Category: 2150-55-2

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2150-55-2, is researched, Molecular C4H6N2O2S, about One-pot synthesis of DL-2-amino-2-thiazoline-4-carboxylic acid, the main research direction is chloropropionic acid reaction thiourea; aminothiazoline carboxylic acid preparation.Quality Control of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.

DL-2-Amino-2-thiazoline-4-carboxylic acid was prepared in one-pot reaction from 2,3-dichloropropionic acid. Not only the procedure was simplified, but also the yield was increased from less than 63% recorded to 93%.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Computed Properties of C4H6N2O2S. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Quantification of 2-aminothiazoline-4-carboxylic acid as a reliable marker of cyanide exposure using chemical derivatization followed by liquid chromatography-tandem mass spectrometry.

In this research, we have developed a novel and simple liquid chromatog. coupled with electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) method for quantification of 2-aminothiazoline-4-carboxylic acid (ATCA), which is produced by the direct reaction of cyanide (CN) with endogenous cystine. In forensic science, detection of CN is important because CN is a poison that is often used for murder or suicide, in addition to being produced by the thermal decomposition of natural or synthetic materials. However, because CN disappears rapidly from body tissue, ATCA is thought to be a more reliable indicator of CN exposure. For the method reported herein, human blood samples (20μL) were subjected to protein precipitation followed by derivatization with 4-bromoethyl-7-methoxycoumarin. Blood spiked with ATCA at concentrations ranging from 50 to 1500 ng/mL was used to prepare a calibration curve (lower limit of quantification; 50 ng/mL, lower limit of detection; 25 ng/mL). Our method uses chem. derivatization, so unlike previously reported methods, it does not require tedious pretreatment procedures, hydrophilic interaction liquid chromatog. columns, or specialized equipment. In addition, our method allows for repeatable and accurate quantification of ATCA, with intra- and inter-assay coefficients of variation of below 5.0% and below 6.0%, resp. We used the method to analyze ATCA in postmortem human blood samples, including samples from people who had intentionally ingested CN or were fire victims. Blood ATCA concentrations were higher among people who had ingested CN or were fire victims than among people in a control group (P < 0.0001). The data reported herein demonstrate that our LC/ESI-MS/MS method can be used to detect and quantify ATCA in postmortem blood samples and that CN exposure strongly affects ATCA concentration, providing a useful tool for detection of CN poisoning. Although many compounds look similar to this compound(2150-55-2)Computed Properties of C4H6N2O2S, numerous studies have shown that this compound(SMILES:O=C(C1N=C(N)SC1)O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid(SMILESS: O=C(C1N=C(N)SC1)O,cas:2150-55-2) is researched.Quality Control of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid. The article 《Continuous L-cysteine production using immobilized cell reactors and product extractors》 in relation to this compound, is published in Process Biochemistry (Oxford). Let’s take a look at the latest research on this compound (cas:2150-55-2).

Methods to improve the stability of L-cysteine-producing enzymes from Pseudomonas sp. M-38, both as whole cells and as immobilized cells, were investigated for the production of L-cysteine from DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC). Among the 3 L-cysteine-producing enzymes, only L-ATC hydrolase was unstable. However, the stability of L-ATC hydrolase was significantly enhanced by the addition of 20% sorbitol. In continuous L-cysteine production, >60% of the initial activity of L-ATC hydrolase remained after 1000 h at 37° with 40% sorbitol and at 30° with 20% sorbitol. A system involving a cascade of processes using 2 packed-bed reactors with immobilized cells and 2 L-cysteine extractors with the ion-exchange resin Dowex 50W was developed to reduce product inhibition and unreacted substrate. The overall productivity of the system was 43% higher than for 2 reactors without an ion-exchange extractor.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

SDS of cas: 2150-55-2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Molecularly imprinted polymer stir bar sorption extraction and electrospray ionization tandem mass spectrometry for determination of 2-aminothiazoline-4-carboxylic acid as a marker for cyanide exposure in forensic urine analysis. Author is Jackson, Randy; Petrikovics, Ilona; Lai, Edward P. C.; Yu, Jorn C. C..

In forensic casework, a stable and quantifiable marker is desirable for the determination of cyanide poisoning in biol. fluids. 2-Aminothiazoline-4-carboxylic acid (ATCA) is a chem. stable urinary metabolite of cyanide that has been considered to be a reliable biol. marker for cyanide exposure. However, endogenous ATCA is always present in low quantity originating from either dietary intake of cyanide or from normal metabolism of amino acids. A selective and sensitive anal. method is needed to determine the endogenous level of ATCA in order to identify cyanide poisoning. The objective of this research was to prepare molecularly imprinted polymers (MIPs) on the surface of a silica stir bar for molecularly imprinted stir bar sorption extraction (MISBSE). Under optimal extraction conditions, the MISBSE could selectively preconc. ATCA from urine samples. The binding capacity of one MISBSE stir bar for ATCA was determined to be 35 ± 3 ng (n = 3). Combining MISBSE with electrospray ionization tandem mass spectrometry (ESI/MS/MS), ATCA was detected without derivatization at the 400 ng/mL concentration level. This new strategy of MISBSE-ESI/MS/MS enhanced the selectivity and sensitivity for the detection of ACTA in urine samples.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Analytical Biochemistry called Analysis of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid in urine by high-performance liquid chromatography, Author is Lundquist, Per; Kagedal, Bertil; Nilsson, Lennart; Rosling, Hans, which mentions a compound: 2150-55-2, SMILESS is O=C(C1N=C(N)SC1)O, Molecular C4H6N2O2S, Product Details of 2150-55-2.

The cyanide metabolite 2-aminothiazoline-4-carboxylic acid (ATC) was converted to N-carbamylcysteine and analyzed by high-performance liquid chromatog. (HPLC) and fluorometric detection. ATC was first separated from interfering substances by passing through the cation exchanger AG 50W-X8. Interfering disulfides were converted to thiols by reduction of the eluate with thiopropyl-Sepharose 6B. The thiols were then adsorbed to the organomercurial adsorbent p-acetoxymercurianiline-Sepharose 4B while ATC was obtained in the effluent. ATC was then converted to N-carbamylcysteine by ring opening at high temperature in an alk. environment. Derivatization of N-carbamylcysteine was with N-(7-dimethylamino-4-methyl-3-coumarinyl)maleimide. The imprecision (CV) of the method was 3.6% and the anal. recovery was quant. The detection limit was 0.3 μM. ATC in urine was stable for at least 3 mo when stored at -196 to +20 °C. The ATC concentration in urine was below the limit of detection in healthy nonsmokers. The utility of the method was demonstrated by the finding of up to 10.5 μM ATC concentrations in urine samples from human subjects in Mozambique living on a high dietary intake of cyanide from the cassava root. In a metabolic study rats were exposed to acetonitrile in the drinking water. After 4 wk very high ATC levels were found in the urine, representative values from two rats being 195 and 525 μM, resp.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences called One-step elimination of L-cysteine desulfhydrase from crude enzyme extracts of Pseudomonas sp. TS1138 using an immunomagnetic affinity matrix improves the enzymatic production of L-cysteine, Author is Yu, Yangsheng; Bai, Gang; Liu, Chunqin; Cao, Yu; Geng, Peng; Yang, Wenbo, which mentions a compound: 2150-55-2, SMILESS is O=C(C1N=C(N)SC1)O, Molecular C4H6N2O2S, Name: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.

In this study, a high efficiency immunomagnetic affinity matrix was developed to eliminate L-cysteine desulfhydrase (CD), which decomposes L-cysteine, in crude enzyme extracts from Pseudomonas sp. TS1138. After cloning and expression in Escherichia coli, recombinant CD was purified to raise polyclonal antibodies from mice. The anti-CD antibody was cross-linked to staphylococcal protein A-magnetic cellulose microspheres (MCMS) with di-Me pimelimidate (DMP). The natural CD was eliminated from the crude enzyme extracts by treatment with the cross-linked antibody-protein A-MCMS, resulting in a high level of L-cysteine production The conversion rate of DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC) to L-cysteine increased significantly from 61.9 to 96.2%. The cross-linked antibody-protein A-MCMS showed its durability after repetitive use, maintaining a constant binding capacity for CD during five cycles. This study may lead to a convenient and cost-efficient method to produce L-cysteine by enzymic conversions.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Determination of 2-iminothiazolidine-4-carboxylic acid》. Authors are Bradham, L. S.; Catsimpoolas, Nicholas; Wood, John L..The article about the compound:2-Amino-4,5-dihydrothiazole-4-carboxylic acidcas:2150-55-2,SMILESS:O=C(C1N=C(N)SC1)O).Application of 2150-55-2. Through the article, more information about this compound (cas:2150-55-2) is conveyed.

Procedures are described for determination of 2-iminothiazolidine-4-carboxylic acid, using diazotized sulfanilic acid or the mercury-diphenylthiocarbazone reaction. The compound should first be separated from interfering substances such as are found in urine. Paper electrophoresis, ion displacement, or chromatography suffice for this purpose.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid(SMILESS: O=C(C1N=C(N)SC1)O,cas:2150-55-2) is researched.Product Details of 118994-89-1. The article 《Plasma persistence of 2-aminothiazoline-4-carboxylic acid in rat system determined by liquid chromatography tandem mass spectrometry》 in relation to this compound, is published in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. Let’s take a look at the latest research on this compound (cas:2150-55-2).

2-Aminothiazoline-4-carboxylic acid (ATCA) was i.v. injected to rats to investigate its blood plasma distribution. ATCA was extracted from plasma samples by solid phase extraction (SPE) and molecularly imprinted polymer stir bar sorption extraction (MIP-SBSE). Detection and quantification of ATCA were achieved by liquid chromatog.-tandem mass spectrometry (LC-MS/MS). It was found that the i.v. injected ATCA concentration quickly decreased to half within 2.5 h in the rat system. However, after 2.5 h, the concentration of ATCA in plasma stayed constant at least 5 folds above the endogenous ATCA level for more then 48 h. This finding can be used for evaluating ATCA’s diagnostic and forensic value as a biomarker for cyanide exposure.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 2150-55-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Metabolic pathways and biotechnological production of L-cysteine. Author is Wada, Masaru; Takagi, Hiroshi.

A review. L-Cysteine is an important amino acid both biol. and com. Although most amino acids are com. produced by fermentation, cysteine is mainly produced by protein hydrolysis. However, synthetic or biotechnol. products have been preferred in the market. Biotechnol. processes for cysteine production, both enzymic and fermentative processes, are discussed. Enzymic process, the asym. hydrolysis of DL-2-amino-Δ2-thiazoline-4-carboxylic acid to L-cysteine, has been developed and industrialized. The L-cysteine biosynthetic pathways of Escherichia coli and Corynebacterium glutamicum, which are used in many amino acid production processes, are also described. These two bacteria have basically same L-cysteine biosynthetic pathways. L-Cysteine-degrading enzymes and L-cysteine-exporting proteins both in E. coli and C. glutamicum are also described. In conclusion, for the effective fermentative production of L-cysteine directly from glucose, the combination of enhancing biosynthetic activity, weakening the degradation pathway, and exploiting the export system seems to be effective.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tianjin Keji Daxue Xuebao called Optimization of fermentation conditions of microbial enzymatic synthesis of L-cysteine, Author is Kou, Guang-hui; Huai, Li-hua; Bai, Gang; Yang, Wen-bo, which mentions a compound: 2150-55-2, SMILESS is O=C(C1N=C(N)SC1)O, Molecular C4H6N2O2S, Formula: C4H6N2O2S.

Pseudomonas sp. TS1138 was used as the test strain to produce L-cysteine, and microbial enzymic synthesis of L-cysteine was studied. In the medium optimization, it was found that glucose and urea were the best carbon and nitrogen source for enzyme production, resp. Effect of DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC) on enzyme production was carried out, and the exptl. result showed that a initial concentration of 5 g/L DL-ATC was found to be optimal for enzyme production Effects of inoculum size, initial pH and liquid volume on enzyme production were investigated. The results indicated that the optimum inoculum size was 10%, and the optimum initial pH was 8.0. The optimum liquid volume was 40 mL culture medium in a 500 mL shaking flask.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem