Category: 22047-25-2

22047-25-2, Name is Acetylpyrazine, molecular formula is C6H6N2O, belongs to Pyrazines compound, is a common compound. In a patnet, author is Arar, Sharif, once mentioned the new application about 22047-25-2, Name: Acetylpyrazine.

New forced degradation products of vildagliptin: Identification and structural elucidation using LC-MS, with proposed formation mechanisms

A new and simple RP-HPLC-UV method was developed for well-separation of vildagliptin raw material and its degradation products at different conditions; it uses of ammonium acetate buffer at pH= 7.5 and methanol with Athena C18 -WP (250 mm) column. Results show that six degradants have been identified using LC-MS technique, in addition to the NMR approach in some cases. One degradant at relative retention time (RRT) 1.3 was formed under acidic condition and designated as 2-((1R, 3S, 5R, 7S)-3-hydroxyadamantan-1-yl) hexahydropyrrolo[1,2-a]pyrazine-1,4-dione at m/z = 304. Three degradants were formed under various conditions of basic hydrolysis at RRTs 1.2, 0.6 and 0.4 with following names and molar masses (m/z), respectively: 1-(((1S, 3S, 5S, 7S)-1,3-dihydroxyadamantan-2-yl)glycyl)pyrrolidine-2-carboxamide at m/z = 337.2, 1-(((1R, 3S, 5R, 7S)-3-hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carboxamide at m/z = 321.1 and (1,4-dioxo-1,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3-yl)glycylproline at m/z = 322.6. Another three degradants were also formed under oxidative oxidations of vildagliptin, one at RRT 0.38 and designated as N-hydroxy-N-((1R, 3S, 5R, 7S)-3-hydroxyadamantan-1-yl) glycinate with m/z 241.1, the second one was identical to that formed under basic hydrolysis at RRT 0.6 and the last one has RRT 0.8 and was identified as (1S, 3R, 5R, 7S)-3-(hydroxyamino)adamantan-1-ol at m/z 183.1. Formation mechanisms for the degradation products were described.

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Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 22047-25-2, Name is Acetylpyrazine, molecular formula is C6H6N2O, belongs to Pyrazines compound. In a document, author is Zhang, Bing, introduce the new discover, HPLC of Formula: C6H6N2O.

Planarized intramolecular charge transfer on triphenylamine-modified pyrazine and its application in organic light-emitting diodes

Excellent luminescence and transportation are the most essential features of organic light-emitting diodes (OLEDs); however, many D-A type materials usually facilitate charge transport but have poor luminescence properties. Herein, we designed two triphenylamine-pyrazine compounds, namely 25-TPA2P and 26-TPA2P, with planarized intramolecular charge transfer character to overcome this problem. Both single crystal XRD and computational analysis show an asymmetric configuration for 26-TPA2P, which furnishes 26-TPA2P with relatively strong ICT and better charge transport balance, as compared with the symmetric 25-TPA2P. A non-doped device containing 25-TPA2P displays sky-blue electroluminescence with a maximum external quantum efficiency (eta(ext)) of 6.09%, by virtue of its strong emission in the solid state and its orientation; for 26-TPA2P, a deep blue OLED with a CIEy of 0.07 and eta(ext) of 4.88% is achieved. Thanks to the balanced transport ability of 26-TPA2P, a series of high efficiency orange/red phosphorescent OLEDs and two-color hybrid WOLEDs are obtained based on 26-TPA2P as the host material. The eta(ext) of the orange OLED exceeds 28%, and the warm-white OLED exhibits a total eta(ext) of 30.11%. These results suggest that PLICT materials could satisfy both conditions of good charge transportation and luminescence, which could bring about bright prospects for displays and illuminations.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 22047-25-2. HPLC of Formula: C6H6N2O.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 22047-25-2, Name is Acetylpyrazine, formurla is C6H6N2O. In a document, author is Tan, Xinyi, introducing its new discovery. Quality Control of Acetylpyrazine.

An insight into volatile and non-volatile compounds of Chinese horsebean-chili-paste meju produced by natural brewing and temperature-controlled brewing methods

BACKGROUND Chinese horsebean-chili-paste (CHCP) is a traditional fermented condiment in China, known as ‘the soul of Sichuan cuisine’. The horsebean-to-meju phase in its preparation is important for CHCP production and contributes significantly to its taste and odor. In this study, a comprehensive flavor compound profiling analysis of the naturally brewed horsebean meju (NBHM) and the temperature-controlled brewed horsebean meju (TCBHM) was performed with two-dimensional gas chromatography time-of-flight mass spectrometry (GC x GC-TOFMS), and the analysis of physicochemical characteristics and free amino acids. Their aroma-active components and characteristic flavor compounds were evaluated. The flavor compounds responsible for differentiating NBHM and TCBHM were also determined based on the Fisher ratio and principal component analysis. RESULTS The pH and the reducing sugar and amino-acid nitrogen content of NBHM were 5.38, 64.43, and 5.76 g kg(-1), respectively, whereas those of TCBHM were 5.13, 29.20, and 7.43 g kg(-1). A total of 356 volatiles were identified from 2571 compounds, and 257 volatile compounds were identified in NBHM compared to 322 volatiles in TCBHM. These two horsebean mejus (HMs) exhibited a similar proportion profile for 30 aroma-active compounds. Benzoic acid ethyl ester, 4-ethyl-2-methoxy-phenol and argnine were determined to be characteristic flavor components for NBHM, while 1-(2-furanyl)-ethanone, 2,6-dimethyl-pyrazine, threonine, valine and tyrosine were specific to TCBHM. CONCLUSION Temperature-controlled brewed horsebean meju possessed better physicochemical and flavor characteristics than NBHM. The temperature-controlled brewing technique in CHCP production can be used as a promising alternative to the traditional natural brewing method. (c) 2020 Society of Chemical Industry

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 22047-25-2, Name is Acetylpyrazine, molecular formula is C6H6N2O. In an article, author is Chen, Ming,once mentioned of 22047-25-2, Application In Synthesis of Acetylpyrazine.

Evoking Photothermy by Capturing Intramolecular Bond Stretching Vibration-Induced Dark-State Energy

Development of highly effective approaches to desirable photothermal conversion agents is particularly valuable. Herein, we report a concept, namely, bond stretching vibration-induced photothermy, that serves as a mechanism to construct advanced photothermal conversion agents. As a proof-of-concept, two compounds (DCP-TPA and DCP-PTPA) with donor-acceptor (D-A) structures were synthesized. The bond stretching vibration of the pyrazine-containing unit in these molecules is vigorous and insensitive to the external environmental restraint, which efficiently transforms the absorbed photons to dark-state heat energy. The nanoparticles (NPs) of DCP-TPA and DCPPTPA show rather high photothermal conversion efficiency (52% and 59%) and stronger photoacoustic (PA) signal than commercial methylene blue and reported high-performance semiconducting polymer nanoparticles. The DCP-PTPA NPs perform better than DCP-TPA NPs in terms of photothermal conversion, PA signal production, and in vivo PA tumor imaging because of the increased bond stretching vibration in the former molecule.

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Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 22047-25-2, Name is Acetylpyrazine, molecular formula is C6H6N2O, belongs to Pyrazines compound. In a document, author is Wang, Si-Qing, introduce the new discover, HPLC of Formula: C6H6N2O.

Copper(I)-Catalyzed Asymmetric Vinylogous Aldol-Type Reaction of Allylazaarenes

A vinylogous aldol-type reaction of allylazaarenes and aldehydes is disclosed that affords a series of chiral gamma-hydroxyl-alpha,beta-unsaturated azaarenes in moderate to excellent yields with high to excellent regio- and enantioselectivities. With (R,R-P)-TANIAPHOS and (R,R)-QUINOXP* as the ligand, the carbon-carbon double bond in the products is generated in (E)-form. With (R)-DTBM-SEGPHOS as the ligand, (Z)-form carbon-carbon double bond is formed in the major product. In this vinylogous reaction, aromatic, alpha,beta-unsaturated, and aliphatic aldehydes are competent substrates. Moreover, a variety of azaarenes, such as pyrimidine, pyridine, pyrazine, quinoline, quinoxaline, quinazoline, and benzo[d]imidazole are well-tolerated. At last, the chiral vinylogous product is demonstrated as a suitable Michael acceptor towards CuI-catalyzed nucleophilic addition with organomagnesium reagents.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 22047-25-2. HPLC of Formula: C6H6N2O.

Related Products of 22047-25-2, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 22047-25-2, Name is Acetylpyrazine, SMILES is C1=C(N=CC=N1)C(=O)C, belongs to Pyrazines compound. In a article, author is Monroe, Jeffrey C., introduce new discover of the category.

Well-isolated pyrazine-bridged copper(II) chains: synthesis and magneto-structural analysis

A pair of well-isolated 1-D-QHAF compounds with the molecular formula [Cu(pz)(L)(2)(H2O)(2)](ClO4)(2)with L = 3-Cl-4-hydroxypyridine (1) and 3-Br-4-hydroxypyridine (2) (catena-(diaqua-bis(3-chloro/bromo-4-pyridono-kappa O)(mu-pyrazine)copper(II) diperchlorate) were synthesized via slow-evaporation crystallization and characterized structurally and magnetically to develop magneto-structural correlations. Single-crystal X-ray diffraction at 120 K provided the structures of1and2which comprise six-coordinate Cu(II) pyrazine-bridged chains propagating parallel to the crystallographica-axis in the triclinic space-groupP-1. Chains are offset from each other in thec-direction by the bulk of L and along the d(z2)axis occupied by a semi-coordinate water molecule engaged in hydrogen bonding with the perchlorate gegenion. Magnetic susceptibility experiments showed that1and2behave as quasi-Heisenberg 1-D-AFMs withJ approximate to 8 K and no sign of 3 D ordering down to 1.8 K. Aspects of crystal engineering are addressed to understand the potential to design systems with desired magnetic properties in light of comparisons with a variety of pyrazine-bridged chains already in the literature. The effect of L and the general structural scaffold are investigated to this end. Powder X-Band EPR experiments were performed to determine the electronic environment of the Cu(II) ion and average g-factor. The pyrazine-bridged chains in1with the AFM electronic spins represented as glowing arrows.

Related Products of 22047-25-2, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 22047-25-2 is helpful to your research.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 22047-25-2, Name is Acetylpyrazine, SMILES is C1=C(N=CC=N1)C(=O)C, in an article , author is Wu, Wen-Kui, once mentioned of 22047-25-2, Category: Pyrazines.

Multifunctional Zinc Metal-Organic Framework for Highly Selective Detection of Picric Acid and Inhibition of Laryngeal Cancer Cell Growth

A new rigid and symmetrical tetracarboxylic ligand 2,3,5,6-tetrakis(4-carboxyphenyl)pyrazine (H4TCPP) ligand was employed in the construction of a new Zn(II)-based metal-organic framework [Zn-3(OH)(2)(H2TCPP)(2)](DMF)(3) (1). Complex 1 not only displays bright blue luminescence arising from the matrix coordination-induced emission effect of the TCPP2- ligand, but also exhibits effective detection for picric acid in the solution with the quenching constant of 3.59 x 10(4) M-1. In the biological study, we investigated the effect of compound on Hep laryngeal cancer cell viability and proliferation with CCK8 assay, analyzed the production of autophagy in Hep cells by flow cytometer, and the western blot was also used to detect the expression of autophagy-related proteins. Moreover, the autophagy inhibitor 3-MA was used in this study to explore the role of autophagy in the anti-cancer activity of compound.

Interested yet? Read on for other articles about 22047-25-2, you can contact me at any time and look forward to more communication. Category: Pyrazines.

Application of 22047-25-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 22047-25-2, Name is Acetylpyrazine, SMILES is C1=C(N=CC=N1)C(=O)C, belongs to Pyrazines compound. In a article, author is Banerjee, Tanmay, introduce new discover of the category.

Holey Heterographenes Made to Order: Green” Synthesis of Porous Graphitic Frameworks

Fully annulated pyrazine-linked porous graphitic frameworks (PGFs) have garnered attention because of their potential applications in optoelectronics and energy storage. In this issue of Chem, Zhang, Liu, and co-workers report a base-promoted aqueous synthesis of such porous heterographenes with high crystallinity and application potential as cathodes in lithium-ion batteries.

Application of 22047-25-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 22047-25-2 is helpful to your research.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Wang, Shengqiang, once mentioned the application of 22047-25-2, Name is Acetylpyrazine, molecular formula is C6H6N2O, molecular weight is 122.1246, MDL number is MFCD00006134, category is Pyrazines. Now introduce a scientific discovery about this category, Category: Pyrazines.

Ag-catalyzed decarboxylative acylation of pyridazines using alpha-keto acids in aqueous media

An efficient and general protocol for Ag-Catalyzed decarboxylative acylation of pyridazines using alpha-keto acids as acylation reagent in aqueous media has been described. This method provides a new avenue for the synthesis of diverse array of acylated pyridazines with different substitution patterns. The reaction proceeds smoothly in water under mild conditions and exhibits a good functional group tolerance. (C) 2020 Elsevier Ltd. All rights reserved.

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Electric Literature of 22047-25-2, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 22047-25-2, Name is Acetylpyrazine, SMILES is C1=C(N=CC=N1)C(=O)C, belongs to Pyrazines compound. In a article, author is Xu, Su-Peng, introduce new discover of the category.

Zero/one-dimensional coordination complexes constructed from the carboxylate and multi-nitrogen chelating ligands: structural insights and photocatalytic degradation of organic dye

In the current study, two new coordination complexes with the chemical formulae of [Co(cbba)(bimb)](H2O) (1, H(2)cbba = 3-((3-carboxybenzyl)oxy)benzoic acid, bimb = 6,6 ‘-bis(1H-benzo[d]imidazol-2-yl)-2,2’-bipyridine) and {[Co(pdc)(bimb)](DMF)}(n) (2, H(2)pda = pyrazine-2,5-dicarboxylic acid) have been successfully prepared by reaction of the Co(NO3)(2)center dot 6H(2)O with the bimb ligand in the presence of different carboxylate ligands (H(2)cbba for 1 and H(2)pda for 2). The as-prepared two complexes have been determined via the elemental analysis, single crystal X-ray diffraction along with the powder X-ray diffraction. In addition, the photocatalytic activity of complex 2 toward the degradation of methyl violet (MV) in simulated polluted water was explored.

Electric Literature of 22047-25-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 22047-25-2.