Category: 23611-75-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 23611-75-8, name is Methyl 6-chloropyrazine-2-carboxylate belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. 23611-75-8

A solution of 6-chloro-pyrazine-2-carboxylic acid methyl ester (690 mg, 4.0 mmol, l eq), Me6Sn2 (1.0 mL, 4.82 mmol, 1.2 eq) and Pd(PPh3)4 (231 mg, 0.20 mmol, 0.05 eq) in toluene (20 mL) was heated at 80 C for 12 h under nitrogen atmosphere. The mixture was cooled to rt and was concentrated. The residue was purified by chromatography on a silica gel column (EAJ PE = 1/5) to give 6-trimethylstannanyl-pyrazine-2-carboxylic acid methyl ester (360 mg, 30%) as a yellow oil.

The synthetic route of 23611-75-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; WO2015/103317; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

A common heterocyclic compound, 23611-75-8, name is Methyl 6-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 23611-75-8.

Add methyl 6-chloropyrazine-2-carboxylate (20. 0 g, 116 mmol) in THF (1 00 mL) to methylmagnesium bromide (3.0 mol/L) in diethyl ether (120 g, 348 mmol, 3.0 mol/L) at 0 C and the mixture is stirred at this temperature for 2 h. The reaction is quenched with 1.0HCl solution (100 mL) and extracted with EtOAc (100 mL x 3). The combined organic layers are washed with brine (100 mL), dried over anhydrous sodium sulfate, concentrated to afford a yellow oil. The yellow oil is purified by column chromatography on silica gel eluting with 0-30% EA in PE to afford title compound (3.80 g, 18.0%) as brown oil. LCMS (m/z): 5 172.8 [M+H]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 6-chloropyrazine-2-carboxylate, its application will become more common.

Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; MA, Tianwei; WU, Liang; ZHANG, Xuejun; (109 pag.)WO2019/41340; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem