Category: 22047-25-2

Application of 22047-25-2, The chemical industry reduces the impact on the environment during synthesis 22047-25-2, name is Acetylpyrazine, I believe this compound will play a more active role in future production and life.

(1) the isoniazid (1.64g, 12mmol), 2 – acetyl pyrazine (1.46g, 12mmol), 1.0 ml of formic acid is dissolved in 60 ml ethanol, reflux reaction 4h, cooling to room temperature, the generating precipitation filtering, cold washing with ethanol, to obtain white solid isoniazid compression acetyl pyrazine 2.75g, yield: 95%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Acetylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Qin, Jie; Ren, Qingling; Zhao, Shanshan; Liu, Yaping; Liu, Yanfei; Zhang, Keke; Zhu, Hailiang; (9 pag.)CN105061475; (2017); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 22047-25-2 as follows. Recommanded Product: 22047-25-2

The synthetic procedure used in this preparation is outlined below in Scheme D. To a solution of 1-pyrazin-2-yl-ethanone (2.0 g, 15.85 mmol) and ammonium acetate (19.337 g, 158.5 mmol) in methanol (50 mL) was added sodium cyanoborohydride (0.7 g, 11.1 mmol) in one portion. The reaction mixture was stirred overnight at room temperature. After removal of methanol, water (20 mL) was added to the residue and the resulting solution was basified by addition of sodium hydroxide to pH=13. The aqueous solution was extracted with dicholromethane and the combined organic phase was dried over sodium sulfate. Removal of the solvent under reduced pressure afforded 14.62 g of 1-pyrazin-2-yl-ethylamine, yield: 75%. MS (M+H)=124.

According to the analysis of related databases, 22047-25-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Broka, Chris Allen; Hawley, Ronald Charles; US2010/324056; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: Pyrazines

PZEH was synthesized by the condensation reaction of2-acetylpyrazine with hydrazine hydrate, with the loss of awater molecule. Hydrazine hydrate (0.1 ml, 2.05 mmol) wasadded to an ethanolic solution (10 ml) of 2-acetylpyrazine(0.251 g, 2.05 mmol). The solution was heated under reflux forabout 4 h with constant stirring and was then left to cool toroom temperature overnight to give a cream-coloured solid.The crude product was filtered off, dried in the air andrecrystallized from an EtOH/MeCN mixture to affordcolourless crystals that were suitable for X-ray diffraction. It isworth mentioning that PZEH will undergo further condensationto form the azine on standing at room temperature(yield 0.105 g, 37%; m.p. 394-395 K). Analysis calculated forC6H8N4 (%): C 52.93, H 5.92, N 41.15; found (%): C 52.95, H4.96, N 39.61; IR (cm1, KBr pellet): 3394 (s, N-H), 3318 (m,N-H), 3182 (s, aryl C-H), 2913 (m, alkyl C-H), 1657 (s,C N), 1592 (s, aryl C C), 1511 (s), 1100 (s); 1H NMR(CDCl3): 9.19 (1H, s, Ar-H), 8.43-8.42 (1H, m, Ar-H), 8.38(1H, d, Ar-H), 5.73 (2H, s, -N-NH2), 2.20 (3H, s, -C-CH3);13C NMR (CDCl3): 151.73 (C N), [144.85, 142.57, 142.48,142.36] (py-C), 8.89 (-CH3); MS/EI (m/z) (I, %) for C6H8N4: 136 [M]+ (100), 107 [C6H7N2]+ (59), 79 [C4H3N2]+ (83), 57[C2H5N2]+ (89), 52 [C2N2]+ (68).

The synthetic route of Acetylpyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kassim, Muhammad Arif; Yassin, Ubaidullah H. M.; Tan, Ai Ling; Usman, Anwar; Hamid, Malai Haniti S. A.; Acta Crystallographica Section C: Structural Chemistry; vol. 74; 4; (2018); p. 424 – 427;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

22047-25-2, name is Acetylpyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Acetylpyrazine

General procedure: Ketone (20 mmol) (2-acetylpyridine, 2-acetylthiazole or 2-acetylpyrazine)was added to a solution of aldehyde (10 mmol) (4-methoxybenzaldehyde,4-methoxy-1-naphthaldehyde or 6-methoxy-2-naphthaldehyde) in EtOH (75 mL). KOH (1.54 g, 27.5 mmol) and NH3(aq)(35 mL) were then added. The solution was stirred at room temp. for 24 h. The solid was collected by filtration and washed with H2O. Recrystallization from ethanol (L1,L4, L7) or toluene (L2, L3, L5, L6, L8,L9) afforded a crystalline solid.

The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Klemens, Tomasz; ?witlicka, Anna; Machura, Barbara; Kula, S?awomir; Krompiec, Stanis?aw; ?aba, Katarzyna; Korzec, Mateusz; Siwy, Mariola; Janeczek, Henryk; Schab-Balcerzak, Ewa; Szalkowski, Marcin; Grzelak, Justyna; Ma?kowski, Sebastian; Dyes and Pigments; vol. 163; (2019); p. 86 – 101;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 22047-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22047-25-2, name is Acetylpyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

[Reference Example 6] 1-(6-Methoxy-3-pyridyl)-5-(2-pyrazinyl)-1H-pyrazole-3-carboxylic acid [Show Image] [Show Image] Lithium bis(trimethylsilyl)amide (a 1.0 M solution in tetrahydrofuran, 11.0 mL) was added to a solution of 1-(2-pyrazinyl)-1-ethanone (1.22 g) in tetrahydrofuran (10 mL) under cooling to -78C, and the resultant mixture was stirred for 55 minutes. Diethyl oxalate (2.05 mL) was added thereto, and the mixture was slowly returned to room temperature, and stirred for 6.5 hours. An aqueous 1 N hydrochloric acid solution (11 mL), water and diethyl ether were added to the reaction solution, and the mixture was partitioned. Then, sodium chloride was added to the aqueous layer to be saturated, and then ethyl acetate was added for extraction. The organic layers were combined, and the solvent was evaporated under reduced pressure, to obtain a crude product of 4-(2-pyrazinyl)-2, 4-dioxobutanoic acid ethyl ester (1.83 g, 82%) as a solid. To a suspension of this crude product (1.58 g) in ethanol (20 mL), a solution formed from a suspension of 5-hydrazino-2-methoxypyridine hydrochloride (1.50 g) of Reference Example 1 in ethanol (80 mL) conditioned with triethylamine (1.9 mL), was added, and the mixture was heated to reflux for 19 hours. Acetic acid (5 mL) was further added to the reaction solution, and the mixture was heated to reflux for 1.5 days. After air cooling, ethyl acetate and a saturated aqueous solution of sodium hydrogen carbonate were added to the reaction solution, and the mixture was partitioned. The organic layer was dried over anhydrous sodium sulfate. After separation by filtration, a residue obtained by evaporating the solvent under reduced pressure was purified by silica gel column chromatography (ethyl acetate-hexane), to obtain 1-(6-methoxy-3-pyridyl)-5-(2-pyrazinyl)-1H-pyrazole-3-carboxylic acid ethyl ester (1.05 g, 45%) as a solid. To a solution of this obtained 1H-pyrazole-3-carboxylic acid ethyl ester product (1.05 g) in ethanol (30 mL), an aqueous 1 N sodium hydroxide solution (10.0 mL) was added, and the mixture was stirred for 16 hours at room temperature. An aqueous 1 N hydrochloric acid solution (15 mL), water and ethyl acetate were added to the reaction solution, and the mixture was partitioned. The organic layer was dried over anhydrous magnesium sulfate. After separation by filtration, the solvent was evaporated under reduced pressure, to obtain a crude product of the title compound (0.883 g, 92%) as a solid. This product was supplied to the subsequent reaction without being purified.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Acetylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1785418; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 22047-25-2, These common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Acetylpyrazine (1.22 g, 0.01 mol) and isoniazid (1.37 g, 0.01 mol) were dissolved in 20 mLabsolute ethanol, and 2 drops formic acid was added as a catalyst. The mixture was refluxedfor 5 h, and the white precipitate formed was isolated by filtration to give HL (2.17 g, 90%). IR (KBr, cm-1): 3559, 3030, 1662, 1632, 1562, 1473, 1437, 1420, 1355, 1294, 1153, 1130, 1070,1026, 997, 825, 788, 723, 624, 523, 483. 1H NMR (500 Hz, CDCl3, delta): 9.21 (s, 1H), 9.00 (s, 1H),8.81 (d, J = 10 Hz, 2H), 8.53 (d, J = 10 Hz, 2H), 7.73 (d, J = 5 Hz, 2H), 2.45 (s, 3H). Anal. Calcd forC12H11N5O: C, 59.92; H, 4.59; N, 29.03. Found: C, 72.21; H, 4.57; N, 29.16.

The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhao, Shan-Shan; Wang, Peng; Wang, Li-Na; Fu, Lin; Han, Xiao-Meng; Qin, Jie; Qian, Shao-Song; Journal of Coordination Chemistry; vol. 70; 5; (2017); p. 885 – 897;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

22047-25-2, name is Acetylpyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 22047-25-2

General procedure: A 100 mL round-bottom flask charged with 2-acetylpyrazine (1.47 g, 2 mmol) was added MeOH (30 mL), KOH pellets (0.675 g,2 mmol) and water (2 mL). The resulting mixture was stirred for10 min and then added corresponding n,n?-dimethoxybenzaldehydes (1.0 g, 1 mmol) and ammonium solution (6 mL) was added slowly stirring at room temperature for 4 h, a white precipitate obtained was filtered, washed with MeOH and diethyl ether. The crude products on recrystallization in a mixture of CHCl3:MeOH (1:1) gave white crystals of desired compounds, 1-4.

The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Golla, Ramesh; Kumar, P. Raghavendra; Suchethan; Foro, Sabine; Nagaraju; Journal of Molecular Structure; vol. 1201; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22047-25-2, name is Acetylpyrazine, A new synthetic method of this compound is introduced below., Formula: C6H6N2O

HL was prepared similarly to the published results [37], whereasempolying 2-acetylpyrazine instead of 2-acetylpyridine. In detail, amixture of 2-acetylpyrazine (1.22 g, 10 mmol) and isonicotinoylhydrazide (1.37 g, 10 mmol) in methanol (30 ml) were refluxing for4 h. The pale-yellow solid was precipitated, then filtered andwashed three times by methanol. Yield: 1.54 g (64%). Elementalanalysis for HL (C12H11N5O) (%): Calcd: C: 59.74; H: 4.60; N: 29.03;Found: C: 59.68; H: 4.47; N: 29.24. 1H NMR (400 MHz, CDCl3) d: 9.14(1H)/8.80 (2H)/8.52 (2H)/7.71e7.72 (2H) for AreH, 2.44 (3H, s,eCH3). FT-IR (cm1): n(NH) 3039, n(C]O) 1670 n(C]N) 1555. 13CNMR (100 MHz, CDCl3): d 165.1, 150.3, 149.8, 146.6, 143.2, 145.7,144.4, 140.9, 122.8, 25.9.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Xu, Jun; Zhou, Tao; Xu, Zhou-Qing; Gu, Xin-Nan; Wu, Wei-Na; Chen, Hong; Wang, Yuan; Jia, Lei; Zhu, Tao-Feng; Chen, Ru-Hua; Journal of Molecular Structure; vol. 1128; (2017); p. 448 – 454;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 22047-25-2, These common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 2-neck round bottom flask attached with calcium chloride guard tube was charged with MeOH (30mL). Then, 2-acetylpyrazine (1.47g, 2mmol) followed by KOH pellets (0.675g, 2mmol) were added and initiated magnetic stirring. To this mixture, distilled water (2mL) was added and continued stirring for 10min. Now, the resulting solution was added the respective n,n?,n?-trimethoxyphenyl benzaldehydes (1.0g, 1mmol) under stirring at room temperature slowly and then 6mL of ammonia solution was added. The reaction mixture was stirred further for 4h. The reaction was monitored by TLC. On completion of reaction by TLC, the reaction mass was filtered and washed with methanol (3×10 mL) and then diethyl ether (3×10 mL) to obtain a white precipitate of respective compounds. Each of the above precipitates was recrystallised in a mixture of CHCl3 and MeOH (1:1) at room temperature for 48h. The resulting colourless single crystals of 1-3 were collected by filtration.

The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ramesh; Sharath Kumar; Raghavendra Kumar; Suchetan; Devaraja; Sabine, Foro; Nagaraju; Journal of Molecular Structure; vol. 1200; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, molecular formula is C6H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Acetylpyrazine

General procedure: General procedure: 8-Hydrazinocaffeine (3) (112 mg;0.5 mmol) and carbonyl compound (1 mmol; 2 eq.) were mixedin ethanol (20 mL, containing 0.2 mL of acetic acid) and heated at 75 omicronC for 3 days. After cooling down, reaction mixture was evaporatedto dryness and solid residue was suspended in diethyl ether(50 mL), filtered off, washed with additional portion of diethylether (3 25 mL) and dried in vacuo at 50 C to obtain the hydrazone.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 22047-25-2, its application will become more common.