclic compound, 2423-65-6, name is Pyrazine 1-oxide, molecular formula is C4H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Synthesis of meso-substituted calixarenes 4a-f (general procedure). A 1.6 M solution of BunLi in hexane (1.44 mL, 2.3 mmol) was added to a vigorously stirred solution of TMEDA (0.43 mL, 2.9 mmol) in anhydrous THF (4 mL) cooled to -78 C. After 40 min of stirring, a solution of 25,26,27,28-tetramethoxycalix[4]arene (480.5 mg, 1.0 mmol) in anhydrous THF (5 mL) was added, the reaction mixture was warmed up to room temperatures and stirred for another 2 h. The solution of formed 2-lithium-25,26,27,28-tetramethoxycalix[4]arene (1) was cooled to -78 C, and a solution of the corresponding azine N-oxide 2a-f (2.0 mmol) in anhydrous THF (6 mL) was added. The reaction mixture was stirred at room temperature for 1 h, followed by the addition of AcCl (0.14 mL, 2.0 mmol). The mixture was concentrated at reduced pressure. The residue was subjected to column chromatography on SiO2, the eluate was concentrated dry in vacuo.

Reference:
Article; Varaksin; Chupakhin; Charushin; Khlamkin; Utepova; Russian Chemical Bulletin; vol. 64; 5; (2015); p. 1093 – 1096; Izv. Akad. Nauk, Ser. Khim.; 5; (2015); p. 1093 – 1096,4;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Research on new synthetic routes about 2423-65-6

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazine 1-oxide, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 2423-65-6, name is Pyrazine 1-oxide, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2423-65-6, Formula: C4H4N2O

Conditions: The N-oxide (2 equiv.), aryl halide, Pd(OAc)2 (5 mol %), Pt-Bu3-HBF4 (15 mol %), K2CO3 (2 equiv.) and the additive (if indicated, 2 equiv.) were added to a round bottom flask followed by the addition of dioxane and heating to 110 C.; Initial reaction screens with N-oxides 60, 70 and 80 under previously described conditions lead to disappointing results, probably due to the fact that the N-oxides were only sparingly soluble in toluene. The reaction conditions were reinvestigated. These efforts lead to the discovery that dioxane provides superior conversions with N-oxides 60 and 80 giving the cross coupled products 81 and 82 in 75% and 72% yields respectively (Table 3, entries 1 and 2). These two substrates actually exhibit superior reactivity compared to pyridine N-oxide as demonstrated by a competition experiment between 80 and pyridine N-oxide which results in exclusive arylation of 60 (Table 3, entry 4). In contrast to the excellent results obtained with 60 and 80, pyrimidine N-oxide 70 reacts in low yield (Table 3, entry 3).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazine 1-oxide, and friends who are interested can also refer to it.

Reference:
Patent; University of Ottawa; US2008/132698; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

A new synthetic route of Pyrazine 1-oxide

The synthetic route of Pyrazine 1-oxide has been constantly updated, and we look forward to future research findings.

Reference of 2423-65-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2423-65-6, name is Pyrazine 1-oxide belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General Procedure 2:; Palladium-Catalyzed Direct Arylation with Aryl Chlorides and Bromides.; To a dried flask was added the diazine N-oxide (1.0 to 3.0 equiv.), K2CO3 (2.0 equiv.), Pd(OAc)2 (5 mol %) and HP(t-Bu)3BF4 (15 mol %). If the arylhalide is a solid, it is added at this point (1.0 equiv.). The flask and its contents were then purged under nitrogen for 10 minutes. If the aryl halide is a liquid, it is added via syringe after purging, followed by the addition of degassed dioxane (to produce a reaction concentration of 0.3 M relative to the halide). The reaction mixture was then heated at 110 C. until the reaction was complete, after which the volatiles were removed under reduced pressure and the residue was purified via silica gel column chromatography.; 2-(Naphthalen-1-yl)pyrazine N-oxide (Table 4, entries 2, 13 and 14) Synthesised according to general procedure 2 employing the corresponding aryl bromide and chloride. Purification via silica gel column chromatography using 100% DCM then a mixture of 10% Acetone/DCM gave a brown oil, 89% from the bromide and 60% from the chloride. 1H NMR (300 MHz, CDCl3, 293K, TMS): delta 8.61 (1H, s), 8.48 (1H, d, J=3.9 Hz), 8.26 (1H, d, J=4.2 Hz), 8.00 (1H, d, J=7.8 Hz), 7.93-7.87 (1H, m), 7.59-7.37 (5H, m). 13C NMR (75 MHz, CDCl3, 293K, TMS): 150.1, 147.1, 145.7, 134.8, 133.9, 131.5, 131.3, 129.2, 128.9, 127.6, 127.0, 125.7, 125.3. HRMS calculated for C14H10N2O1 (M+) 222.0793; Found: 222.0775. IR (vmax/cm-1): 3057, 3010, 2923, 2853, 1578, 1301, 873, 801, 776.

The synthetic route of Pyrazine 1-oxide has been constantly updated, and we look forward to future research findings.

Discovery of Pyrazine 1-oxide

Related Products of 2423-65-6, A common heterocyclic compound, 2423-65-6, name is Pyrazine 1-oxide, molecular formula is C4H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference:
Patent; University of Ottawa; US2008/132698; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The important role of Pyrazine 1-oxide

The synthetic route of Pyrazine 1-oxide has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 2423-65-6, name is Pyrazine 1-oxide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: Pyrazine 1-oxide

The synthetic route of Pyrazine 1-oxide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; University of Ottawa; US2008/132698; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Discovery of Pyrazine 1-oxide

Reference:
Patent; University of Ottawa; US2008/132698; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Discovery of Pyrazine 1-oxide

The synthetic route of 2423-65-6 has been constantly updated, and we look forward to future research findings.

2423-65-6, name is Pyrazine 1-oxide, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C4H4N2O

Preparation 28 2-Amino-6-cyanopyrazine This intermediate was prepared via a stepwise procedure. A mixture of 21 g. of pyrazine-2-carboxamide, 85 ml. of glacial acetic acid, and 75 ml. of 30 percent hydrogen peroxide was heated at about 55¡ã C. for about 35 hours. The reaction product mixture was cooled and filtered. The solid which was collected was extracted with n-butanol and the extracts discarded. The solid which was insoluble in n-butanol was recrystallized from hot water to yield a white solid having a melting point of about 302¡ã-305¡ã C. The solid was identified by elemental analyses as pyrazine-2-carboxamide 4-oxide. To a mixture of 4 g. of the pyrazine oxide (prepared above) in 40 ml. of dimethylformamide cooled in an ice bath, there was quickly added 12 ml. of phosphorus oxychloride. The reaction mixture was poured into water and the aqueous mixture extracted with ethyl acetate, and the extracts saved. Additional water was added to the aqueous layer and the aqueous mixture extracted with hexane-ether. The ethyl acetate and hexane-ether extracts were combined and concentrated in vacuo to leave a residue. The residue was identified by elemental analyses and IR spectrum as 2-chloro-6-cyanopyrazine, and was used without further purification in the next step. A mixture of 1 g. of the above chlorocyanopyrazine and 25 ml. of dimethyl sulfoxide was prepared and anhydrous ammonia was bubbled thereinto. The reaction mixture was stirred overnight and then poured into water. The aqueous mixture was extracted with ethyl acetate, and the extracts dried. The drying agent was filtered off and the solvent removed in vacuo to leave a solid which was identified by its IR spectrum as 2-amino-6-cyanopyrazine. It was used as is without further purification in the preparation of final products of the invention.

The synthetic route of 2423-65-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eli Lilly and Company; US4293552; (1981); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Brief introduction of Pyrazine 1-oxide

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2423-65-6, its application will become more common.

Some common heterocyclic compound, 2423-65-6, name is Pyrazine 1-oxide, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 2423-65-6

General Procedure 2:; Palladium-Catalyzed Direct Arylation with Aryl Chlorides and Bromides.; To a dried flask was added the diazine N-oxide (1.0 to 3.0 equiv.), K2CO3 (2.0 equiv.), Pd(OAc)2 (5 mol %) and HP(t-Bu)3BF4 (15 mol %). If the arylhalide is a solid, it is added at this point (1.0 equiv.). The flask and its contents were then purged under nitrogen for 10 minutes. If the aryl halide is a liquid, it is added via syringe after purging, followed by the addition of degassed dioxane (to produce a reaction concentration of 0.3 M relative to the halide). The reaction mixture was then heated at 110 C. until the reaction was complete, after which the volatiles were removed under reduced pressure and the residue was purified via silica gel column chromatography.2-Mesitylpyrazine N-oxide (Table 4, Entry 5) Synthesised according to general procedure 2. Purification via silica gel column chromatography using 100% DCM then a mixture of 15% Acetone/DCM gave a beige solid 70% yield with 2 eq. of the N-oxide and 76% yield with 3 eq. of the N-oxide. 1H NMR (300 MHz, CDCl3, 293K, TMS): delta 8.45 (1H, d, J=3.9 Hz) 8.42 (1H, s), 8.26 (1H, d, J=4.2 Hz), 7.00 (2H, s), 2.34 (3H, s), 2.07 (6H, s). 13C NMR (75 MHz, CDCl3, 293K, TMS): 149.4, 146.2, 145.3, 140.0, 137.2, 134.3, 128.5, 125.7, 21.1, 19.4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2423-65-6, its application will become more common.

Reference:
Patent; University of Ottawa; US2008/132698; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Continuously updated synthesis method about Pyrazine 1-oxide

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazine 1-oxide, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 2423-65-6, The chemical industry reduces the impact on the environment during synthesis 2423-65-6, name is Pyrazine 1-oxide, I believe this compound will play a more active role in future production and life.

1) Take 0.25mmol of pyrazine nitrogen oxide,diphenyl disulfide 0.45mmol,Cu(AcO)2 0.125 mmol and potassium hydroxide 0.5 mmol,add 1 mL of toluene to make a mixture,the mixture was placed in a 5 ml Schlenk tube,heated in an oil bath at 130C,after 48 hours of reaction,cool to room temperature to obtain the reaction solution;2) Concentrate the reaction solution to obtain a concentrate, and use a mixed solvent of ethyl acetate and petroleum ether in a volume ratio of 1:3 as a developing agent, and use silica gel as an adsorbent to perform thin layer chromatography to obtain 16 mg of the target product. The target product yield of this example is 32%, and the target product is subjected to nuclear magnetic characterization.

Reference:
Patent; Henan Agricultural University; Wu Zhiyong; Zhao Mingqin; Lai Miao; (13 pag.)CN108017581; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem