Category: 21948-70-9

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21948-70-9 as follows. Product Details of 21948-70-9

General procedure: To a stirred solution of 2-(Methylthio)Pyrazine (0.013 g,0.10 mmol) in 5 mL of methanol, AgPF6 (0.051 g, 0.20 mmol) wasadded. Just after addition a white precipitate was formed and thereaction mixture was stirred for 30 min. The precipitate collectedand dried under vacuum. The white powder was dissolved in acetonitrileand kept for crystallization in dark. After few days colourlessrod shape crystals suitable for single crystal X-ray diffractionwere obtained. Yield: 0.059 g (79%). Anal. Calc. for C5H6N2F6PSAg:C, 15.85; H, 1.60; N, 7.39, Found: C, 15.52; H, 1.54; N, 8.03%. IR(KBr, cm1): 3067 (w), 2996 (w), 2924 (w), 1635 (w), 1507 (m),1468 (m), 1383 (m), 1299 (w), 1137 (s), 1046 (m), 1002 (m), 827(s), 561 (s). 1H NMR (DMSO, dppm): 2.53 (Me), 8.29, 8.47, 8.57(pyrazine ring). 13C NMR (DMSO, dppm): 12.68 (Me), 140.14,143.32, 144.83, 157.37 (pyrazine ring).

According to the analysis of related databases, 21948-70-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Singh, Suryabhan; Raghuvanshi, Abhinav; Mathur, Pradeep; Singh, Amrendra K.; Polyhedron; vol. 169; (2019); p. 8 – 13;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 21948-70-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21948-70-9, name is 2-Methylthiopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Example 41Preparation of Compound 215Step A – Synthesis of 2-BenzylpyrazineTo a solution of 2-methylsulfanyl-pyrazine (1.26 g, 10 mmol) in 15 mL THF was added benzylzinc bromide (0.5M in THF, 40 mL, 20 mmol) followed by Pd(Ph3P)4 (1.16 g, 1 mmol). The resulting reaction was heated to 60 C and allowed to stir at this temperature for 2 hours, after which time the reaction mixture was cooled to room temperature, diluted with ethyl acetate and washed with saturated sodium bicarbonate solution. The organic fraction was dried (sodium sulfate), filtered, and concentrated in vacuo to provide a crude residue which was purified using flash column chromatography (15% ethyl acetate in hexane) to provide 2- benzylpyrazine (0.76 g, 45% yield).

The synthetic route of 2-Methylthiopyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2008/130581; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 21948-70-9, A common heterocyclic compound, 21948-70-9, name is 2-Methylthiopyrazine, molecular formula is C5H6N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The mixture of 2-methylthiopyrazine (120 mg, 0.95 mmol) andMeI (203 mg 1.43 mmol) was stirred in a closed vial at 80 C for 2 h.The precipitated orange powder of [MMTP]I was washed withdiethyl ether (2 Chi 8 mL) and dried under vacuum. Yield: 230 mg(90%). 1H NMR (500.13 MHz, CD3CN): delta = 9.03 (dd, JHH = 5.1, 2.8 Hz,1H, C2-H), 8.73 (s, 1H, C5-H), 8.27 (s, 1H, C6-H), 4.25 (s, 3H,Me-N), 2.69 (s, 3H, Me-S). FT-IR (KBr, cm-1): 380 (vs), 420 (w), 449(s), 528 (m), 710 (s), 746 (s), 831 (s), 874 (s), 887 (s), 955 (s), 982 (s),1003 (m), 1124 (s), 1144 (w), 1173 (m), 1221 (vw), 1240 (s), 1260 (s),1281 (s), 1317 (vs), 1439 (m), 1454 (m), 1472 (m), 1528 (s), 1611 (s),2851 (vs), 2916 (vs), 2988 (s), 3028 (s), 3051 (s), 3100 (s). Anal. Calcdfor C6H9IN2S: , 26.88; , 3.38; N, 10.45. Found: , 26.9; , 3.3; N,10.3.

The synthetic route of 21948-70-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Artem’ev, Alexander V.; Bagryanskaya, Irina Yu; Journal of Molecular Structure; vol. 1173; (2018); p. 743 – 749;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 21948-70-9, name is 2-Methylthiopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 21948-70-9

In this example, N-heterocycles such as thiomethylpyrazine and isoquinoline were reacted with iPr2NBEt3 · Met bases generating the organoborate intermediates which were subsequently reacted in Suzuki type cross-coupling reactions furnishing the corresponding substituted N-heterocycles 6h-j as shown in Scheme 8a and Table 4.Scheme 8aAs shown in Scheme 8a, the substrate is reacted with the base to form a metallic organoborate intermediate. The metallic organoborate intermediate is reacted with the electrophile identified in Table 4 to form the respective products by cross-coupling the metallic organoborate intermediate with the Ar-Br electrophile (0.8 equiv) and ZnCl2 (10 mol%) in the presence of Pd(OAc)2 (3 mol%) and S-Phos (6 mol%) at 50C for 12 hours. All reactions were conducted in THF. The results are shown in Table 4 below. Table 4: Functionalization of N-heterocycles using iPr2NBEt3-derived bases6j : 79

The synthetic route of 2-Methylthiopyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HAAG, Benjamin; WO2012/85169; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 21948-70-9, name is 2-Methylthiopyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21948-70-9, Formula: C5H6N2S

General procedure: In the glovebox, aryl methyl sulfane (0.5 mmol), alkyl thiol (2.0 equiv, 1 .0 mmol),LiHMDS (1 .3 ml, 1.0 M in toluene), and SingaCycle Al (0.4 mol%, 0.4 ml, 0.005 Min toluene) were added into an oven-dried 8 ml vial with a magnetic stirring bar, followed by addition of toluene (0.3 ml). The vial was sealed and removed out of the glovebox and heated to 100 00. After 12 h, the vial was cooled to room temperature. The reaction was diluted with ethyl acetate and washed withsaturated NaOH solution. The aqueous phase was extracted with ethyl acetate 3 times. The collected organic phases were dried over anhydrous Na2504. The solvent was removed under reduced pressure and the residue was purified by flash column chromatography to give the desired product.

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These common heterocyclic compound, 21948-70-9, name is 2-Methylthiopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-Methylthiopyrazine

General procedure: Under the N2 atmosphere,2x (0.5 mmol) was added to the reaction tube in turn.3b (0.75mmol) and dissolved in 1.0M in advanceThe mixture obtained from KHMDS (0.75 mmol) of THF was heated to 100 C, and the reaction was stirred for about 16 hours until the conversion of the starting material was completed, and the temperature was lowered to room temperature.Diluted with THF (3 ml) to the reaction mixture.Filter through silica gel or diatomaceous earth, wash with THF,The crude product was concentrated in vacuo and subjected to silica gel column chromatography to give the corresponding product 1xb.As shown in the following equation, where, lists the yield of 1xb isolated using different 2x as raw materials.For example, when using 2f?,The yield of the product 1f’b was 88%.

The synthetic route of 2-Methylthiopyrazine has been constantly updated, and we look forward to future research findings.

Electric Literature of 21948-70-9, A common heterocyclic compound, 21948-70-9, name is 2-Methylthiopyrazine, molecular formula is C5H6N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 2-(Methylthio)Pyrazine (0.013 g,0.10 mmol) in 5 mL of methanol, AgPF6 (0.051 g, 0.20 mmol) was added. Just after addition a white precipitate was formed and the reaction mixture was stirred for 30 min. The precipitate collectedand dried under vacuum. The white powder was dissolved in acetonitrileand kept for crystallization in dark. After few days colourlessrod shape crystals suitable for single crystal X-ray diffractionwere obtained. Yield: 0.059 g (79%). Anal. Calc. for C5H6N2F6PSAg:C, 15.85; H, 1.60; N, 7.39, Found: C, 15.52; H, 1.54; N, 8.03%. IR(KBr, cm1): 3067 (w), 2996 (w), 2924 (w), 1635 (w), 1507 (m),1468 (m), 1383 (m), 1299 (w), 1137 (s), 1046 (m), 1002 (m), 827(s), 561 (s). 1H NMR (DMSO, dppm): 2.53 (Me), 8.29, 8.47, 8.57(pyrazine ring). 13C NMR (DMSO, dppm): 12.68 (Me), 140.14,143.32, 144.83, 157.37 (pyrazine ring).

The synthetic route of 21948-70-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Singh, Suryabhan; Raghuvanshi, Abhinav; Mathur, Pradeep; Singh, Amrendra K.; Polyhedron; vol. 169; (2019); p. 8 – 13;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 21948-70-9, name is 2-Methylthiopyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21948-70-9, Product Details of 21948-70-9

General procedure: A magnetically stirred solution of xanthate (2.0 equiv) and pyrazine (1.0 equiv) in 1, 2-dichloroethane (1.0mmol/mL according to the xanthate) was refluxed for 15min under a flow of nitrogen. Then dilauroyl peroxide (DLP) was added portionwise (20mol % according to the xanthate) every hour until total consumption of one substrate. The reaction mixture was then cooled to room temperature and the solvent was evaporated under reduced pressure. Unless otherwise specified, the crude product was purified by flash chromatography on silica gel.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Huang, Qi; Qin, Ling; Zard, Samir Z.; Tetrahedron; vol. 74; 40; (2018); p. 5804 – 5817;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 21948-70-9, These common heterocyclic compound, 21948-70-9, name is 2-Methylthiopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of AgClO4 (137mg, 0.67mmol) in MeCN (1mL), 2-methylthiopyrazine (84mg, 0.67mmol) was added and the mixture was stirred at ambient temperature for 5min. The resulting solution was filtered and Et2O (6mL) was then layered on a filtrate. The mixture was left overnight at 5C. The precipitated X-ray quality crystals were collected and dried in air. Yield: 210mg (95%). FT-IR (KBr, cm-1): 413 (w), 432 (vw), 494 (vw), 625 (s), 696 (vw), 741 (w), 762 (w), 843 (m), 974 (m), 1084 (vs), 1144 (s), 1292 (w), 1393 (w), 1441 (w), 1466 (w), 1508 (w). Anal. Calcd: C10H12Ag2Cl2N4O8S2 (663.76): C, 18.0; H, 1.8; N, 8.4; S, 9.6 Found: C, 18.2; H, 1.9; N, 8.5; S, 9.8.

Statistics shows that 2-Methylthiopyrazine is playing an increasingly important role. we look forward to future research findings about 21948-70-9.

Reference:
Article; Rogovoy, Maxim I.; Berezin, Alexey S.; Kozlova, Yuliya N.; Samsonenko, Denis G.; Artem’ev, Alexander V.; Inorganic Chemistry Communications; vol. 108; (2019);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

A common compound: 21948-70-9, name is 2-Methylthiopyrazine, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 21948-70-9

To a mixture of 2-(methylthio)pyrazine (59 mg, 0.46 mmol) and CuI (44.5 mg,0.23 mmol), MeCN (5 mL) was added and the suspension was stirred at ambient temperature for 1 h. The precipitated redorangepowder was centrifuged and re-crystallized from acetonitrile to give 36 mg (35%) of 1. FT-IR (KBr, cm-1): 376 (w),397 (w), 413 (w), 434 (w), 484 (m), 633 (w), 648 (w), 723 (m), 762 (vs), 964 (m), 1007 (m), 1053 (m), 1094 (m), 1130 (m),1159 (s), 1263 (m), 1375 (m), 1420 (s), 1456 (s), 1560 (m), 1584 (s), 2922 (w), 2963 (w), 2982 (w), 3061 (w), 3098 (w).Anal. Calcd (%) for C20H24Cu2I2N8S4: 27.1, 2.7, N 12.6, S 14.5. Found: 27.0, 2.9, N 12.5, S 14.7.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 21948-70-9, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Artem?ev; Beresin; Bagryanskaya, I. Yu.; Journal of Structural Chemistry; vol. 60; 6; (2019); p. 967 – 971; Zh. Strukt. Kim.; vol. 60; 6; (2019); p. 1008 – 1012,5;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem