Category: 22047-25-2

Synthetic Route of 22047-25-2, The chemical industry reduces the impact on the environment during synthesis 22047-25-2, name is Acetylpyrazine, I believe this compound will play a more active role in future production and life.

A solution of 5.4 g (40 mmol) 1-Pyrazin-2yl-ethanone in 21 ml HBr (33%) and 7 ml methanol was treated with 2.05 ml (40 mmol) bromine and heated to 60 C. for 7 h.The precipitate was filtered off, washed with ethyl acetate/diethyl ether 1/1 and dried to obtain 8.3 g (55%) of the title compound as grey solid. 1-H-NMR (400 MHz, DMSO-d6) delta=8.78 (d, J=2 Hz, 1H, H-5), 8.66 ((d, J=2 Hz, 1H, H-6), 5.01 (s, 2H, CH2), 2.75 (s, 3H, CH3). MS (m/e): 215.0 (M+H, 100%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Acetylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Mattei, Patrizio; Neidhart, Werner; Nettekoven, Matthias Heinrich; Pflieger, Philippe; Taylor, Sven; US2003/225141; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 22047-25-2, A common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, molecular formula is C6H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A stirred solution of 1-(pyrazin-2-yl)ethanone (1.24 g, 0.01 mol) in methanol (20 ml) was added dropwise to a solution of 4-chloro-6-hydrazinylpyrimidine (1.44 g,0.01 mol) in methanol (30 ml) plus three drops of glacial acetic acid. The mixture was refluxed for 4 h and then cooled to room temperature. The precipitated solid was filtered off and washed with cold methanol to obtain a white solid. Yield: 86.3 %. 1H NMR (400 MHz, DMSO) d ppm: 11.16 (s, 1H), 8.62-8.53 (m, 5H), 9.46 (s, 1H), 7.48(s, 1H), 2.40 (s, 3H). (Fig. S1). 13C NMR (100 MHz,DMSO) dppm: 162.94, 159.80, 158.21, 150.26, 148.14,143.83, 143.13, 142.63, 102.99, 11.91. (Fig. S2). ESI-MS (DMF, positive ion mode): m/z = 249.07([M + H]+), C10H9ClN6 theoretical mass: 248. (Fig. S3). IR/cm-1(KBr):1565 (s), 1369 (m), 3150 (m), 3438 (m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Hasi, Qi-Meige; Fan, Yan; Feng, Xiao-Xia; Yao, Xiao-Qiang; Liu, Jia-Cheng; Transition Metal Chemistry; vol. 41; 6; (2016); p. 685 – 692;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 22047-25-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 22047-25-2, Name is Acetylpyrazine, SMILES is C1=C(N=CC=N1)C(=O)C, belongs to Pyrazines compound. In a article, author is Yan, Jin-Long, introduce new discover of the category.

Crystal structure of diethanol-kappa O-1-bis(mu(2)-N-((2-oxidonaphthalen-1-yl)methylene)pyrazine-2-carbohydrazonato-kappa N-5,O,O ‘:O ‘:N ‘)-bis(nitrato-kappa O-2,O ‘)dieuropium(III), C36H32N10O12Eu2

C36H32N10O12Eu2, monoclinic, C2/c (no. 15), a = 16.445(2) angstrom, b = 10.0920(14) angstrom, c = 23.865(3) angstrom, beta = 100.115(8)degrees, V = 3899.3(9) angstrom(3), Z = 4, Rgt(F) = 0.0687, wR(ref)(F-2) = 0.2065, T = 150(2) K.

Application of 22047-25-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 22047-25-2 is helpful to your research.

Chemistry is an experimental science, Recommanded Product: 22047-25-2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 22047-25-2, Name is Acetylpyrazine, molecular formula is C6H6N2O, belongs to Pyrazines compound. In a document, author is Zhang, Huaizhi.

The Biosynthesis Mechanism Involving 2,3-Pentanedione and Aminoacetone Describes the Production of 2-Ethyl-3,5-dimethylpyrazine and 2-Ethyl-3,6-dimethylpyrazine by Bacillus subtilis

2-Ethyl-3,5(3,6)-dimethylpyrazines (EDMPs) have a pleasant aroma of roasted cocoa or nuts with an extreme low odor threshold that have potential in industrial applications as food fragrances. The food fermentation process can accumulate EDMPs, and this might be the chance to study the biosynthesis mechanism of EDMPs under mild conditions for natural EDMPs’ production. In this study, an EDMP-producing strain was isolated from baijiu fermentation. This strain was identified as Bacillus subtilis, a generally regarded as safe organism. After reasonable assumption and substrate addition and isotope-labeled experiments, we found that EDMPs are produced from L-threonine and n-glucose at environmental temperature and pressure. In addition, aminoacetone, the metabolite of L-threonine, and 2,3-pentanedione, the metabolite of L-threonine and ID-glucose, are intermediates for the production of EDMPs. This study proposed and confirmed the biosynthesis pathway of EDMPs. It will be helpful for the industrial production of EDMPs and provides reference for the biosynthetic mechanism analysis of other valuable pyrazines.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 22047-25-2. Recommanded Product: 22047-25-2.

Let¡¯s face it, organic chemistry can seem difficult to learn, Recommanded Product: 22047-25-2, Especially from a beginner¡¯s point of view. Like 22047-25-2, Name is Acetylpyrazine, molecular formula is Pyrazines, belongs to Pyrazines compound. In a document, author is Glisic, Biljana D., introducing its new discovery.

Mononuclear gold(iii) complexes with diazanaphthalenes: the influence of the position of nitrogen atoms in the aromatic rings on the complex crystalline properties

A series of mononuclear gold(iii) complexes of the general formula [AuCl3(diazanaphthalene)], where diazanaphthalene is quinazoline (qz, 1), phthalazine (phtz, 2), 1,5-naphthyridine (1,5-naph, 3), 1,6-naphthyridine (1,6-naph, 4) or 1,8-naphthyridine (1,8-naph, 5), were prepared and fully characterized. The complexes 1-5 consist of discrete monomeric species with the Au(iii) cation in a square planar coordination geometry surrounded by three chloride anions and one diazanaphthalene ligand. Crystallographic studies indicate the presence of an extended 4 + 1 or 4 + 2 geometry around the square planar [AuCl3(diazanaphthalene)] center due to AuMIDLINE HORIZONTAL ELLIPSISCl and AuMIDLINE HORIZONTAL ELLIPSISN interactions. The crystal structures of these complexes are controlled by a variety of intermolecular interactions that utilize the amphiphilic properties of the coordinated chloride anions and involve C-H groups, pi-electrons, and an uncoordinated nitrogen atom of the diazanaphthalene ligand. The usual offset pi-stacking between the N-heteroaromatic ligands appears to be completely hindered between the 1,5-naph fragments and significantly weakened between the 1,6-naph and 1,8-naph in their respective complexes 3, 4 and 5, for which the average molecular polarizability (alpha) values are the lowest in the series. It is remarkable that the [AuCl3(benzodiazine)] complexes 1 and 2 form centrosymmetric crystals, but the [AuCl3(naphthyridine)] complexes 3-5 assemble into non-centrosymmetric aggregates, making them potential alternatives to the previously studied systems for application in various fields by taking advantage of their polarity.

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In an article, author is Karaaslan, Cigdem, once mentioned the application of 22047-25-2, COA of Formula: C6H6N2O, Name is Acetylpyrazine, molecular formula is C6H6N2O, molecular weight is 122.1246, MDL number is MFCD00006134, category is Pyrazines. Now introduce a scientific discovery about this category.

Regioselective N-alkylation of some imidazole-containing heterocycles and their in vitro anticancer evaluation

Imidazole-containing heterocycles: Imidazopyridines, imidazopyrimidines and imidazopyra-zines can exist more tautomeric forms than benzimidazoles. Their regioselectivities were determined for N-alkylations with 4-fluorobenzyl bromide under basic conditions (K2CO3) in DMF. We observed that, regioisomers were mainly formed as a mixture in this reaction and N-benzylation occurs at a higher ratio on six membered heterocycles. Their structural assignments were made with the use of two-dimensional H-1-H-1 NOE (nuclear overhauser effect spectroscopy, NOESY). Complementary structural informationwas provided by 2D-HMBC spectra of the compounds. Synthesized compounds were tested for in vitro cytotoxic activities against Human colon cancer cell line (HCT-116) and leukemia cell lines (K562 and HL-60) by MTT test. Among them, imidazopyridine analogue 10, bearing bromine atom at the C-6 position of the pyridine moiety, gave the lowest IC50 value with 6-7 mu g/mL against all three cancer cell lines. (C) 2020 Elsevier B.V. All rights reserved.

If you are interested in 22047-25-2, you can contact me at any time and look forward to more communication. COA of Formula: C6H6N2O.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 22047-25-2, Name is Acetylpyrazine, SMILES is C1=C(N=CC=N1)C(=O)C, in an article , author is Pan, Lei, once mentioned of 22047-25-2, Recommanded Product: Acetylpyrazine.

Oxidative Ring-Opening of 1H-Pyrazol-5-amines and Its Application in Constructing Pyrazolo-Pyrrolo-Pyrazine Scaffolds by Domino Cyclization

Herein, an oxidative ring-opening of 1H-pyrazol-5-amines to form 3-diazenylacrylonitrile derivatives under mild and transition-metal-free conditions is described. In addition, the nucleophilic addition of deprotonated 1H-pyrrole-2-carbaldehydes to the vinyl moiety of the yielded 3-diazenylacrylonitriles could trigger domino cyclization to afford the 3H-pyrazolo[3,4-e]pyrrolo[1,2-a]pyrazine derivatives. Computational studies suggest that the oxidation of 1H-pyrazol-5-amines in the presence of PhIO is through the formation of a hydroxylamine intermediate followed by elimination of H2O to result in the ring-opening product. The detailed domino cyclization pathway leading to the pyrazolo-pyrrolo-pyrazine scaffolds is revealed.

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 22047-25-2, Name is Acetylpyrazine, molecular formula is C6H6N2O. In an article, author is Khavasi, Hamid Reza,once mentioned of 22047-25-2, Safety of Acetylpyrazine.

Complementary Features of Inorganic (M-X) and Organic (C-X ‘) Halogens in C-X ‘center dot center dot center dot X-M Halogen Bonds: A Study Based on Structure, Energy, and Topological Electron Density

A family of 10 compounds, each containing a MX2-pyrazine carboxylate complex anion and a protonated halo- (X’-) amino pyridine cation (MX2 = ZnCl2, ZnBr2, ZnI2, HgBr2, and HgI2; X’ = Cl, Br, I), are presented; a suitable system for pursuing C-X’center dot center dot center dot X-M halogen bonding (XB). The influence of halogen manipulation, metal ion and coordination variation on the nature and strength of C-X’center dot center dot center dot X-M interactions was discussed in terms of geometrical parameters, binding energies and charge density analysis with emphasis on the Laplacian of the electron density, del(2)rho. Interplay of XBs with other noncovalent interactions, mainly N-H center dot center dot center dot XM and N-py-H+center dot center dot center dot O- bonds, in supramolecular assemblies, were also investigated. The C-X’center dot center dot center dot X-M and N-H center dot center dot center dot X-M bonds have rationally been modified in strength upon changing the halogens involved, leading to systematic variations in the crystal packing.

Interested yet? Keep reading other articles of 22047-25-2, you can contact me at any time and look forward to more communication. Safety of Acetylpyrazine.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 22047-25-2, Name is Acetylpyrazine, SMILES is C1=C(N=CC=N1)C(=O)C, belongs to Pyrazines compound. In a document, author is Bera, Pradip, introduce the new discover, Category: Pyrazines.

Induced apoptosis against U937 cancer cells by Fe(II), Co(III) and Ni(II) complexes with a pyrazine-thiazole ligand: Synthesis, structure and biological evaluation

Complexes of iron(II), cobalt(III) and nickel(II) with 4-(4-methoxyphenyl)-2-(2-(1-(pyrazin-2yl)ethylidene)hydrazinyl)thiazole (PyztH) have been synthesized and characterized by elemental analyses, spectroscopic methods, CV measurements and a DFT study. The crystal and molecular structures were determined by the X-ray diffraction method. The complexes have the compositions [Fe(Pyzt)(2)]Br-2 (1), [Co(Pyzt)(2)]PF6 (2) and [Ni(Pyzt)(PyztH)IClO4 (3), with an approximate octahedral environment around the metal centre with NNN donor atoms from the two coordinating ligands. The complexes belong to the triclinic crystal system and crystallize in the space group P-1. Complex 1 is stabilized by strong hydrogen bonds, whereas the stability of complexes 2 and 3 is associated to pi-pi stacking interactions. The chemical reactivity, frontier orbital picture and energies of the HOMO and LUMO of the complexes have been estimated by a DFT study. The complexes are redox active species and respond with a quasi-reversible redox process. The cytotoxicity of the complexes was tested against U-937 human monocytic cells and shows IC50 values of 132 (for 1), 45 (for 2) and 162 mu M (for 3). A LDH release assay indicates that 2 and 3 show apoptosis in the tumour cell. Complex 2 induces apoptosis by disrupting the mitochondrial membrane potential and homeostasis leading to cytotoxicity, as envisaged by PARP cleavage. Complexes 1, 2 and 3 show high binding constants (2.01 x 10(6) M-1 for 1, 1.18 x 10(7) M-1 for 2 and 2.90 x 10(7) M-1 for 3) with CTDNA which attest the groove binding nature of the complexes with DNA. The compounds also exhibit a remarkable zone of inhibition against specific tested bacterial and fungal strains. Based on the results, the cobalt complex (2) shows the best antitumor and antimicrobial activity among the complexes under investigation. (C) 2020 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 22047-25-2 is helpful to your research. Category: Pyrazines.

Related Products of 22047-25-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 22047-25-2, Name is Acetylpyrazine, SMILES is C1=C(N=CC=N1)C(=O)C, belongs to Pyrazines compound. In a article, author is Liu, Junzhi, introduce new discover of the category.

Bottom-Up Synthesis of Nitrogen-Doped Polycyclic Aromatic Hydrocarbons

Bottom-up organic synthesis serves as an efficient method to provide atomically precise heteroatom-doped polycyclic aromatic hydrocarbons (PAHs) with not only well-defined size and edge structures but also specific concentrations and positions of the heteroatoms. We provide a plenary account of the preparation of nitrogen-doped PAHs (N-PAHs) through 1,3-dipolar cycloaddition between different dipolarophiles, as well as pyrazine-type N-doped diaza-hexa-peri-hexabenzocoronene (diaza-HBC). Additionally, we present the synthesis of a class of helical N-charged PAHs, including one charged aza[5]helicene and two charged aza[4]helicenes. Moreover, the bottom-up organic synthesis strategy is further extended to the construction of novel nitrogen-boron-nitrogen (NBN)-containing PAHs. Finally, we discuss the synthesis of four-coordinate boron chromophores containing 6,12,18-tris(alkyl amine)-5,11,17-triazatrinaphthylene derivative ligands. 1 Introduction 2 Nitrogen-Doped PAHs Based on Dibenzo-9a-azaphenalene (DBAP) 3 Cationic Nitrogen-Doped Helical PAHs 4 Nitrogen-Boron-Nitrogen-Doped PAHs 5 Conclusion and Outlook

Related Products of 22047-25-2, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 22047-25-2 is helpful to your research.