Category: 22047-25-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22047-25-2, name is Acetylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., name: Acetylpyrazine

A magnetic stirrer is added to the 250ml single-mouth eggplant bottle.Then add 1.85 g of p-bromobenzaldehyde, 2.44 g of 2-acetylpyrazine and 40 ml of ethanol.After stirring to completely dissolve, add 0.40 g of NaOH and 30 ml of concentrated ammonia water, and stir at room temperature for 6 hours.Filtration under reduced pressure, the filter cake was washed with ethanol and deionized water, and dried in vacuo to give Intermediate 4 as white solid, yield 1.75 g, yield 44.1%.The product was not further purified and the next reaction was carried out directly.

According to the analysis of related databases, 22047-25-2, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 22047-25-2, name is Acetylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22047-25-2, HPLC of Formula: C6H6N2O

General procedure: A 100 mL round-bottom flask charged with 2-acetylpyrazine (1.47 g, 2 mmol) was added MeOH (30 mL), KOH pellets (0.675 g,2 mmol) and water (2 mL). The resulting mixture was stirred for10 min and then added corresponding n,n?-dimethoxybenzaldehydes (1.0 g, 1 mmol) and ammonium solution (6 mL) was added slowly stirring at room temperature for 4 h, a white precipitate obtained was filtered, washed with MeOH and diethyl ether. The crude products on recrystallization in a mixture of CHCl3:MeOH (1:1) gave white crystals of desired compounds, 1-4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Acetylpyrazine, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 22047-25-2, name is Acetylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22047-25-2, Recommanded Product: Acetylpyrazine

According to a method based on literature [16], we made some modifications. 2-acetylpyrazine (1.22g, 10mmol) and 4-hydroxybenzohydrazide (1.52g, 10mmol) were mixed with 10mL of DMSO. The solution mixture was refluxed at 75C for 4h, and was after that cooled down, filtered, and washed with cold ethanol. Two grams of product (78% yield) were obtained by air-drying. MS, NMR, IR, and UV data are shown in the Supporting information (Section S1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Acetylpyrazine, other downstream synthetic routes, hurry up and to see.

Related Products of 22047-25-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22047-25-2, name is Acetylpyrazine, This compound has unique chemical properties. The synthetic route is as follows.

Step 1: Preparation of 4,4-difluoro-1-(2-pyrazinyl)-butane-1,3-dione Ethyl difluoroacetate (2.23 g, 18 mmol) was placed in a 100 mL round bottom flask and dissolved in ether (10 mL). To the stirred solution was added 25% sodium methoxide (4.68 g, 22 mmol) followed by acetylpyrazine (2.00 g, 16 mmol). After two hours stirring at room temperature, a precipitate formed and THF (10 mL) was added to the reaction. The reaction was stirred an additional 25.9 hours, then treated with 3N HCl (10 mL). The organic layer was collected, washed with brine (20 mL), dried over MgSO4, and concentrated in vacuo and recrystallized from methylene chloride/iso-octane to give the diketone as a brown solid (2.23 g, 68%); mp 103-110 C.; 1 H NMR (CDCl3) 300 MHz 14.00 (br s, 1H), 9.31 (d, J=1.4 Hz, 1H), 8.76 (d, J=2.4 Hz, 1H), 8.68 (dd, J=1.4 Hz 2.4 Hz, 1H), 7.20 (s, 1H), 6.03 (t, J=54.0 Hz, 1H); 19 F NMR (CDCl3) 300 MHz: -127.16 (d); M+ 200.

The chemical industry reduces the impact on the environment during synthesis Acetylpyrazine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; G.D. Searle & Co.; US5760068; (1998); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

22047-25-2, name is Acetylpyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C6H6N2O

Step A: 1-(Pyrazin-2-yl)ethylamine To a solution of 2-acetylpyrazine (206.7 mg, 1.7 mmol) and ammonium acetate (1.3 g, 17 mmol) in methanol (5.0 mL) was added sodium cyanoborohydride (75 mg, 1.19 mmol) followed by 3 A molecular sieves (0.85 g). The reaction mixture was stirred for 1 day at room temperature. It was acidified to pH 2 with concentrated HCl then filtered, and the solid was washed with methanol and H2O. The filtrate was concentrated in vacuo. The residue was dissolved in water and was made basic (pH 10-12) with 5N NaOH. The aqueous layer was extracted with CH2Cl2 several times while maintaining ~pH 10. The combined extracts were dried over Na2SO4, filtered, and concentrated the solvent in vacuo. The crude product was purified by preparative thin layer chromatography eluding with 5% 2M NH3 in MeOH/CH2Cl2 to give 74 mg of the title compound. 1H NMR (500 MHz, CDCl3): 8.61 (s, 1H); 8.5 (d, J=1.6 Hz, 1H); 8.44 (d, J=1.6 Hz, 1H); 4.21 (q, J=6.8 Hz, 1H); 1.46 (d, J=6.8 Hz).

The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck & Co., Inc.; US6498165; (2002); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 22047-25-2, These common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 1-(Pyrazin-2-yl)ethan-1-one or 1-(5-alkylpyrazin-2-yl)ethan-1-one (0.01 mol) and thecorresponding halogenated benzaldehyde (0.01 mol) were dissolved in pyridine (4.4 mL).Diethylamine (0.01 mol) was added, and the reaction mixture was stirred at 80-120 C for 1 h. Aftercooling, the mixture was poured into ice water (200 mL), acidified to pH 3 with a few drops of aceticacid, and then refrigerated for 24 h. The separation of crude products from water depended on theircharacter. Solids were filtered off and crystallized from anhydrous ethanol, while oily mixtures wereextracted with diethyl ether and subjected to flash chromatography on silica gel. Hexane-ethyl acetatewas used as the eluent in an appropriate ratio (70:30 (v/v), 80:20 (v/v) or 90:10 (v/v)). The fractionscontaining the desired compounds were combined and crystallized from absolute ethanol to obtainanalytically pure crystals.

The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kucerova-Chlupacova, Marta; Vyskovska-Tyllova, Veronika; Richterova-Finkova, Lenka; Kunes, Jiri; Buchta, Vladimir; Vejsova, Marcela; Paterova, Pavla; Semelkova, Lucia; Jandourek, Ondrej; Opletalova, Veronika; Molecules; vol. 21; 11; (2016);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, molecular formula is C6H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: Pyrazines

General procedure: A 100 mL round-bottom flask charged with 2-acetylpyrazine (1.47 g, 2 mmol) was added MeOH (30 mL), KOH pellets (0.675 g,2 mmol) and water (2 mL). The resulting mixture was stirred for10 min and then added corresponding n,n?-dimethoxybenzaldehydes (1.0 g, 1 mmol) and ammonium solution (6 mL) was added slowly stirring at room temperature for 4 h, a white precipitate obtained was filtered, washed with MeOH and diethyl ether. The crude products on recrystallization in a mixture of CHCl3:MeOH (1:1) gave white crystals of desired compounds, 1-4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 22047-25-2, its application will become more common.

Reference:
Article; Golla, Ramesh; Kumar, P. Raghavendra; Suchethan; Foro, Sabine; Nagaraju; Journal of Molecular Structure; vol. 1201; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 22047-25-2, A common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, molecular formula is C6H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

S (346 mg, 10.8mol) and morpholine (2 mL, 20 mmol) were added to a solution of 23 (664 mg, 5.4 mmol) and 24 (1 mL, 6.5 mmol) in t-BuOH (20 mL). The mixture was heated to 60 0C for 18 h. After evaporating t-BuOH, the residue was purified by column chromatography (PE/EtO Ac=I 00: 1) to give 25 (545 mg, 36 % yield).

The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CALCIMEDICA INC.; VELICELEBI, Gonul; STAUDERMAN, Kenneth A.; WHITTEN, Jeffrey P.; PEI, Yazhong; CAO, Jianguo; WANG, Zhijun; ROGERS, Evan; DYCK, Brian; GREY, Jonathan; WO2010/25295; (2010); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 22047-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22047-25-2, name is Acetylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of acetylpyrazine (0.041 g, 0.30 mmol) and ground 3 A dried molecular sieves in methanol was added dropwise 4,4’methyledianiline (0.029 g, 0.15 mmol) in methanol and a few drops of glacial acetic acid. The mixture was heated under reflux for 24 h. The molecular sieves were removed by filtration and the filtrate treated with FeCl2 4H2O (0.019 g, 0.10 mmol) and refluxed for 2 hours. The purple solution was treated with methanolic ammoniumhexafluorophosphate solution, the resulting precipitate were filtered off and dried over P4O10. recrystalization from CH3CN/diisopropylether afforded 0.052g, yield 58% of purple crystals of [Fe2L3](PF6) 1HNMR (300MHz, CD3CN, 298K) d = 9.68 (1H, br, H6/5) 8.82 (1H, br, H3), 7.37 (2H, br, H6/5, HPh), 6.77 (1H, d, J = 7.0 Hz, HPh), 6.77 (1H, d, J = 7.0 Hz, HPh), 4.65 (1H, d, J = 6.4 Hz, HPh), 4.04 (1H, s, CH2), 2.47 (3H, s, CH3).

The synthetic route of Acetylpyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY OF WARWICK; WO2005/33119; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 22047-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22047-25-2, name is Acetylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Step 1: Preparation of 4,4-difluoro-1-(2-pyrazinyl)-butane-1,3-dione Ethyl difluoroacetate (2.23 g, 18 mmol) was placed in a 100 mL round bottom flask and dissolved in ether (10 mL). To the stirred solution was added 25 weight % sodium methoxide (4.68 g, 22 mmol) followed by acetylpyrazine (2.00 g, 16 mmol). After two hours stirring at room temperature, a precipitate formed and THF (10 mL) was added to the reaction. The reaction was stirred an additional 25.9 hours, then treated with 3N HCl (10 mL). The organic layer was collected, washed with brine (20 mL), dried over MgSO4, and concentrated in vacuo and recrystallized from methylene chloride/isooctane to give the diketone as a brown solid (2.23 g, mp 103-110 C., 68%). 1 H NMR (CDCl3) 300 MHz 14.00 (br s, 1H), 9.31 (d, J=1.4 Hz, 1H), 8.76 (d, J=2.4 Hz, 1H), 8.68 (dd, J=1.4 Hz 2.4 Hz, 1H), 7.20 (s, 1H), 6.03 (t, J=54.0 Hz, 1H); 19 F NMR (CDCl3) 300 MHz: -127.16 (d); M+200.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Acetylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; G.D. Searle & Co.; US5466823; (1995); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem