Category: 2150-55-2

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Huai, Lihua; Chen, Ning researched the compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ).Name: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.They published the article 《Effect of dissolved oxygen on production of L-cysteine synthetase by Pseudomonas sp. TS1138》 about this compound( cas:2150-55-2 ) in Shipin Kexue (Beijing, China). Keywords: dissolved oxygen cysteine synthetase Pseudomonas fermentation. We’ll tell you more about this compound (cas:2150-55-2).

Pseudomonas sp. TS1138 has potential to produce L-cysteine synthetase through asym. hydrolysis of DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC). The effect of dissolved oxygen level on the production of L-cysteine synthetase was investigated in shake flasks or 7 L bioreactor. The results indicated that the cell growth and the production of L-cysteine synthetase were inhibited at low dissolved oxygen level. Although cell growth was improved at the high dissolved oxygen level, the inhibition against production of L-cysteine synthetase was still observed in shake flasks. In 7 L bioreactor, dissolved oxygen concentration controlled at more than 30% was helpful for improving the cell growth and the production of L-cysteine synthetase through regulating agitation rate and air flow rate during the middle and late stage.

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Pyrazine – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Seizures and selective CA-1 hippocampal lesions induced by an excitotoxic cyanide metabolite, 2-iminothiazolidine-4-carboxylic acid, published in 1995, which mentions a compound: 2150-55-2, Name is 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, Molecular C4H6N2O2S, HPLC of Formula: 2150-55-2.

Excitatory amino acid (EAA)-like and excitotoxic properties of the secondary metabolite of cyanide, 2-iminothiazolidine-4-carboxylic acid (2-ICA), were evaluated because of its possible role in cyanide-induced neurotoxicity. Intracerebroventricular (i.c.v.) injections of 2-ICA in mice produced wild-running seizures that were qual. and quant. similar to seizures observed with glutamate. 2-ICA, kainate, and proline seizures were prevented by both the NMDA and non-NMDA antagonists, MK-801 and CNQX, resp. In contrast, NMDA-induced seizures were prevented by MK-801, but not CNQX. When infused i.c.v. in rats over a 7-day period, 2-ICA produced extensive and selective loss of CA-1 pyramidal neurons of the hippocampus. In hippocampal slices preloaded with D-[3H]aspartate, 2-ICA superfusion did not evoke release nor significantly augment potassium-stimulated release of the radiolabeled transmitter. These findings indicate 2-ICA has excitotoxic properties and its role in cyanide neurotoxicity deserves further study.

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Pyrazine – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Youn, Sung Hun; Park, Hae Woong; Choe, Deokyeong; Shin, Chul Soo researched the compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ).Reference of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.They published the article 《Preparation of eutectic substrate mixtures for enzymatic conversion of ATC to L-cysteine at high concentration levels》 about this compound( cas:2150-55-2 ) in Bioprocess and Biosystems Engineering. Keywords: enzymic conversion eutectic mixture cysteine production. We’ll tell you more about this compound (cas:2150-55-2).

High concentration eutectic substrate solutions for the enzymic production of L-cysteine were prepared Eutectic melting of binary mixtures consisting of D,L-2-amino-Δ2-thiazoline-4-carboxylic acid (ATC) as a substrate and malonic acid occurred at 39 °C with an ATC mole fraction of 0.5. Formation of eutectic mixtures was confirmed using SEM, SEM-EDS, and XPS surface analyses. Sorbitol, MnSO4, and NaOH were used as supplements for the enzymic reactions. Strategies for sequential addition of five compounds, including a binary ATC mixture and supplements, during preparation of eutectic substrate solutions were established. Eutectic substrate solutions were stable for 24 h. After 6 h of enzymic reactions, a 550 mM L-cysteine yield was obtained from a 670 mM eutectic ATC solution

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Pyrazine – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2150-55-2, is researched, Molecular C4H6N2O2S, about Theoretical and experimental approach to hydrophilic interaction dispersive solid-phase extraction of 2-aminothiazoline-4-carboxylic acid from human post-mortem blood, the main research direction is hydrophilic interaction dispersive solid phase extraction; 2-Aminothiazoline-4-carboxylic acid; Dispersive solid phase extraction; Human post-mortem blood; Mixed-mode cation exchange sorbent; Molecular modeling; Molecularly imprinted polymer.Related Products of 2150-55-2.

The authors proposed an innovative hydrophilic interaction dispersive solid-phase extraction (HI-d-SPE) protocol suitable for the isolation of the potential cyanide intoxication marker, 2-aminothiazoline-4-carboxylic acid (ATCA), from such complicated matrix as post-mortem blood. To create an optimal HI-d-SPE protocol, two sorbents were used: a molecularly imprinted polymer (MIP) and com. available Oasis-MCX. The latter sorbent was identified as more recovery-efficient with higher clean-up abilities in a carefully optimized process. Computational anal. was employed to provide insight into the adsorption mechanism of the two selected sorbents. The theor. results were in agreement with the experiment regarding the efficiency of the sorbent. HI-d-SPE was successfully applied to the anal. of ATCA in 20 post-mortem blood samples using LC-MS/MS. The anal. performance of the method was finally compared to prior existing methods, in turn revealing its superiority.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Agricultural and Biological Chemistry called Asymmetric synthesis of S-carboxymethyl-L-cysteine by a chemicoenzymic method, Author is Yokozeki, Kenzo; Eguchi, Chikahiko; Kamimura, Akira; Kubota, Koji, which mentions a compound: 2150-55-2, SMILESS is O=C(C1N=C(N)SC1)O, Molecular C4H6N2O2S, Reference of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.

A chemienzymic method is developed for production of S-carboxymethyl-L-cysteine (I) from DL-2-aminothiazoline-4-carboxylic acid (II) in the presence of ClCH2CO2H using a hydrolyzing system. The carboxymethylation of L-cysteine with ClCH2CO2H to I proceeded effectively at 26° and pH ≥8.0, the yield reaching nearly 100%. The carboxymethylation of II with ClCH2CO2H was not observed Next, the production of I from II in the presence of ClCH2CO2H was examined using rinsed cells of Pseudomonas desmolytica AJ-11898. About 10 g I/L was produced from 18 g II/L in 8 h, the molar yield being 45%. This finding shows that the aminothiazolinecarboxylate racemase in P. desmolytica AJ-11898 may be inhibited by the ClCH2CO2H added to the reaction mixture In fact, the II remaining in the reaction mixture was in the D-form. Moreover, the yield of L-cysteine from DL-II in the absence of ClCH2CO2H was ∼50% when cells of AJ-11898 pretreated with SH reagents were used as the enzyme source.

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Pyrazine – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2150-55-2, is researched, SMILESS is O=C(C1N=C(N)SC1)O, Molecular C4H6N2O2SJournal, Article, Bioscience, Biotechnology, and Biochemistry called N-carbamoyl-L-cysteine as an intermediate in the bioconversion from D,L-2-amino-Δ2-thiazoline-4-carboxylic acid to L-cysteine by Pseudomonas sp. ON-4a, Author is Tamura, Yoshiharu; Nishino, Mizuka; Ohmachi, Tetsuo; Asada, Yoshihiro, the main research direction is Pseudomonas carbamoylcysteine; 2-amino-Δ 2-thiazoline-4-carboxylic acid (ATC); L-cysteine; N-carbamoyl-L-cysteine (L-NCC); Pseudomonas species; bioconversion.Quality Control of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.

The authors investigated the conversion of D,L-2-amino-Δ2-thiazoline-4-carboxylic (D,L-ATC) to L-cysteine with Pseudomonas sp. ON-4a, an ATC-assimilating bacterium. Cysteine and N-carbamoylcysteine (NCC), but not S-carbamoylcysteine (SCC), were produced from D,L-ATC by a cell-free extract from the strain. These products were isolated from the reaction mixture and then identified as the L-form. Similar results were obtained with P. putida AJ3865 and unidentified strain TG-3, an ATC-assimilating bacteria. It became clear that L-NCC is an intermediate in the conversion of D,L-ATC to L-cysteine in these Pseudomonas strains. Furthermore, it was suggested that these bacteria have L-ATC hydrolase and L-NCC amidohydrolase.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid(SMILESS: O=C(C1N=C(N)SC1)O,cas:2150-55-2) is researched.Product Details of 2150-55-2. The article 《Development of enzymic process producing L-cysteine. 2. Improvement of Pseudomonas desmolytica for the enzymatic production of L-cystine》 in relation to this compound, is published in Nippon Nogei Kagaku Kaishi. Let’s take a look at the latest research on this compound (cas:2150-55-2).

In a process to produce L-cystine from DL-2-thiazolin-4-carboxylic acid (ATC) using the enzymic activity of Pseudomonas strains, we proposed the oxidation-reduction potential (ORP) as a criterion to optimize the process in the previous paper. To scale up this process, it was required to reduce the generation of hydrogen sulfide (H2S). A mutant strain of P. desmolytica AJ-11071 which has a higher yield of L-cystine from ATC and lower activity of L-cysteine hydrolysis to generate H2S gas was developed in this experiment An improved strain Number4 in a 65 kL reactor produced 90 g /L of L-cystine from 110 g/L ATC at the molar yield of 93% in 36 h.

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Application In Synthesis of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Genes from Pseudomonas sp. strain BS involved in the conversion of L-2-amino-Δ2-thiazolin-4-carbonic acid to L-cysteine. Author is Shiba, Toshikazu; Takeda, Kohji; Yajima, Misako; Tadano, Makoto.

DL-2-Amino-Δ2-thiazoline-4-carbonic acid (DL-ATC) is a substrate for cysteine synthesis in some bacteria, and this bioconversion has been utilized for cysteine production in industry. We cloned a DNA fragment containing the genes involved in the conversion of L-ATC to L-cysteine from Pseudomonas sp. strain BS. The introduction of this DNA fragment into Escherichia coli cells enabled them to convert L-ATC to cysteine via N-carbamoyl-L-cysteine (L-NCC) as an intermediate. The smallest recombinant plasmid, designated pTK10, contained a 2.6-kb insert DNA fragment that has L-cysteine synthetic activity. The nucleotide sequence of the insert DNA revealed that two open reading frames (ORFs) encoding proteins with mol. masses of 19.5 and 44.7 kDa were involved in the L-cysteine synthesis from DL-ATC. These ORFs were designated atcB and atcC, resp., and their gene products were identified by overproduction of proteins encoded in each ORF and by the maxicell method. The functions of these gene products were examined using extracts of E. coli cells carrying deletion derivatives of pTK10. The results indicate that atcB and atcC are involved in the conversion of L-ATC to L-NCC and the conversion of L-NCC to cysteine, resp. AtcB was first identified as a gene encoding an enzyme that catalyzes thiazoline ring opening. AtcC is highly homologous with L-N-carbamoylases. Since both enzymes can only catalyze the L-specific conversion from L-ATC to L-NCC or L-NCC to L-cysteine, it is thought that atcB and atcC encode L-ATC hydrolase and N-carbamoyl-L-cysteine amidohydrolase, resp.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Weuffen, W.; Jess, G.; Juelich, W. D.; Bernhardt, D. researched the compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ).Product Details of 2150-55-2.They published the article 《Studies on the relation between 2-iminothiazolidine-4-carboxylic acid and the thiocyanate metabolism in the guinea pig》 about this compound( cas:2150-55-2 ) in Pharmazie. Keywords: iminothiazolidine carboxylate metabolism; thiocyanate iminothiazolidine carboxylate metabolite. We’ll tell you more about this compound (cas:2150-55-2).

In vitro and in vivo experiments have been carried out to elucidate the metabolism of 2-iminothiazolidine-4-carboxylic acid (I) [2150-55-2]. By using I-35S, the formation. of 35SCN as well as of 35S-containing I metabolites could be excluded. As compared to the findings from control animals, the serum SCN levels determined in guinea pigs after oral administration of I were unchanged.

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COA of Formula: C4H6N2O2S. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about 2-Iminothiazolidine-4-carboxylic acid produces hippocampal CA1 lesions independent of seizure excitation and glutamate receptor activation. Author is Bitner, R. S.; Yim, G. K. W.; Isom, G. E..

In this study, the ability of either 2-iminothiazolidine-4-carboxylic acid (2-ICA), glutamate, proline or NMDA (N-methyl-D-aspartate) injected i.c.v. to produce hippocampal lesions sensitive to glutamate antagonists was compared in mice. Hippocampal CA1 damage was observed 5-days following either a seizure (3.2 μmol) or subseizure (1.0 μmol) dose of 2-ICA. Glutamate (3.2 μmol) or proline (10 μmol) also produced hippocampal damage; glutamate damage was primarily to the CA1 subfield, whereas proline damaged neurons throughout the entire hippocampal formation. NMDA (3.2 nmol) caused seizure activity in all animals with a 50% lethality. No hippocampal damage was observed in surviving mice. Neither MK-801 (dizocilpine maleate) nor CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) pretreatment prevented hippocampal lesions produced by 2-ICA. In contrast, MK-801 significantly reduced the frequency of mice displaying glutamate hippocampal lesions, but failed to block seizures produced by glutamate. MK-801 also protected neurons in the CA2-3 zone and the dentate gyrus, but not in the CA1 region of proline-injected mice. Finally, pretreatment with the mixed metabotropic glutamate receptor (mGluR)1/mGluR2 antagonist-agonist (S)-4-carboxy-3-hydroxyphenylglycine (CHPG) prevented hippocampal damage produced by the mGluR 1 agonist (RS)-3,5-dihydroxyphenylglycine (DHPG), but did not protect against 2-ICA hippocampal lesions. These results show that 2-ICA hippocampal CA1 damage is not mediated through ionotropic or metabotropic glutamate receptors. 2-ICA hippocampal damage may represent a neurotoxicity that is distinct from excitotoxic-mediated cell death.

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Pyrazine – Wikipedia,
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