Category: 2150-55-2

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Cysteine, the main research direction is review cysteine production enzyme.Application of 2150-55-2.

A review with 21 references on the microbial conversion of DL-2-amino-Δ2-thiazoline-4-carboxylic acid  [2150-55-2] to L-cysteine  [52-90-4] and cystine  [56-89-3]; the enzymic synthesis of L-cysteine from β-chloro-L-alanine  [2731-73-9] and Na2S by pyridoxal phosphate-dependent enzymes; and the synthesis of D-cysteine  [921-01-7] by β-chloro-D-alanine dehydrochlorinase  [78990-65-5].

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Enzymatic production of L-cysteine from DL-2-amino-Δ2-thiazoline-4-carboxylic acid by Pseudomonas thiazolinophilum: optimal conditions for the enzyme formation and enzymatic reaction.Quality Control of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.

Cultivation of P. thiazolinophilum AJ 3854 for the production of the enzyme which could form L-cysteine [52-90-4] from DL-2-amino-Δ2-thiazoline-4-carboxylic acid (I) [2150-55-2] and the reaction conditions of this enzyme were investigated. This enzyme was inducible, intracellular, and growth-associated A marked inactivation of enzyme was observed, especially in the growing phase, but could be prevented by 1∼10 mM Mn2+ or by I as inducer at the mid-logarithmic phase. Enzymic degradation of L-cysteine (or L-cystine [56-89-3]) formed from I could be prevented by the addition of hydroxylamine or semicarbazide. Thus, L-cysteine and L-cystine were quant. produced from I. Optimal pH and temperature of enzymic reaction were 8.2 and 42° (2 h), resp. A sigmoidal reaction curve was observed when intact cells were used as enzyme source, but sonic treatment of cells made the curve linear.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about LC-MS/MS method development and validation for quantitative analyses of 2-aminothiazoline-4-carboxylic acid – a new cyanide exposure marker in post mortem blood.HPLC of Formula: 2150-55-2.

2-Aminothiazoline-4-carboxylic acid (ATCA) is a hydrogen cyanide metabolite that has been found to be a reliable biomarker of cyanide poisoning, because of its long-term stability in biol. material. There are several methods of ATCA determination; however, they are restricted to extraction on mixed mode cation exchange sorbents. To date, there has been no reliable method of ATCA determination in whole blood, the most frequently used material in forensic anal. This novel method for ATCA determination in post mortem specimen includes protein precipitation, and derivatization of interfering compounds and their later extraction with Et acetate. ATCA was quant. analyzed via HPLC-tandem mass spectrometry with pos. electrospray ionization detection using a hydrophilic interaction liquid chromatog. column. The method satisfied all validation criteria and was tested on the real samples with satisfactory results. Therefore, this anal. approach has been proven to be a tool for measuring endogenous levels of ATCA in post mortem specimens. To conclude, a novel, accurate and sensitive method of ATCA determination in post mortem blood was developed. The establishment of the method provides new possibilities in the field of forensic science.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of C4H6N2O2S. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Fed-batch fermentation kinetics of L-cysteine producing Pseudomonas strain TS1138. Author is Huai, Lihua; Zhou, Changping; Chen, Ning; Yang, Wenbo; Bai, Gang.

L-cysteine was produced by means of microbial transformation of DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC) in the presence of L-cysteine synthesizing enzyme from Pseudomonas sp. TS1138. Based on the exptl. data of fed-batch fermentation in 5 L fermentation reactor, the kinetic model of cell growth, enzyme production and substrate consumption were constructed. Three kinetic models were in good agreement with the exptl. results through proper anal. by software MATALAB. The kinetic models appeared to provide a reasonable description for each parameter in the fermentation

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Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Application of 2-Aminothiazoline-4-carboxylic Acid as a Forensic Marker of Cyanide Exposure, the main research direction is forensic marker cyanide exposure aminothiazoline 4 carboxylate.SDS of cas: 2150-55-2.

Cyanides are infamous for their highly poisonous properties. Accidental cyanide poisoning occurs frequently, but occasionally, intentional poisonings also occur. Inhalation of fumes generated by fire may also cause cyanide poisoning. There are many limitations in direct anal. of cyanide. 2-Aminothiazoline-4-carboxylic acid (ATCA), a cyanide metabolite, seems to be the only surrogate that is being used in the detection of cyanide because of its stability and its cyanide-dependent quality in biol. matrix. Unfortunately, the toxicokinetic study on diverse animal models suggests significant interspecies differences; therefore, the attempt to extrapolate animal models to human model is unsuccessful. The aim of the present study was to evaluate the use of ATCA as a forensic marker of cyanide exposure. For this purpose, postmortem materials (blood and organs) from fire victims and cyanide-poisoned persons were collected. The distribution of ATCA in organs and its thermal stability were evaluated. The variability of cyanides in purified sample and in the context of their long-term and higher temperature stability was established. The presence of ATCA was detected by using LC-MS/MS method and that of cyanide was detected spectrofluorimetrically. This is the first report on the determination of ATCA distribution in tissues of fire victims and cyanide-poisoned persons. It was found that blood and heart had the highest ATCA concentrations ATCA was observed to be thermally stable even at 90°. Even though the cyanide concentration was not elevated in purified samples, it was unstable during long-term storage and at higher temperature, as expected. The relationship between ATCA and cyanides was also observed Higher ATCA concentrations were related to increased levels of cyanide in blood and organs (less prominent). ATCA seems to be a reliable forensic marker of exposure to LDs of cyanide.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid(SMILESS: O=C(C1N=C(N)SC1)O,cas:2150-55-2) is researched.Synthetic Route of C8H8N4. The article 《Study on fermentation conditions and culture medium of enzymatic synthesis of L-cysteine》 in relation to this compound, is published in Xiandai Huagong. Let’s take a look at the latest research on this compound (cas:2150-55-2).

L-cysteine synthesizing enzyme could be produced in Pseudomonas sp.TS1138, induced by DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC). Optimum conditions suitable for enzyme production in Pseudomonas sp. TS1138 were studied and the results showed that enzymes activity in Pseudomonas sp. TS1138 was highest when the cultivate conditions were as follows: mass concentration of DL-ATC was 5 g/L, glucose and urea were carbon and nitrogen source resp., fermentation temperature was 27-29°C, liquid volume of culture medium was 40 mL in a 500 mL shaking flask. The highest enzymes activity could reach 1,780 U/mL in a 7 L fermentor under the optimum conditions.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recommanded Product: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Study on L-cystine conversion technology by Pseudomonas putida TS1138. Author is Liu, Chunqin; Yu, Yangsheng; Bai, Gang; Yang, Wenbo; Chen, Ning; Huai, Lihua.

A technol. of L-cystine production was studied in this paper, which included microbial enzymic conversion of DL-2-amino-Δ2-thiazoline-4- carboxylic acid (DL-ATC) to L-cysteine, subsequent oxidization of L-cysteine to L-cystine and its purification The cells of Pseudomonas putida TS1138 could be repetitively used as the enzyme sources to convert the substrate DL-ATC to L-cysteine. After being oxidized by 2% dimethy-sulfoxide (DMSO), L-cystine could be harvested and further purified by the pos. ion-exchange resin 001*7. High Performance Liquid Chromatog. (HPLC) identified the purified L-cystine as having a total recovery of 78.55% and purity of 99.12%. This study demonstrated an efficient and convenient method for L- cystine production, which overcame the instability of enzymes, troublesome procedures and high cost of enzyme immobilization as contrasted to the traditional method. All in all, it provides a new approach for industrial production of L- cystine as well as L-cysteine.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Study on L-cystine conversion technology by Pseudomonas putida TS1138, published in 2008-01-20, which mentions a compound: 2150-55-2, mainly applied to Pseudomonas cystine cysteine, COA of Formula: C4H6N2O2S.

A technol. of L-cystine production was studied in this paper, which included microbial enzymic conversion of DL-2-amino-Δ2-thiazoline-4- carboxylic acid (DL-ATC) to L-cysteine, subsequent oxidization of L-cysteine to L-cystine and its purification The cells of Pseudomonas putida TS1138 could be repetitively used as the enzyme sources to convert the substrate DL-ATC to L-cysteine. After being oxidized by 2% dimethy-sulfoxide (DMSO), L-cystine could be harvested and further purified by the pos. ion-exchange resin 001*7. High Performance Liquid Chromatog. (HPLC) identified the purified L-cystine as having a total recovery of 78.55% and purity of 99.12%. This study demonstrated an efficient and convenient method for L- cystine production, which overcame the instability of enzymes, troublesome procedures and high cost of enzyme immobilization as contrasted to the traditional method. All in all, it provides a new approach for industrial production of L- cystine as well as L-cysteine.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Formula: C4H6N2O2S. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Progress on enzymatic synthesis of L-cysteine from DL-ATC by Pseudomonas sp.. Author is Wu, Min; Chen, Wei-qing; Wang, Pu; He, Jun-yao.

A review. The microbial transformation method for L-cysteine production shows evident advantages, because of its short cycle time, low cost, high region and stereoselectivity, easy control of reaction condition, and environment-friendly. Recently, studies on the bioconversion of DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC) to L-cysteine by intracellular enzymes were reported. The research progresses on L-cysteine production by microbial bioconversion, especially Pseudomonas sp., or its crude enzyme extract are summarized. The applications of immobilization technol. in the biotransformation of DL-ATC to L-cysteine are introduced. The genetically engineered bacteria and the study progresses of L-cysteine desulfhydrase were also discussed.

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Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Formation of 2-iminothiazolidine-4-carboxylic acid in the cyanobromination of lanthionine》. Authors are van Rensburg, N. J. J..The article about the compound:2-Amino-4,5-dihydrothiazole-4-carboxylic acidcas:2150-55-2,SMILESS:O=C(C1N=C(N)SC1)O).Related Products of 2150-55-2. Through the article, more information about this compound (cas:2150-55-2) is conveyed.

A 5 ml. solution of lanthionine in 0.1N HCl was added to 5 ml. 5% aqueous NaCN and the mixture treated with 1 ml. NCBr solution (prepared by adding 5% aqueous NaCN to a saturated solution of Br till the solution was just colorless). After 3 consecutive boilings for 30 secs. and cooling for 3 min., the thiol content estimation was interfered with by incomplete removal of NCBr. The reaction mixture was, therefore, boiled for 10 min., but the quantity of thiol formed was not consistent and reproducibility of the results was very poor. Paper chromatography of the products in sec-BuOH-HCOOH-H2O (75:15:10) system showed the presence of 2-iminothiazolidine-4-carboxylic acid (I). In these experiments, HCl was converted to HCN, which was expelled on boiling and probably the high pH led to the formation of the acid.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem